Test Price
2,800 AEDโ Home Collection Available
DLX5 Gene Split-Hand/Foot Malformation Type 1 with Sensorineural Hearing Loss Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Next Generation Sequencing (NGS) Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counseling for comprehensive result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The DLX5 Gene NGS Test identifies pathogenic mutations associated with Split-Hand/Foot Malformation Type 1 (SHFM1) and sensorineural hearing loss, enabling early diagnosis and targeted clinical intervention for at-risk neonates and family members. This test leverages high-depth Next Generation Sequencing for comprehensive analysis of the entire coding region and splice sites, ensuring clinical-grade diagnostic precision unattainable by traditional methods.
| Feature | DNA Labs UAE โ NGS Panel | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) โ full gene coding regions & splice sites at high depth | Sanger sequencing โ limited exon-by-exon approach |
| Diagnostic Sensitivity | >99.9% for pathogenic variants (including deep-intronic) | ~95% due to missed deep-intronic and structural variants |
| Turnaround Time | 3โ4 Weeks | 5โ6 Weeks |
| Price (AED) | 2,800 AED (all-inclusive report & counseling) | Not directly comparable (limited clinical utility) |
Physician Insight & Safety Protocols
โAs a Consultant Medical Genetics specializing in hereditary limb malformations and pediatric hearing loss syndromes, I emphasize that comprehensive NGS-based analysis of DLX5 is crucial for accurate molecular diagnosis and informed family planning. This test provides a definitive etiological answer, enabling targeted surveillance, surgical planning, and early audiological intervention for affected children.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Prerequisite: Genetic Counseling Advisory
A pre-test genetic counseling session is mandatory for all patients prior to sample collection. This session ensures that the patient or legal guardian understands the scope of the genetic analysis, potential incidental findings, and the implications of results for family members. Informed consent must be documented in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Post-test, a dedicated telephonic counseling session is provided to discuss clinical management pathways and reproductive options.
Safety Exclusions & Emergency Red Flags
- Exclusion Criteria for Home Collection: Active severe bleeding disorder (hemophilia, platelet dysfunction) not under medical control; inability to safely collect venous blood; severe agitation or behavioral crisis precluding safe phlebotomy in a home setting.
- Emergency Red Flags: If the patient develops sudden worsening of respiratory distress, cyanosis, or uncontrollable bleeding from a surgical site, seek immediate emergency care at the nearest UAE hospital or call 998.
Patient FAQ & Clinical Guidance
1. What sample types are accepted for the DLX5 NGS test, and how is the collection performed in the UAE?
This DNA test accepts whole blood, extracted DNA samples, or a single drop of blood on an FTA card. Collection is performed by our accredited medical technicians via VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection across Dubai, Abu Dhabi, and Sharjah. Hospital-based collection is also available at our Dubai Healthcare City facility.
2. Is a genetic counselling session mandatory before taking the test, and what does it involve?
Yes, a pre-test genetic counselling session is mandatory. This session involves drawing a detailed three-generation pedigree chart to assess the inheritance pattern of SHFM1 and hearing loss, discussing the potential outcomes, and obtaining documented informed consent as mandated by UAE medical liability regulations.
3. How are the test results delivered, and who interprets them for clinical decisions?
Results are delivered via a secure digital portal within the stated turnaround time. A comprehensive molecular report is issued, and a telephonic post-test genetic counseling session with a DHA-licensed Consultant Medical Geneticist is included to explain the implications for the patientโs clinical care and family planning.
UAE Regulatory & Data Privacy Adherence
Your data is protected under the strictest UAE federal frameworks:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Governing the secure collection, processing, and storage of your personal and genetic information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Regulating the digital infrastructure, telemedicine counseling, and secure electronic health records used during your diagnostic journey.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Ensuring all clinical procedures, including pre-test counseling and sample collection, adhere to the highest standards of medical consent and patient safety.
Clinical & Logistical Metadata
| Test Name | DLX5 Gene Split-Hand/Foot Malformation Type 1 NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next Generation Sequencing (NGS) โ Full Gene Coding & Splice Site Analysis |
| ICD-10-CM Code | Q71.6, Q72.5, Q73.8, H90.3 |
| LOINC Code | 93711-0 |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians