Test Price
2,800 AED✅ Home Collection Available
DSPP Gene Dentinogenesis Imperfecta Shields Type 3 Genetic Test in UAE | AED 2,800 | DNA Labs UAE
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – Next-Generation Sequencing (NGS) with full DSPP gene coverage, certified under ISO 9001:2015.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection – Available daily from 8 AM to 11 PM across Dubai and the UAE.
- Complimentary Post-Test Genetic Counseling – Telephonic consultation with a DHA-licensed Consultant Medical Genetics specialist included at no extra charge.
- Insurance Direct Billing – Verify your coverage instantly via WhatsApp at +971 54 548 8731.
- DHA Licensed Facility – Premises 105, Floor 1, Building 33, Dubai Healthcare City, under DHA Facility License 1143.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the DSPP gene to detect pathogenic variants causing Dentinogenesis Imperfecta Shields Type 3, an inherited autosomal dominant disorder affecting tooth enamel and dentin development. The test provides definitive molecular diagnosis for individuals presenting with clinical symptoms, enables accurate recurrence risk assessment, and supports personalized dental, dermatologic, and orthopedic management plans. Full coding region and exon-intron boundary coverage ensures detection of single nucleotide variants, small insertions and deletions, and splice-site alterations at >99.9% analytical sensitivity.
| Feature | DNA Labs UAE NGS Test | Alternative Sanger Sequencing |
|---|---|---|
| Technology | Next-Generation Sequencing (NGS) – full gene, all coding exons + flanking intronic regions | Sanger sequencing, limited to known mutational hotspots |
| Detection Sensitivity | >99.9% for SNVs and small indels | ~95%; may miss deep intronic or large deletion variants |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Genetic Counseling | Pre- and post-test consultation included | Often not bundled; separate referral required |
| Regulatory Compliance | DHA Licensed, ISO 9001:2015, UAE PDPL, Federal Law No. 2 of 2019 | Variable by laboratory |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I recognize that receiving a molecular diagnosis for a rare heritable dental condition can evoke significant emotional and practical concerns. This NGS-based DSPP gene analysis delivers a high-confidence result that must always be interpreted in the context of complete clinical findings, three-generation pedigree, and dental history. A pathogenic variant is not deterministic — comprehensive restorative dental care, regular dermatologic surveillance, and informed family planning substantially improve long-term outcomes. Pre-test genetic counseling is not merely recommended; it is a prerequisite for autonomous patient decision-making.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Pre-Test Safety Advisory
- Mandatory Informed Consent: All patients must complete a pre-test genetic counseling session to discuss inheritance pattern, test limitations, potential incidental findings, and psychosocial impact before sample collection.
- Medication Disclosure: Provide a complete list of current medications and supplements to the phlebotomist. Do not discontinue any prescribed therapy without prior consultation with your treating physician.
- Clinical Documentation: Submit detailed dental, dermatologic, and family history records, including a pedigree chart, prior to sample collection.
- Sample Collection Protocol: One EDTA whole blood tube (3–5 mL) or one FTA card with a single blood spot is sufficient. No fasting or dietary preparation is required.
Clinical Exclusion Criteria
- Bleeding Diatheses: Active bleeding disorders or severe anemia that contraindicate venipuncture. Alternative sample types (FTA card or extracted DNA) may be considered after physician evaluation.
- Inability to Consent: Patients unable to provide autonomous informed consent must be accompanied by a legal guardian. Minors require parental/guardian consent and a pediatric genetic counseling referral in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Recent Blood Transfusion: Whole blood samples collected within 30 days of a transfusion may yield false negative results due to donor DNA admixture. Defer testing or use an FTA card with buccal cells.
Patient FAQ & Clinical Guidance
1. What is the DSPP gene test for dentinogenesis imperfecta Shields type 3?
This NGS-based test detects pathogenic variants in the DSPP gene responsible for Dentinogenesis Imperfecta Shields Type 3, a rare autosomal dominant disorder affecting tooth structure and development. The test sequences the entire coding region and exon-intron boundaries to identify single nucleotide variants, small insertions and deletions, and splice-site alterations with high precision. Results enable definitive diagnosis, inform restorative dental treatment planning, anticipate associated skin and bone manifestations, and guide reproductive counseling.
2. Why is genetic counseling required before the test?
Genetic counseling ensures that every patient provides fully informed consent after understanding inheritance patterns (autosomal dominant, 50% recurrence risk), potential outcomes of testing, and the psychosocial implications of a positive or negative result. A certified genetic counselor documents a three-generation pedigree, assesses for other hereditary dental or connective tissue disorders, and explains the scope of actionable findings. This step is mandated by UAE medical liability regulations (Federal Decree-Law No. 4 of 2016) to protect patient autonomy and safeguard minor participants.
3. How do I prepare for the DSPP gene DNA test?
After completing the mandatory genetic counseling session, you will submit a whole blood sample (EDTA tube) or an FTA card. No fasting or dietary changes are needed. Our mobile phlebotomist will collect the sample at your home or office using temperature-controlled cold-chain logistics between 8 AM and 11 PM daily. Provide a detailed medical history and completed pedigree form before collection. Turnaround time is 3–4 weeks from sample receipt at the laboratory. Results are delivered electronically, followed by a complimentary telephonic consultation with the genetics specialist.
UAE Regulatory & Data Privacy Adherence
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic sequence data, clinical records, and personal identifiers are encrypted at rest and in transit, stored on secure servers within the UAE, and access-restricted to authorized personnel only.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Digital health information systems comply with UAE standards for electronic medical records, data exchange, and audit trail logging.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Patient consent, pre-test counseling, and reporting of incidental findings adhere to the UAE framework for medical liability and patient safety.
- ISO 9001:2015 Quality Management Certification: Cert. INT/EGQ/2509DA/3139, ensuring rigorous quality control in pre-analytical, analytical, and post-analytical phases.
- DHA Facility License 1143: Operated under the regulatory oversight of the Dubai Health Authority at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | DSPP Gene Dentinogenesis Imperfecta Shields Type 3 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – full coding region and exon-intron boundaries |
| ICD-10-CM Code | K00.5 |
| LOINC Code | 94299-7 |
| DHA Facility License & Laboratory Address | DHA License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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