Test Price
2,800 AED✅ Home Collection Available
GLDC Gene Glycine Encephalopathy Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2022 & ISO 9001:2015 accredited processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed medical geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Turnaround Time: 21 working days from sample receipt.
Test Type: Targeted NGS (Next Generation Sequencing) of GLDC gene coding regions.
Regulatory Compliance: DHA Licensed Facility No. 1143.
Sample Requirements: Whole blood (EDTA) or buccal swab.
Test Overview & Methodology
Overview: Decoding GLDC & Nonketotic Hyperglycinemia
The GLDC Gene NGS test identifies pathogenic variants causing glycine encephalopathy (nonketotic hyperglycinemia, ICD-10-CM E72.21) – a severe neonatal metabolic crisis. This DHA-aligned assay offers definitive molecular diagnosis for at-risk families, with results ready in 21 working days.
The test employs targeted next-generation sequencing (NGS) of all coding exons and flanking intronic regions of the GLDC gene, with ML-driven variant interpretation according to ACMG guidelines. Analytical sensitivity exceeds 99.9% for single nucleotide variants and small indels.
| Feature | Our Test (GLDC Targeted NGS) | Closest Alternative (WES/CMA) |
|---|---|---|
| Precision | 99.9% analytical sensitivity for GLDC coding regions | 60–80% detection in broad panels; may miss deep intronic variants |
| Methodology | NGS with ML-driven variant interpretation (HGMD-compatible) | Whole Exome Sequencing / Chromosomal Microarray – incidental findings risk |
| Speed | 21 working days from receipt with same-day reporting | 4–6 weeks, often delayed by reflex testing |
Physician Insight & Safety Protocols
“A positive GLDC mutation result demands urgent multidisciplinary management: metabolic crisis can appear within hours of birth. I strongly advise all families to consult a clinical geneticist post-test and never halt any prescribed metabolic therapy without medical supervision. This test provides diagnostic clarity, not a treatment plan.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ Medication Warning: Do not discontinue prescribed medication without consulting your doctor. This test identifies genetic risk; it does not supersede urgent medical therapy.
Exclusion Criteria & ER Red Flags
- Active metabolic decompensation: Do not postpone emergency care for sample collection; the test is not for acute crisis diagnosis.
- Inadequate sample: Whole blood must be collected in EDTA/DNA-stabilising tubes; clotted or haemolysed samples will be rejected.
- Non-consented minors: In compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability, all paediatric tests require legal guardian consent and DHA-approved genetic counselling.
- ER Signs: Seizures, coma, hypotonia, respiratory distress – call 998 immediately and alert your metabolic physician.
Patient FAQ & Clinical Guidance
1. What does the GLDC NGS test detect, and why is it ordered?
This test sequences the entire GLDC gene coding regions to identify pathogenic variants responsible for glycine encephalopathy, a life-threatening neonatal neurometabolic disorder. It is typically ordered when there is clinical suspicion of nonketotic hyperglycinemia, family history, or abnormal newborn screening results.
2. How is the sample collected, and is home collection available in Dubai?
Our ISO-certified phlebotomists provide hospital-grade home blood draw (or buccal swab/FTA card) across all UAE emirates between 8 AM and 11 PM daily. The sample must be collected in EDTA tubes for whole blood or sterile buccal swabs for non-invasive collection.
3. Will my insurance cover this genetic test, and how do I verify?
Direct billing with major UAE insurers is supported; send your policy details via WhatsApp to +971 54 548 8731 for instant eligibility confirmation. Coverage is subject to your insurance plan’s genetic testing benefit.
4. How long will results take, and how are they delivered?
Results are delivered within 21 working days from sample receipt. You will receive a comprehensive report via secure email or patient portal, followed by a telephonic consultation with a DHA-licensed medical geneticist to discuss findings and recommendations.
UAE Regulatory & Data Privacy Adherence
Legal Compliance: This test is performed under the regulatory purview of the Dubai Health Authority (DHA) Facility License No. 1143. All clinical data handling adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and privacy are paramount; genetic information is stored securely and accessible only to authorized medical personnel.
Accreditation: Our laboratory holds ISO 9001:2015 (Certificate: INT/EGQ/2509DA/3139) for quality management, and all genetic testing follows ISO 15189:2022 standards for clinical laboratories.
Clinical & Logistical Metadata
| Test Name | GLDC Gene Glycine Encephalopathy Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21 working days |
| Sample Type / Matrix | Whole blood (EDTA) or buccal swab |
| Methodology Used | Targeted NGS (Next Generation Sequencing) |
| ICD-10-CM Code | E72.21 |
| LOINC Code | 83084-7 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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