Test Price
2,800 AED✅ Home Collection Available
CUBN Gene Megaloblastic Anemia Type 1 (Finnish Type) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
✓ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (available daily 8 AM to 11 PM).
✓ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed specialists.
✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CUBN Gene Megaloblastic Anemia Type 1 (Finnish Type) NGS Test sequences the entire coding region of the cubilin gene to detect pathogenic variants responsible for Imerslund-Gräsbeck syndrome, a rare autosomal recessive disorder causing selective vitamin B12 malabsorption. Performed on Whole Blood (EDTA), Extracted DNA or Dried Blood Spot (FTA Card) via Next-Generation Sequencing (NGS), it delivers definitive diagnosis, carrier status, and familial risk assessment with a turnaround of 3–4 weeks.
| Feature | Our DHA-Certified Test | Closest Alternative |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – full gene coverage with CNV detection | Sanger sequencing – limited to known mutations only |
| Turnaround Time | 3–4 weeks | 5–8 weeks |
| Variant Detection | SNVs, indels, copy number variants (CNVs) | Pre‑specified missense mutations only |
| Regulatory Backing | UAE PDPL, Federal Law No. 2 of 2019, ISO 9001:2015 | Non‑local lab; uncertain data privacy compliance |
Physician Insight & Safety Protocols
“A DNA result is a critical piece of the clinical puzzle; it must be interpreted in concert with hematologic indices and family history. As your DHA-licensed consultant in medical genetics, I ensure that no treatment decision is made on genetic data alone without a thorough consultation.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Card
⚠️ Medication Warning: Do not discontinue any prescribed medication without consulting your doctor. A genetic test is not a substitute for clinical management.
Exclusion Criteria & Emergency Red Flags
- Not indicated for acute hemolytic crisis or active bleeding; seek emergency care immediately.
- Do not delay life‑saving parenteral vitamin B12 therapy if severe macrocytic anemia with neurological signs is present.
- Mandatory pre‑test genetic counseling for minors; parental consent required under Federal Law No. 2 of 2019.
- Contact your physician urgently if you experience severe fatigue, shortness of breath, confusion, or palpitations.
Patient FAQ & Clinical Guidance
1. What makes this test superior to a standard vitamin B12 blood measurement?
This provides the definitive genetic aetiology of megaloblastic anemia by directly identifying pathogenic mutations in the CUBN gene — standard serum B12 assays cannot distinguish a genetic defect in cubilin‑mediated absorption from dietary deficiency.
2. Can this test be performed on children?
Yes, the CUBN gene test can be performed on children after genetic counseling and parental consent as per Federal Law No. 2 of 2019. A simple blood sample is collected through our VIP home collection service.
3. How are results reported and what happens if a variant of uncertain significance (VUS) is found?
Results are delivered in 3–4 weeks with a detailed clinical report. If a VUS is identified, our DHA-licensed genetic counselors provide a teleconsultation to explain its implications and recommend follow‑up family studies or functional testing.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is ISO 9001:2015 certified (Certification No. INT/EGQ/2509DA/3139). All medical advice is provided by DHA-licensed professionals.
Clinical & Logistical Metadata
| Test Name | CUBN Gene Megaloblastic Anemia Type 1 (Finnish Type) Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV detection |
| ICD-10-CM Code | D51.1 |
| LOINC Code | 94122-7 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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