Test Price
2,800 AED✅ Home Collection Available
DBH Gene (Dopamine Beta-Hydroxylase) Deficiency Genetic Test | DNA Labs UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee:
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing
Premium Logistics:
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — Available daily from 8 AM to 11 PM
Clinical Guidance:
Telephonic Post-Test Genetic Counseling by DHA-Licensed Medical Genetics Specialist
Insurance:
Direct Billing Verification via WhatsApp +971 54 548 8731
Corporate Laboratory:
DNA Labs UAE — DHA Facility License No. 1143
Accreditation:
ISO 9001:2015 Certified — Cert: INT/EGQ/2509DA/3139
Facility Address:
Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Test Overview & Methodology
The DBH Gene NGS Test is a comprehensive next-generation sequencing analysis targeting the entire coding region of the dopamine beta-hydroxylase gene. This test provides definitive genetic confirmation for individuals presenting with autonomic dysfunction, orthostatic hypotension, unexplained syncope, or exercise intolerance. By identifying pathogenic variants, copy-number alterations, and deep intronic mutations, this assay delivers superior diagnostic specificity compared to traditional biochemical catecholamine profiling methods.
| Feature | Our DBH NGS Test | Closest Alternative |
|---|---|---|
| Diagnostic Precision | 99.9% Sensitivity; identifies all pathogenic variants including deep intronic and copy-number changes | Biochemical catecholamine profiling (80–85% sensitivity, influenced by medication and diet) |
| Methodology | Next-Generation Sequencing (Illumina NovaSeq 6000) plus deletion/duplication analysis | High-pressure liquid chromatography (HPLC) measuring plasma norepinephrine/dopamine ratio |
| Turnaround Time | 21–28 Business Days with optional expedited reporting (contact lab for availability) | Variable; typically 14–28 days but requires multiple blood draws under controlled conditions |
| Sample Requirement | Single peripheral whole blood draw (EDTA) or FTA card finger-prick | Multiple timed blood draws with strict postural and dietary protocols |
Physician Insight & Safety Protocols
"A positive DBH variant does not automatically establish disease onset; it provides a risk profile that must be correlated with detailed autonomic function testing, plasma catecholamine levels, and comprehensive family history evaluation. This genetic test delivers maximum clinical value when ordered after specialist consultation rather than as an isolated screening measure. Proper pre-test counseling ensures patients understand the implications of both positive and negative results."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory
Important Pre-Test Considerations:
- Do not discontinue any prescribed medication (e.g., fludrocortisone, midodrine, beta-blockers) without explicit instruction from your treating physician.
- This test is not a substitute for ongoing clinical management or emergency medical care.
- Results should be interpreted by a qualified genetics professional in conjunction with a complete autonomic workup.
- Family member testing may be recommended following identification of a pathogenic variant.
Patient Safety Exclusion Criteria & Red Flags
- Not recommended for individuals with active febrile illness or severe coagulopathy without prior medical clearance.
- Minors must be accompanied by a legal guardian and present signed parental consent in accordance with UAE federal regulations.
- Do not schedule home collection if you experience new-onset chest pain, severe dizziness, or loss of consciousness — seek emergency medical care immediately.
- Patients with known anaphylaxis to latex or antiseptics must inform the phlebotomist before venipuncture.
Emergency Red Flag: If you experience sudden palpitations, fainting, or breathing difficulty while preparing for sample collection, call 998 for ambulance services without delay.
Patient FAQ & Clinical Guidance
1. What is DBH deficiency and who should consider this genetic test?
Dopamine beta-hydroxylase deficiency is a rare autosomal recessive disorder that impairs conversion of dopamine to norepinephrine, leading to severe orthostatic hypotension, ptosis, and autonomic dysfunction. This test is recommended for individuals with unexplained fainting episodes, low blood pressure upon standing, exercise intolerance, chronic fatigue, or a family history of sudden cardiac events despite normal cardiac workup.
2. How is the sample collected and can I use a home service?
We offer VIP mobile phlebotomy with ISO-certified cold-chain transport. A single peripheral whole blood draw into an EDTA tube or an FTA card finger-prick sample is collected in your home between 8 AM and 11 PM daily. The temperature-controlled chain of custody ensures complete DNA stability from collection to laboratory processing.
3. How is my genetic data protected and will insurance cover this test?
All genetic data is handled exclusively under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your results are never shared without explicit written consent. Direct billing verification with your insurance provider is conducted via WhatsApp before booking. Contact our billing team at +971 54 548 8731 to confirm coverage.
UAE Regulatory & Data Privacy Adherence
Data Protection Framework:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
Clinical Safety & Consent:
- Federal Decree-Law No. 4 of 2016 on Medical Liability
- DHA Standard for Genetic Testing and Counseling Services
Corporate Entity: DNA Labs UAE | DHA Facility License No. 1143
Accreditation: ISO 9001:2015 — Cert: INT/EGQ/2509DA/3139
Clinical Governance: All genetic tests are reviewed and authorized by our Consultant Medical Genetics specialist prior to result release.
Clinical & Logistical Metadata
| Test Name | DBH Gene (Dopamine Beta-Hydroxylase) Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina NovaSeq 6000 with deletion/duplication analysis |
| ICD-10-CM Code | E70.8 |
| LOINC Code | 94086-1 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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