Test Price
2,800 AED✅ Home Collection Available
GLA Gene Fabry Disease Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
99.9% Diagnostic Accuracy
Definitive molecular diagnosis for Fabry disease via NGS with CNV detection. Home collection available daily 8 AM to 11 PM. Post-test genetic counselling by DHA-licensed Consultant Medical Genetics.
VIP Mobile Phlebotomy & Cold-Chain Home Collection
ISO-certified logistics, daily 8 AM – 11 PM. Whole blood, extracted DNA, or FTA card accepted.
Post-Test Clinical Guidance
Telephonic interpretation support by DHA-licensed Consultant Medical Genetics (DHA: 9294403).
Test Overview & Methodology
The GLA Gene Fabry Disease Genetic Test utilizes next‑generation sequencing (NGS) to analyze the complete coding region and exon‑intron boundaries of the alpha‑galactosidase A (GLA) gene. This assay detects pathogenic single nucleotide variants, small insertions/deletions, and copy number changes, delivering a definitive molecular diagnosis for Fabry disease, an X‑linked lysosomal storage disorder affecting the heart, kidneys, and nervous system.
| Feature | Our GLA NGS Test | Closest Alternative (Enzyme Assay + Single‑Gene Sanger) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) with CNV detection; full gene coverage | Enzymatic activity assay ± targeted Sanger sequencing of common variants |
| Diagnostic Sensitivity | >99.9% for sequence and copy number variants (ISO‑validated pipeline) | ~85‑90% for known mutations; may miss deep intronic or novel variants |
| Turnaround Time | 3–4 weeks | Enzyme: 1–2 weeks; Sanger: 2–4 weeks (if performed) |
| Sample Options | Whole blood, Extracted DNA, or One‑drop blood on FTA Card | Whole blood (enzyme); blood or DNA (Sanger) |
| Price | 2,800 AED (all‑inclusive home collection & report) | Often higher when combined; not fully covered |
Physician Insight & Safety Protocols
Note from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403): “As a Consultant Medical Geneticist, I emphasize that a negative GLA NGS result does not exclude Fabry disease if clinical suspicion remains high. Positive results must be correlated with symptoms and family history. Our team is here to support you throughout.”
Advisory: Do Not Discontinue Prescribed Therapy
This test is a diagnostic tool only. Do not stop enzyme replacement therapy or any prescribed medication without consulting your managing physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Acute febrile illness on the day of sample collection; uncooperative minor without legal guardian consent (informed consent per Federal Decree-Law No. 4 of 2016); inadequate sample volume.
- Emergency Red Flags: Sudden severe burning pain in hands/feet (acroparesthesia), chest pain with palpitations, transient ischaemic attack or stroke-like symptoms, or acute renal failure – seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is the GLA Gene Fabry Disease NGS Test and what does it detect?
The test uses next-generation sequencing to examine the entire GLA gene for mutations that cause Fabry disease. It detects single nucleotide variants, small insertions/deletions, and larger copy number changes, providing a conclusive molecular diagnosis when symptoms or low enzyme activity are present.
2. Who should consider taking this genetic test in the UAE?
Consider this test if you have unexplained proteinuria, burning pain in hands/feet, heat intolerance, angiokeratomas, or a known family history of Fabry disease. It is also recommended for carrier screening in at-risk females and for confirming borderline enzyme results. UAE physicians often refer individuals with early‑onset stroke, left ventricular hypertrophy, or kidney failure of unknown cause.
3. How reliable is this test and when can I expect results?
Our GLA NGS assay delivers 99.9% diagnostic sensitivity for sequence and copy number variants, analysed in an ISO 9001:2015 certified facility. Results are typically available within 3 to 4 weeks. Every variant is classified per ACMG guidelines, and reports include clinical correlation recommendations. We provide secure online report access and a post-test consultation with a DHA-licensed specialist at no extra cost.
UAE Regulatory & Data Privacy Adherence
- Data Privacy: Fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL). Genomic data is encrypted and stored securely.
- Health Information Governance: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Medical Liability: All clinical procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring informed consent and patient safety.
- Genetic Counselling: Pre- and post-test counselling provided by DHA-licensed Consultant Medical Genetics (DHA: 9294403).
- Sample Collection: VIP mobile phlebotomy or secure courier for solid specimens. Home collection under cold-chain protocol daily 8 AM – 11 PM.
- Insurance Verification: Direct billing support. Send card via WhatsApp to +971 54 548 8731 for instant eligibility.
- Accreditation: ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | GLA Gene Fabry Disease Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV detection |
| ICD-10-CM Code | E75.21 (Fabry disease), Z15.89 (genetic susceptibility), Z84.89 (family history) |
| LOINC Code | 21687-4 (GLA gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians