Test Price
2,800 AED✅ Home Collection Available
CRLF1 Gene Cold-Induced Sweating Syndrome (CISS) Genetic Test in UAE
Executive Summary & Core Metrics
This diagnostic assay provides molecular confirmation of CRLF1-related Cold-Induced Sweating Syndrome via comprehensive next-generation sequencing. The test is designed for pediatricians, neonatologists, and clinical geneticists evaluating patients with paradoxical cold-induced sweating, dysmorphic features, and congenital contractures.
- Diagnostic Accuracy: 99.9% analytic sensitivity and specificity via ISO-accredited NGS pipeline.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM to 11 PM).
- Clinical Guidance: Post-test telephonic consultation for result interpretation and family planning.
- Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
- Price: 2,800 AED inclusive of genetic counseling, sequencing, and clinical reporting.
Test Overview & Methodology
The CRLF1 Gene Cold-Induced Sweating Syndrome (CISS) test employs next-generation sequencing to interrogate the entire coding region and splice sites of the CRLF1 gene. Pathogenic variants in this gene cause an autosomal recessive disorder characterized by profuse sweating upon exposure to cool temperatures, distinctive craniofacial dysmorphism, and progressive joint contractures. Early molecular diagnosis enables targeted management, thermoregulatory counseling, and recurrence risk assessment for families.
Pre-Test Preparation: A detailed clinical history documenting cold-induced sweating episodes, dysmorphic features, and family pedigree is required. Genetic counseling is mandatory prior to sample collection. No fasting or medication restriction is needed unless specified by your referring physician.
| Feature | Our Test (NGS+) | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) with full gene coverage | Sanger sequencing limited to known hotspots |
| Precision | >99.9% analytic sensitivity & specificity | ~99% for targeted regions; may miss novel variants |
| Turnaround Time | 3–4 weeks | 4–6 weeks with sequential testing |
Physician Insight & Safety Protocols
"Comprehensive NGS analysis of the CRLF1 gene provides definitive molecular confirmation for Cold-Induced Sweating Syndrome. Identifying biallelic pathogenic variants clarifies the genetic etiology, enables accurate recurrence risk counseling, and guides thermoregulatory management strategies. This test is indicated for individuals presenting with the classic triad of cold-triggered sweating, facial dysmorphism, and congenital contractures."
Pre-Test Clinical Advisory
Do not discontinue any prescribed medication without consulting your doctor. This genetic test does not replace ongoing clinical management. A mandatory genetic counseling session must be completed before sample collection to document family pedigree, discuss inheritance patterns, and obtain informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Safety Exclusion Criteria & Clinical Red Flags
- Not indicated for asymptomatic individuals lacking clinical suspicion of CRLF1-related syndrome or without prior genetic counseling.
- Neonates with severe thrombocytopenia or bleeding diathesis should not undergo venipuncture; consider dried blood spot collection after physician approval.
- If you experience excessive bleeding, hematoma, or signs of infection at the sample collection site, seek immediate medical attention.
- Patients with acute febrile illness should postpone blood draw to ensure sample integrity and patient safety.
Patient FAQ & Clinical Guidance
1. What is the CRLF1 gene test used for?
This test detects pathogenic variants in the CRLF1 gene to confirm a diagnosis of Cold-Induced Sweating Syndrome (CISS), a rare autosomal recessive disorder. It helps differentiate CISS from other conditions with similar presentations and enables accurate family counseling.
2. How long does it take to receive CRLF1 NGS test results?
Results are typically available within 3 to 4 weeks from sample receipt, ensuring comprehensive NGS analysis and thorough variant classification according to ACMG guidelines.
3. What sample types are accepted for this genetic test?
Accepted specimens include whole blood collected in an EDTA tube, extracted DNA of sufficient quality, or a single drop of blood on an FTA card. Our VIP Mobile Phlebotomy service is available daily from 8 AM to 11 PM for home collection.
4. Is genetic counseling required before testing?
Yes, a genetic counseling session is mandatory to construct a family pedigree, discuss the implications of possible CRLF1 variants, and ensure informed consent is obtained in compliance with UAE medical liability regulations.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
All genetic analyses are performed in our ISO 9001:2015 certified laboratory (Cert: INT/EGQ/2509DA/3139). Genomic variants are classified per current ACMG guidelines. Results are interpreted and reported by DHA-licensed physicians. Patient confidentiality and data security are maintained throughout the testing lifecycle.
Clinical & Logistical Metadata
| Test Name | CRLF1 Gene Cold-Induced Sweating Syndrome (CISS) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole blood (EDTA tube), extracted DNA, or FTA card (dried blood spot). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM–11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) with full coding region and splice-site coverage |
| ICD-10-CM Code | Q87.8, Z13.79, Z15.09 |
| LOINC Code | 81247-7 |
| DHA Facility License & Address | Facility License No. 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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