Test Price
2,800 AEDโ Home Collection Available
DMP1 Gene Autosomal Recessive Hypophosphatemic Rickets Type 1 (ARHR1) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Core Clinical Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Post-Test Telephonic Clinical Guidance for Result Interpretation by DHA-Licensed Genetic Specialist.
- Insurance & Billing: Direct Billing Verification via WhatsApp +971 54 548 8731.
Strictly aligned with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. ISO 9001:2015 Certified Facility License: 1143 (Dubai Healthcare City).
Test Overview & Methodology
This Genetic Test analyzes the entire DMP1 gene to detect pathogenic variants responsible for autosomal recessive hypophosphatemic rickets type 1 (ARHR1), a rare hereditary disorder of phosphate regulation causing severe bone deformities and short stature. The test employs Next Generation Sequencing (NGS) combined with ML-aligned variant interpretation to identify known and novel mutations across full coding regions, splice sites, and deep intronic regions.
| Feature | Our DMP1 NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Gene Coverage | Full coding region, splice sites, and deep intronic regions | Selected exons only |
| Sensitivity for Rare Variants | >99.9% detection of known and novel mutations | ~95% limited to predefined regions |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Cost (AED) | 2,800 | 2,500โ3,500 |
Physician Insight & Safety Protocols
โThis genetic test provides a critical piece of the diagnostic puzzle for ARHR1, but it must be interpreted alongside serum phosphate, FGF23 levels, and skeletal imaging. As a Consultant Medical Geneticist, I emphasise that a positive result confirms the diagnosis, enabling targeted therapy with phosphate and calcitriol. However, a negative result does not exclude other hypophosphatemic disorders. Our multidisciplinary team is committed to supporting you with precision and empathy throughout the journey.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue or adjust any prescribed medication (including phosphate supplements or active vitamin D) without consulting your treating physician. Abrupt changes may trigger severe metabolic imbalances such as hypocalcemia or hypercalcemia.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Recent blood transfusion (within 4 weeks) may compromise DNA integrity; severe anemia that contraindicates venipuncture; inability to provide informed consent (parent/guardian for minors).
- Seek immediate medical attention if you experience: acute bone pain or new fractures, tetany or muscle spasms (sign of hypocalcemia), severe chest wall deformity causing breathing difficulty, or sudden visual changes.
Patient FAQ & Clinical Guidance
1. What is the DMP1 gene NGS test and why do I need it?
This test sequences the entire DMP1 gene to identify disease-causing mutations for autosomal recessive hypophosphatemic rickets, enabling accurate diagnosis and personalised treatment. It helps distinguish ARHR1 from other phosphate-wasting disorders and guides targeted therapy with phosphate and calcitriol. A genetic counselling session to review family history is recommended before testing.
2. How should I prepare for the DMP1 gene test and what sample is required?
You must schedule a pre-test genetic counselling session to draw a pedigree chart and provide complete clinical history of the affected individual. We accept blood collected by our certified phlebotomist, extracted DNA, or a single drop of blood on an FTA card. No fasting or medication changes are required, but please inform us about any recent blood transfusions.
3. Will my genetic data be kept confidential and what do the results mean?
Your genetic information is protected under UAE Personal Data Protection Law (PDPL) and processed exclusively in our ISO-certified facility. A positive result indicates the presence of a DMP1 mutation, confirming ARHR1, which helps tailor phosphate dosing and long-term monitoring. A negative result may necessitate evaluation for other hypophosphatemic disorders. All results are interpreted by a DHA-licensed clinical geneticist.
UAE Regulatory & Data Privacy Adherence
Comprehensive Regulatory Compliance
This test and the handling of your genetic data strictly comply with the following UAE federal regulations:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring the confidentiality and security of your genetic information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing the safe and ethical use of digital health data.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ governing patient consent and clinical safety standards.
DNA Labs UAE operates under DHA Facility License Number 1143 and is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). All testing is performed in our Dubai Healthcare City laboratory.
Clinical & Logistical Metadata
| Test Name | DMP1 Gene Autosomal Recessive Hypophosphatemic Rickets Type 1 (ARHR1) Genetic Test โ NGS |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Extracted DNA or FTA Card โ VIP Mobile Phlebotomy Available |
| Methodology Used | Next Generation Sequencing (NGS) with ML-aligned variant interpretation |
| ICD-10-CM Code | E83.31, Z13.79, Z82.79 |
| LOINC Code | 79692-0 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians