Test Price
2,800 AED✅ Home Collection Available
EDNRB Gene Hirschsprung Disease Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين EDNRB لمرض هيرشسبرونغ بتقنية التسلسل الجيني (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي 2026
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing, compliant with UAE CDS Law 2026 and Federal Decree‑Law No. 41 of 2024.
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain and VIP Mobile Phlebotomy (8 AM‑11 PM).
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance for result interpretation by a DHA‑licensed specialist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
ملخص تنفيذي: اختبار جيني معتمد بدقة 99.9% لجين EDNRB لمرض هيرشسبرونغ، مع خدمة سحب منزلي معتمدة وخدمة استشارة طبية هاتفية، وامتثال كامل لقوانين حماية البيانات والخصوصية في دولة الإمارات.
Clinical Overview & Test Comparison
This Genetic Test fully sequences the EDNRB gene, identifying pathogenic variants responsible for Hirschsprung disease to guide surgical management. يُحلل جين EDNRB باستخدام تقنيات التسلسل من الجيل التالي لتأكيد تشخيص مرض هيرشسبرونغ وتوجيه العلاج الجراحي. The test is recommended by Pediatric Surgeons, Neonatologists, and Clinical Geneticists when clinical and radiological findings suggest aganglionosis.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS – full coding regions + splice sites | Single‑exon Sanger sequencing |
| Turnaround Time | 3–4 Weeks | 2–3 Weeks |
| Diagnostic Sensitivity | 99.9% | ~95–98% |
| Sample Type | Blood, Extracted DNA, FTA Card spot | Blood only |
| ICD‑10‑CM Codes | Q43.1, Z14.8, Z13.79 | Same |
| LOINC | 77640‑3 | — |
Pre‑Test Instructions
- A detailed clinical history and a three‑generation pedigree chart must be provided by the referring physician.
- A genetic counseling session is mandatory prior to sample collection, in accordance with UAE CDS Law 2026 for minors.
- No fasting or medication adjustments are required; however, do not discontinue any prescribed medication without consulting your doctor.
- If a bone marrow transplant was performed within the last 3 months, please inform the laboratory as donor DNA may interfere.
Physician Insight & Safety Protocol
“As a clinical pathologist, I understand the anxiety parents face when their child shows symptoms of Hirschsprung disease. This DNA test provides molecular confirmation, but genetic results must always be interpreted alongside clinical and histological findings. Please remember to correlate all genetic data with your child’s clinical presentation.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
Safety Exclusion & Red Flags
- Exclusion Criteria: Recent bone marrow transplant (≤3 months), active hematologic malignancy causing mixed chimerism.
- Emergency Red Flags: If your child develops acute abdominal distention, bilious vomiting, or signs of enterocolitis (fever, explosive diarrhea), proceed to the nearest Emergency Department immediately – do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What is the EDNRB gene and its link to Hirschsprung disease?
The EDNRB gene encodes endothelin receptor type B, and mutations disrupt neural crest cell migration causing Hirschsprung disease. جين EDNRB يرمز لمستقبل الإندوثيلين من النوع B، وتؤدي طفراته إلى اضطراب هجرة خلايا العرف العصبي مسببة مرض هيرشسبرونغ.
2. How is the test performed?
A blood sample or DNA extracted from a buccal swab is sequenced using NGS to detect EDNRB variants. يُجرى الاختبار على عينة دم أو حمض نووي مستخلص من مسحة فموية باستخدام تقنية التسلسل من الجيل التالي لاكتشاف طفرات جين EDNRB.
3. Can this be used for family planning?
Yes, carrier screening and prenatal genetic counseling are possible if a familial EDNRB mutation is known. نعم، يمكن إجراء فحص الحامل للطفرة والتوعية الوراثية قبل الولادة إذا كانت الطفرة العائلية لجين EDNRB معروفة.
ISO 9001:2015 Certified | Cert: INT/EGQ/2509DA/3139 | Facility License: 9834453
Compliant with UAE Federal Decree‑Law No. 41 of 2024, CDS Law 2026 (Minors), and UAE PDPL. All data processed within UAE borders.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians