Test Price
2,800 AED✅ Home Collection Available
GFAP Gene Alexander Disease Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Whole Gene Sequencing. Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM). Clinical Guidance: Telephonic Post-Test Interpretation by a Consultant Medical Geneticist. Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731. Turnaround Time: 3–4 weeks from sample receipt.
Test Overview & Methodology
The GFAP Gene Alexander Disease Genetic Test is a comprehensive next‑generation sequencing (NGS) analysis targeting the entire coding region of the glial fibrillary acidic protein (GFAP) gene – the only known causative gene for Alexander disease, a rare progressive leukodystrophy often presenting in infancy or adulthood with spasticity, ataxia, and megalencephaly. This test empowers clinicians and families with a definitive molecular diagnosis, enabling early intervention, reproductive planning, and targeted management.
| Feature | Our Test (Precision NGS) | Closest Alternative (Sanger/MLPA) |
|---|---|---|
| Methodology | NGS (Whole Gene Sequencing) | Targeted analysis / single‑site |
| Diagnostic Sensitivity | 99.9% (point mutations, indels, CNVs) | Up to 85% (misses deep intronic/CNV) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Relevance | Fully aligned with ICD‑10 G31.89 & LOINC 92550-1 | May require reflexive testing |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I see the profound impact that a definitive molecular diagnosis can have on families navigating a suspected leukodystrophy. This whole gene NGS test offers exceptional sensitivity for GFAP mutations, but results must always be correlated with clinical presentation and imaging. I strongly encourage pre- and post-test genetic counseling to ensure informed decisions and accurate interpretation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Pre-Test Genetic Counseling & Informed Consent
Required Before Sample Collection:
A formal genetic counseling session must be completed to document pedigree, discuss inheritance patterns (autosomal dominant with reduced penetrance), and obtain written informed consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability. No fasting or medication changes are necessary. Continue all prescribed treatments unless otherwise instructed.
Exclusion Criteria & Emergency Red Flags
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals under 18 years without legal guardian consent; inability to provide informed consent; non‑medical curiosity testing with no clinical indication or referral.
- Emergency Red Flags: Sudden or severe worsening of weakness, seizures, difficulty breathing, altered consciousness, or acute neurological deterioration → Seek immediate ER evaluation; genetic test results will not alter acute care.
Patient FAQ & Clinical Guidance
1. What is the GFAP gene Alexander disease test?
The GFAP gene Genetic Test uses next‑generation sequencing to identify single nucleotide variants, small insertions/deletions, and copy number variations across the entire GFAP gene. It provides a definitive molecular diagnosis when clinical suspicion is high, offering unmatched diagnostic sensitivity for Alexander disease.
2. How long does it take to get results?
Turnaround time is 3 to 4 weeks from sample receipt. This includes DNA extraction, library preparation, sequencing, bioinformatics analysis, and clinical interpretation by our board‑certified medical geneticist.
3. Who should consider this test?
Individuals with clinical symptoms of leukodystrophy, family history of Alexander disease, or suspicious MRI findings of white matter abnormalities should consider this test after genetic counseling. It is especially recommended for patients presenting with infantile macrocephaly, progressive spasticity, and ataxia, as well as for at‑risk family members seeking clarity.
4. What sample is required and how is it collected?
Accepted sample types: Whole Blood (EDTA), Extracted DNA, or one drop of blood on an FTA card. Our VIP Mobile Phlebotomy service collects samples at your home between 8 AM and 11 PM daily, using temperature‑controlled cold‑chain logistics. Alternatively, you may visit our Dubai Healthcare City facility.
5. How are results delivered and interpreted?
Results are delivered electronically via a secure patient portal and include a detailed clinical report. A telephonic post‑test consultation with our Consultant Medical Geneticist is provided to explain findings, implications, and recommended next steps.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
This service fully adheres to the following UAE federal frameworks:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – all genetic data is encrypted and stored locally in the UAE.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensures secure electronic health records and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – governs informed consent and clinical responsibility for genetic testing.
DNA Labs UAE operates under DHA Facility License No. 1143, ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). All genetic testing is performed in accredited laboratories.
Clinical & Logistical Metadata
| Test Name | GFAP Gene Alexander Disease Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next‑Generation Sequencing (NGS) – Whole Gene Sequencing |
| ICD-10-CM Code | G31.89 (Other specified degenerative diseases of nervous system) |
| LOINC Code | 92550-1 (GFAP gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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