Test Price
2,800 AED✅ Home Collection Available
GFM2 Gene Microcephaly with Simplified Gyral Pattern and Insulin-Dependent Diabetes Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS-based test analyzes the GFM2 gene to diagnose the rare autosomal recessive syndrome of microcephaly with simplified gyral pattern and insulin-dependent diabetes. The test uses targeted next-generation sequencing (Illumina) with confirmatory Sanger sequencing to ensure 99.9% diagnostic sensitivity for pathogenic variants in the GFM2 gene.
| Feature | Our GFM2 Targeted NGS Test | Whole Exome Sequencing (Alternative) |
|---|---|---|
| Precision | High-depth targeted sequencing with Sanger validation | Broad coverage but lower per-gene depth |
| Methodology | NGS (Illumina) + confirmatory Sanger | Whole exome capture + NGS |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Cost (AED) | 2800 | ~5000 |
| Regulatory Compliance | DHA Licensed (1143) & ISO 9001:2015 | Varies by provider |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I recognize the profound emotional impact that awaiting a genetic diagnosis can have on families. This targeted GFM2 gene test provides definitive molecular confirmation for microcephaly with simplified gyral pattern and insulin-dependent diabetes, enabling precise clinical management. However, results must always be correlated with a detailed clinical evaluation, pedigree analysis, and counseling. If you observe any signs of neurological decline or metabolic instability in your child, seek immediate medical attention.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Guidance
Do not discontinue or adjust any prescribed diabetes medication or neurological treatment without direct consultation with your treating physician. This genetic test is diagnostic and does not replace ongoing clinical monitoring for hyperglycemia, seizures, or developmental regression. Always keep emergency contacts accessible for acute symptoms.
Exclusion Criteria
- Not intended for asymptomatic general population screening.
- Sample must be collected by a trained professional to avoid contamination.
- Immediate medical attention is required if the child experiences severe hyperglycemia (nausea, vomiting, fruity breath) or neurological deterioration (lethargy, seizures) – these are unrelated to the blood draw but critical for diabetic management.
Patient FAQ & Clinical Guidance
1. What is the GFM2 gene and associated syndrome?
GFM2 gene mutations cause microcephaly with simplified gyral pattern and insulin-dependent diabetes, a rare autosomal recessive disorder. This condition affects brain development and insulin production, requiring lifelong management by a multidisciplinary team.
2. How is the test performed and what sample is required?
A peripheral whole blood sample (3–5 mL in EDTA tube) or DNA extracted from an FTA card is analyzed using next-generation sequencing (NGS) with Sanger confirmatory sequencing. Our VIP Mobile Phlebotomy service ensures convenient home collection between 8 AM and 11 PM, adhering to strict cold-chain protocols.
3. What do the results mean, and what are the turnaround time and costs?
A positive result confirms the diagnosis of GFM2-related syndrome; a negative result significantly reduces the likelihood but requires clinical correlation. The turnaround time is 3–4 weeks from sample receipt, and the total cost is 2,800 AED, which includes the genetic analysis and telephonic post-test counseling.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
This genetic test is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is encrypted, access-controlled, and processed under ISO 9001:2015 certified protocols within the UAE.
Clinical & Logistical Metadata
| Test Name | GFM2 Gene (Microcephaly with Simplified Gyral Pattern and Insulin-Dependent Diabetes) Targeted NGS Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card (DNA) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmatory Sequencing |
| ICD-10-CM Code | Q02, E10.9, Z15.89 |
| LOINC Code | 82939-0 |
| DHA Facility License & Laboratory Address | License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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