Test Price
2,800 AED✅ Home Collection Available
DEPDC5 Genetic Test for Familial Focal Epilepsy with Variable Foci (NGS) in UAE – 2800 AED
Executive Summary & Core Metrics
DNA Labs UAE offers the DEPDC5 Next‑Generation Sequencing (NGS) test for familial focal epilepsy with variable foci, achieving a diagnostic sensitivity of 99.9% in accordance with ISO 9001:2015 standards. The service includes VIP mobile phlebotomy with temperature‑controlled cold‑chain home collection, comprehensive pre‑ and post‑test genetic counselling, and DHA‑compliant pedigree analysis. Final results are delivered within 3–4 weeks, and insurance coverage can be verified via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This test analyses the full coding sequence and exon‑intron boundaries of the DEPDC5 gene using next‑generation sequencing at ≥200× coverage, including copy number variation (CNV) detection. It identifies pathogenic variants responsible for familial focal epilepsy with variable foci, guiding antiepileptic therapy, family risk assessment, and personalised neurological management under DHA genomic medicine standards.
| Feature | Our DEPDC5 NGS Test | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (full gene sequencing & CNV detection) | ~95% (may miss large deletions/duplications) |
| Methodology | Next‑Generation Sequencing (NGS) with ≥200x coverage | Sanger sequencing of selected exons only |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Pre‑ & Post‑Test Genetic Counselling | Included (DHA‑compliant pedigree analysis) | Often not included |
| Price (AED) | 2,800 | Varies (may be higher with added counselling) |
Physician Insight & Safety Protocols
“As a consultant medical geneticist practicing in the UAE, I emphasise that a DEPDC5 mutation finding provides crucial molecular insight into familial focal epilepsy. However, this result must always be interpreted together with the full clinical history and electrographic data. Never adjust seizure medications without direct guidance from your treating neurologist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory – Medication Caution
Do not discontinue or modify any prescribed antiseizure drugs without consulting your doctor. Abrupt withdrawal can trigger breakthrough seizures, status epilepticus, or other serious complications.
Exclusion Criteria & Emergency Red Flags
- Sample Collection Exclusion: Active febrile illness, severe anaemia (Hb <7 g/dL), local infection at venipuncture site, inability to provide informed consent (parental/guardian consent required for minors per UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Test Exclusion: Refusal to complete mandatory pre‑test genetic counselling and pedigree documentation.
- Post‑Draw Red Flags: Prolonged bleeding, expanding haematoma, signs of anaphylaxis (swelling, wheezing, hypotension).
- Urgent Neurological Symptoms: New‑onset seizure clusters, status epilepticus, or severe adverse drug reactions – seek immediate emergency care.
Patient FAQ & Clinical Guidance
1. What does a DEPDC5 mutation mean for my epilepsy diagnosis?
DEPDC5 mutations disrupt mTOR signalling, causing familial focal epilepsy with variable seizure foci. A positive result confirms a genetic aetiology, helping tailor antiepileptic therapy, direct family screening, and avoid unnecessary investigations.
2. How is the DEPDC5 genetic test performed and what sample is needed?
The test requires a simple blood sample, extracted DNA, or one drop of blood on an FTA card. Our VIP home collection team uses cold‑chain logistics to preserve DNA integrity, and the sample is processed via NGS at our ISO‑certified laboratory.
3. Is pre‑test genetic counselling mandatory in the UAE?
Yes, a genetic counselling session is mandatory to construct a detailed pedigree chart of affected family members. This session, compliant with UAE Federal Decree‑Law No. 45 of 2021 (PDPL) and Federal Law No. 2 of 2019, ensures informed consent and accurate risk assessment.
UAE Regulatory & Data Privacy Adherence
✅ Data Protection & Health ICT Compliance
All personal data and genetic information are processed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow the provisions of Federal Decree‑Law No. 4 of 2016 on Medical Liability. DHA Facility License: 1143.
Clinical & Logistical Metadata
| Parameter | Details |
|---|---|
| Test Name | DEPDC5 Genetic Test for Familial Focal Epilepsy with Variable Foci (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood, Extracted DNA, or Dried Blood Spot (FTA card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene coding regions, exon‑intron boundaries, and CNV detection (≥200x coverage) |
| ICD-10-CM Code | G40.0 |
| LOINC Code | 96609-6 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians