Test Price
2,800 AEDโ Home Collection Available
GPI Gene Hemolytic Anemia, Nonspherocytic, Due to Glucose Phosphate Isomerase Deficiency Genetic Test in UAE
Executive Summary & Core Metrics
This advanced genetic test uses Next Generation Sequencing (NGS) to diagnose GPI gene mutations with 99.9% diagnostic sensitivity. Our ISO 9001:2015 accredited laboratory, operating under DHA Facility License 1143, ensures reliable results. We offer VIP mobile phlebotomy and temperature-controlled cold-chain home collection (daily 8 AM โ 11 PM) along with telephonic post-test genetic counseling by our expert team.
- โ Accuracy: 99.9% Diagnostic Sensitivity via NGS & ISO 9001:2015
- โ Logistics: VIP Home Collection & Secure Courier โ 8 AM to 11 PM
- โ Guidance: Telephonic Post-Test Clinical Genetic Counseling
- โ Support: Direct Billing Verification via WhatsApp +971 54 548 8731
Price: 2,800 AED
Turnaround Time: 3 to 4 Weeks
Sample Type: Blood, Extracted DNA, or Dried Blood Spot (FTA Card)
Test Overview & Methodology
This genetic test analyzes the entire coding region of the GPI gene using Next Generation Sequencing (Illumina platform) to identify pathogenic variants causing glucose phosphate isomerase deficiency, a rare autosomal recessive disorder presenting as chronic nonspherocytic hemolytic anemia. Molecular confirmation differentiates it from other enzymopathies (e.g., pyruvate kinase deficiency) and guides precise clinical management, family planning, and genetic counseling.
| Feature | Our Test: GPI-NGS Panel | Closest Alternative: Single Enzyme Assay |
|---|---|---|
| Precision & Method | Full Gene Sequencing via NGS (Illumina Platform) | Biochemical enzyme activity measurement |
| Diagnostic Yield | >99% for point mutations, small indels, and exon-level copy number variants | ~85โ90%; may miss compensated or post-transfusion states |
| Clinical Speed | Definitive genotype in 3โ4 weeks | Faster TAT (1 week), but often requires reflex to genetic testing |
Physician Insight & Safety Protocols
"A positive GPI genetic result provides a molecular explanation for lifelong hemolytic anemia, but clinical correlation with hematological parameters and family history is essential. This test offers clarity and empowers precise genetic counseling regarding inheritance patterns and reproductive options. A negative result does not exclude other hereditary hemolytic anemias; further clinical investigation may be warranted."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
โ Critical Safety & Medication Advisory
Do not discontinue, adjust, or modify any prescribed medication or transfusion schedule based on this test order or result without explicit consultation with your managing physician. This genetic test is diagnostic; it does not replace emergency management.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Recent blood transfusion (within 21 days) may affect extracted DNA from whole blood; an FTA card or buccal swab is preferred. Not suitable for patients who have undergone allogeneic bone marrow transplant.
- Emergency Red Flags (Seek Immediate Care): Severe chest pain, acute shortness of breath, sudden drop in hemoglobin with pallor, or acute splenic sequestration crisis require emergency department attention. This 3โ4 week test is for diagnosis, not acute management.
Patient FAQ & Clinical Guidance
1. What sample is required for this GPI genetic test, and what preparation is essential?
The preferred sample is one blood spot on an FTA Card, or 3โ5 mL of whole blood in an EDTA tube. A pre-test genetic counseling session to draw a comprehensive family pedigree is medically essential for accurate interpretation. No special preparation like fasting is required.
2. How long do results take, and why compared to a standard enzyme test?
Results are delivered within 3 to 4 weeks because Next Generation Sequencing involves DNA library preparation, high-throughput sequencing on Illumina platforms, and comprehensive bioinformatics analysis to detect specific pathogenic variants in the GPI gene. Standard enzyme assays are faster but less definitive.
3. Will my health insurance in the UAE cover this genetic test?
Coverage for hereditary anemia panels depends on your policyโs outpatient genetic testing clause. Our dedicated team provides direct billing verification and pre-authorization support via WhatsApp at +971 54 548 8731 to confirm benefits before the test.
UAE Regulatory & Data Privacy Adherence
This test and its data handling are fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | GPI Gene Hemolytic Anemia, Nonspherocytic, Due to Glucose Phosphate Isomerase Deficiency Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Blood, Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) on Illumina Platform |
| ICD-10-CM Code | D55.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE DNA Labs UAE |
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