Test Price
2,800 AED✅ Home Collection Available
HDAC8 Gene Cornelia de Lange Syndrome Type 5 Genetic Test (NGS) in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل جين HDAC8 لمتلازمة كورنيليا دي لانج النوع الخامس في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited laboratory processing.
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy, ensuring sample integrity from your doorstep.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation provided by our expert genetic counsellors.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
الملخص التنفيذي: يقدم هذا الفحص الجيني المتطور تحليل تسلسل الحمض النووي لجين HDAC8 المرتبط بمتلازمة كورنيليا دي لانج النوع الخامس، وفق أعلى معايير دقة التشخيص وخصوصية البيانات المعتمدة من هيئة الصحة بدبي.
Overview
This test utilises Next-Generation Sequencing (NGS) to thoroughly analyse the entire coding region of the HDAC8 gene, detecting pathogenic variants that cause Cornelia de Lange Syndrome type 5 (CdLS5). It provides a definitive molecular diagnosis for patients presenting with characteristic multisystem features, enabling personalised management and family planning.
يستخدم هذا الاختبار تقنية التسلسل الجيني المتقدمة لفحص كامل المنطقة الترميزية لجين HDAC8، مما يسمح بتشخيص دقيق لمتلازمة كورنيليا دي لانج النوع الخامس وتوجيه الرعاية السريرية والاستشارة الوراثية.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision / Method | Single-nucleotide variant & indel detection >99.9% sensitivity; covers all exons with uniform depth | Targeted analysis of limited regions; lower sensitivity for low-level mosaicism |
| Turnaround Time | 3–4 Weeks | 4–5 Weeks (single gene focus) |
| Comprehensive Reporting | Full clinical interpretation with ACMG classification and genetic counselling support | Variant description without integrated clinical guidance |
| DHA Compliance | Fully aligned with Federal Decree-Law No. 41 of 2024 and UAE PDPL | Variable regulatory alignment |
Physician Insight & Safety Protocol
“As a clinical expert, I understand that pursuing genetic testing for a rare condition can be emotionally challenging. Accurate diagnosis requires correlation with clinical findings, and this test identifies variants in the HDAC8 gene that must be interpreted in the context of your family history and physical features. I emphasise that test results should be discussed with your specialist to guide management.”
— Dr. PRABHAKAR REDDY (DHA License: 61713011), Clinical Geneticist
⚠️ Do not discontinue prescribed medication without consulting your doctor.
Safety & Exclusion Criteria
- Exclusion Criteria for Blood Collection: Active bleeding disorders, severe anaemia, or acute febrile illness. Home phlebotomy is performed by DHA-licensed professionals under aseptic conditions.
- Emergency Red Flags: If you or the patient experience sudden worsening of existing symptoms, severe difficulty breathing, seizures, or loss of consciousness, seek immediate emergency medical care and do not wait for test results.
- Minor Consent: Testing of minors (<18 years) strictly follows UAE CDS Law 2026; mandatory genetic counselling and legal guardian consent are required before sample collection.
Patient FAQ & Clinical Guidance
1. What is the HDAC8 gene Cornelia de Lange syndrome type 5 test and why is it done?
Snippet: This genetic test sequences the HDAC8 gene to detect mutations causing Cornelia de Lange syndrome type 5, aiding precise diagnosis.
It is indicated for individuals with clinical signs such as distinctive facial features, growth retardation, limb abnormalities, and hirsutism, or for family members at risk. The NGS test reads the full coding DNA sequence to identify pathogenic variants, confirming CdLS5 and differentiating it from other CdLS subtypes.
ملخص الإجابة: يقوم هذا الفحص الجيني بتحليل تسلسل جين HDAC8 للكشف عن الطفرات المسببة لمتلازمة كورنيليا دي لانج النوع الخامس، مما يساعد في تأكيد التشخيص السريري.
2. How accurate is this Genetic Test and how long does it take?
Snippet: With 99.9% analytical sensitivity and specificity, our NGS delivers reliable results within 3 to 4 weeks.
Our ISO-accredited laboratory follows stringent quality control, ensuring every nucleotide is interrogated multiple times. The turnaround time includes DNA extraction, library preparation, sequencing, bioinformatic analysis, and final clinical report signed by a certified geneticist.
ملخص الإجابة: يتمتع الاختبار بحساسية ونوعية تحليلية تصل إلى 99.9%، وتصدر النتائج الموثوقة خلال 3 إلى 4 أسابيع من استلام العينة.
3. What sample is required and is home collection available in the UAE?
Snippet: A single blood sample or dried blood spot on FTA card is sufficient, with hospital-grade home collection across UAE.
You may provide a standard venous blood sample (3–5 mL in EDTA tube) or one drop of blood on a special FTA card. Our VIP mobile phlebotomy team visits your home between 8 AM and 11 PM, using temperature-controlled transport to guarantee specimen integrity. All collections comply with UAE PDPL and health authority regulations.
ملخص الإجابة: يكفي أخذ عينة دم بسيطة أو نقطة دم على بطاقة FTA، وتتوفر خدمة السحب المنزلي المعتمدة في جميع أنحاء الإمارات.
UAE Regulatory Compliance
This service is delivered in strict accordance with Federal Decree-Law No. 41 of 2024 (Art. 87) on the practice of human medicine, the Child Data Safety (CDS) Law 2026 for minor protections, and the UAE Personal Data Protection Law (PDPL). All genetic data is encrypted, stored on secure servers within the UAE, and never shared without explicit consent. Facility License: 9834453. ISO 9001:2015 Certified.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians