Test Price
2,800 AEDโ Home Collection Available
GREM1 Gene Polyposis Syndrome, Hereditary Mixed Genetic Test in Dubai | 2800 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
This molecular diagnostic assay employs Next-Generation Sequencing (NGS) to detect germline mutations in the GREM1 gene associated with hereditary mixed polyposis syndrome (HMPS) and elevated colorectal cancer risk. The test delivers a diagnostic sensitivity of 99.9% under ISO 9001:2015 accredited processing (Cert: INT/EGQ/2509DA/3139). Logistics include VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Post-test telephonic clinical guidance for result interpretation is provided by a consultant medical geneticist. Direct billing verification is available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The GREM1 gene test identifies pathogenic variants that drive hereditary mixed polyposis syndrome, a condition that confers a significantly elevated lifetime risk of colorectal cancer. Full gene coverage including deletion and duplication analysis is performed using deep NGS, enabling comprehensive risk stratification for patients and their families. Results are delivered within 3โ4 weeks with a detailed clinical report that includes polyposis syndrome risk stratification and family management advice.
| Feature | Our Test (NGS Deep Sequencing) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision / Method | Full GREM1 gene coverage + deletion/duplication analysis | Targeted mutation hotspots only |
| Diagnostic Sensitivity | 99.9% | ~85โ90% |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Clinical Report | Includes polyposis syndrome risk stratification and family management advice | Basic mutation call with limited interpretation |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh โ Consultant Medical Genetics (DHA Registration ID: 9294403): โThis genetic test offers a high-resolution view of hereditary colorectal cancer susceptibility. A finding of a pathogenic GREM1 variant should prompt a tailored surveillance program that includes regular colonoscopy and family cascade screening. It is essential to note that a positive result indicates an elevated lifetime risk, not an immediate cancer diagnosis. All patients are strongly advised to review their results with a gastroenterologist or oncologist to develop a personalised clinical action plan.โ
Clinical Advisory Guidance
Pre-test genetic counselling is mandatory for this assay and will be arranged virtually prior to sample collection. Patients should provide a complete three-generation family history of colorectal cancer and polyposis to aid accurate variant classification. Do not discontinue any prescribed medication without consulting your referring physician. This test is not a substitute for routine colonoscopy or other colorectal cancer screening modalities.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals unwilling to complete pre-test genetic counselling; acute illness requiring immediate medical intervention; minors without legal guardian consent as per applicable UAE paediatric assent regulations.
- Emergency Red Flags (seek immediate medical attention): Sudden severe abdominal pain, rectal bleeding, unexplained weight loss, or a palpable abdominal mass.
Patient FAQ & Clinical Guidance
1. What is the GREM1 gene test and why is it performed?
The GREM1 gene test detects inherited mutations that cause hereditary mixed polyposis syndrome, a condition that significantly raises the risk of colorectal cancer. Identifying a pathogenic variant allows for early and intensive colonoscopy surveillance, risk-reducing measures, and cascade testing of at-risk relatives. The test aligns with DHA clinical oncology guidelines for hereditary cancer syndromes.
2. How should I prepare for the sample collection?
No special preparation such as fasting or medication adjustment is required. A blood sample or saliva specimen is collected by our mobile phlebotomy team at your home between 8 AM and 11 PM. If using an FTA card, a single drop of blood from a finger prick is sufficient. Mandatory pre-test genetic counselling will be arranged via telehealth before collection.
3. Does my health insurance cover the 2800 AED cost?
Many UAE health insurers cover genetic testing when medically indicated. Direct billing verification can be completed via WhatsApp at +971 54 548 8731. Send your insurance card details and we will confirm your coverage within one business day. Out-of-pocket payment options are also available.
4. How long does it take to receive results?
The standard turnaround time is 3โ4 weeks from sample receipt at the laboratory. This allows for full NGS sequencing, bioinformatics analysis, variant classification, and comprehensive clinical report generation. Results are delivered electronically and discussed during a telephonic session with a consultant medical geneticist.
UAE Regulatory & Data Privacy Adherence
All genetic data processing is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 9001:2015 accreditation (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143. Genetic information is encrypted, access-restricted, and never shared with third parties without explicit patient authorisation.
Clinical & Logistical Metadata
| Test Name | GREM1 Gene Polyposis Syndrome, Hereditary Mixed Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Saliva (Oragene DNA collection kit) |
| Methodology Used | Next-Generation Sequencing (NGS) with deletion/duplication analysis |
| ICD-10-CM Code | Z15.09 |
| LOINC Code | 93940-4 |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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