Test Price
2,800 AEDโ Home Collection Available
CRYBB1 Gene Cataract Type 17 Genetic Testing in Dubai | 2,800 AED | Accurate Diagnosis
Executive Summary & Core Metrics
โ Diagnostic Precision: 99.9% analytical sensitivity for CRYBB1 pathogenic variants via ISO 15189-accredited NGS.
โ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, 8 AMโ11 PM daily.
โ Clinical Guidance: Complimentary post-test telephonic counseling with a consultant medical geneticist to explain your results.
โ Insurance & Billing: Direct verification via WhatsApp at +971 54 548 8731 before your draw.
Test Overview & Methodology
The CRYBB1 gene encodes beta-crystallin B1, a major structural lens protein. Pathogenic variants cause congenital or early-onset cataract type 17 and other lens anomalies, often inherited in an autosomal dominant pattern. Our NGS test sequences all coding exons and splice sites, enabling precise molecular diagnosis and family risk stratification.
| Feature | Our NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Methodology | Next-Generation Sequencing (all exons + flanking intronic regions) | Targeted PCR + Sanger (1โ2 exons only) |
| Variant Detection | SNVs, indels, copy number changes (via coverage analysis) | SNVs and small indels only |
| Turnaround | 3โ4 Weeks | 6โ8 Weeks |
| Price | 2,800 AED | 3,500+ AED (dependent on exon count) |
Physician Insight & Safety Protocols
โCRYBB1โassociated cataract exhibits variable expressivity; a negative NGS result does not exclude a different genetic etiology. This test must be interpreted in conjunction with detailed ophthalmic phenotyping, family history, and pedigree analysis. Surgical planning remains under the care of your ophthalmologist.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403
Important Medication Advisory
Do not discontinue, adjust, or change any prescribed medication (including eye drops, anticoagulants, or systemic therapy) without consulting your treating physician. Blood-thinning medications must be disclosed before sample collection to avoid bleeding complications.
Safety Precautions and Contraindications
- Active conjunctival or periocular infection โ postpone collection.
- Severe needle phobia with history of vasovagal syncope โ require supervised medical setting.
- Children under 18: legal guardian consent required as per Federal Law No. 2 of 2019; pediatric phlebotomist recommended.
- If you experience sudden vision loss, acute eye pain, or signs of retinal detachment, seek emergency ophthalmic care immediately โ genetic testing is not for acute emergency diagnosis.
- Patients on dual antiplatelet therapy or warfarin with INR > 3.0 require medical clearance before blood draw.
Patient FAQ & Clinical Guidance
1. What does the CRYBB1 gene test detect, and can it predict cataract severity?
This NGS test identifies pathogenic variants in all coding regions of the CRYBB1 gene, directly confirming a genetic cause of multiple types of cataract type 17 and enabling accurate risk stratification for family members based on specific mutation type.
2. How is the sample collected, and what preparations are required?
Our licensed phlebotomist collects a small blood sample (or a single drop on an FTA card) during a home visit; no fasting is needed, but you must provide a complete clinical history and pedigree chart as pre-test information for accurate genomic interpretation.
3. Is this test covered by UAE health insurance?
Many UAE insurers cover medically indicated genetic testing; our team verifies your benefits directly via WhatsApp (+971 54 548 8731) before scheduling, ensuring compliance with UAE PDPL data privacy requirements.
UAE Regulatory & Data Privacy Adherence
This test is performed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted and stored on sovereign servers within the UAE. The laboratory operates under DHA Facility License 1143 and holds ISO 9001:2015 certification (INT/EGQ/2509DA/3139).
For 24/7 support: WhatsApp +971 54 548 8731 | Home collection available throughout Dubai, Abu Dhabi, Sharjah, and Northern Emirates.
Clinical & Logistical Metadata
| Test Name | CRYBB1 Gene (Cataract Type 17) โ NGS Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3 mL in EDTA tube) or FTA Card |
| Methodology Used | Next-Generation Sequencing (whole gene coding regions + splice sites) |
| ICD-10-CM Code | Q12.0, H26.9 |
| LOINC Code | 82709-1 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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