Test Price
2,800 AED✅ Home Collection Available
CTLA4 Gene Sequencing Test for Autoimmune Lymphoproliferative Syndrome Type 5 in Dubai | 2,800 AED
Executive Summary & Core Metrics
This advanced genetic test provides definitive molecular diagnosis for autoimmune lymphoproliferative syndrome type 5 (ALPS5) caused by pathogenic CTLA4 gene variants, delivered under the supervision of a Consultant Medical Geneticist at DNA Labs UAE.
- ✔ Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited whole-gene Next Generation Sequencing.
- ✔ Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- ✔ Clinical Guidance: Telephonic post-test clinical guidance for result interpretation by a specialist geneticist.
- ✔ Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The CTLA4 genetic test detects pathogenic variants in the CTLA4 gene associated with autoimmune lymphoproliferative syndrome type 5 (ALPS5) and related immunodysregulation syndromes. This advanced whole-gene sequencing approach offers definitive molecular diagnosis to guide personalized treatment strategies, including immunomodulatory therapy and hematopoietic stem cell transplantation evaluation.
| Feature | Premium NGS Test | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing with 99.9% sensitivity for all variant types (SNVs, indels, CNVs) | Targeted panel or Sanger sequencing of limited exons |
| Methodology | Next Generation Sequencing (NGS) with clinically validated bioinformatics pipeline | Sanger sequencing or single-gene testing |
| Turnaround Speed | 3 to 4 Weeks with comprehensive clinical report | 4 to 6 weeks, may require additional reflex testing |
Physician Insight & Safety Protocols
“A molecular diagnosis of CTLA4 haploinsufficiency can fundamentally reshape clinical management, but genetic results must always be correlated with immunological phenotype and family pedigree analysis. I recommend all patients pursue pre-test and post-test genetic counselling to fully understand the implications for themselves and their biological relatives.”
Advisory: Medication Safety
Patients currently prescribed immunosuppressive therapy (including corticosteroids, mycophenolate, or biologic agents) must not alter or discontinue their medication regimen based on test results alone. Any treatment modification requires direct supervision by the managing immunologist or hematologist. Contact your physician before making any changes.
Safety Exclusion & ER Red Flags
- Exclusion Criteria: Patients medically unstable for venipuncture; active severe infection requiring inpatient care; inability to provide informed consent; known bleeding diathesis contraindicating blood draw.
- ER Red Flags: Unexplained high-grade fever unresponsive to antipyretics, rapid-onset splenomegaly with abdominal pain, new cytopenias (hemoglobin < 8 g/dL, platelets < 50,000), or neurological deterioration — seek immediate emergency care at the nearest hospital.
Patient FAQ & Clinical Guidance
1. What is the purpose of the CTLA4 genetic test?
A: This test identifies pathogenic mutations in the CTLA4 gene that cause autoimmune lymphoproliferative syndrome type 5 (ALPS5). The result guides definitive diagnosis, informs family screening, and directs targeted therapies such as abatacept or hematopoietic stem cell transplantation.
2. How should I prepare for this genetic test?
A: You must provide a detailed personal and family history of autoimmune or lymphoproliferative conditions. Pre-test genetic counselling is strongly recommended to review inheritance patterns, draw a three-generation pedigree, and discuss the potential for incidental findings. No fasting is required for the blood draw.
3. How long do results take and how will I receive them?
A: Results are delivered within 3 to 4 Weeks via a secure electronic PDF report. The report includes variant classification per ACMG guidelines, clinical interpretation, and therapeutic recommendations. Optional telephonic post-test clinical guidance with the reporting geneticist is available upon request.
4. Can this test detect carriers in my family?
A: Yes. CTLA4 deficiency follows an autosomal dominant inheritance pattern with variable penetrance. Targeted familial variant testing can be arranged for first-degree relatives following identification of a pathogenic variant in the index patient. Contact DNA Labs UAE for coordination of family cascade testing.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA) and adheres to all applicable federal data protection and health information security laws. Patient genetic data is processed and stored in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing and patient consent procedures conform to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and follows CAP-accredited quality standards for molecular diagnostics.
Clinical & Logistical Metadata
| Test Name | CTLA4 Gene Sequencing (Autoimmune Lymphoproliferative Syndrome, Type 5) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) |
| Methodology Used | Next Generation Sequencing (NGS) — Whole Gene Sequencing with CNV detection |
| ICD-10-CM Code | D89.82 |
| LOINC Code | 82175-0 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA Facility License No: 1143 |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians