Test Price
2,800 AED✅ Home Collection Available
COX10 Gene Genetic Test for Mitochondrial Encephalopathy with Proximal Renal Tubulopathy in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance for result interpretation by a specialist team.
- Insurance Made Easy: Direct Billing Verification – send your policy copy via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This Next‑Generation Sequencing (NGS) test analyzes the entire coding region of the COX10 gene to identify pathogenic variants responsible for mitochondrial encephalopathy with proximal renal tubulopathy (cytochrome c oxidase deficiency). The test is designed for patients with neurological and renal symptoms suggestive of this rare disorder and delivers clinically actionable results in 3 to 4 weeks.
| Feature | Our COX10 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision / Coverage | Full gene with intron‑exon boundaries, high read depth, CNV detection | Only exons; can miss large deletions and deep intronic variants |
| Methodology | NGS on Illumina platform + Sanger confirmation of pathogenic calls | Sanger sequencing – limited scalability |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Price | 2800 AED | ~3500 AED* |
Physician Insight & Safety Protocols
“This test is a powerful diagnostic tool; however, a negative result does not exclude mitochondrial disease. All genetic findings must be interpreted in correlation with clinical and biochemical data. I strongly advise a consultation with a neurologist and genetic counselor before and after testing to fully understand the implications for the patient and family.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403)
Advisory – Medication & Pre-Test Precautions
Do not discontinue prescribed medication without consulting your doctor.
If you are taking anticoagulants, inform your physician before the blood collection appointment.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active systemic infection or coagulation disorder that could compromise sample integrity; test not indicated for asymptomatic individuals without family history or clinical suspicion.
- Emergency Red Flags – Seek immediate medical care if you experience: sudden loss of consciousness, uncontrolled seizures, acute confusion, severe flank pain with reduced urine output, or signs of acute kidney injury.
- This genetic test is not a substitute for emergency care; always prioritise urgent medical management.
Patient FAQ & Clinical Guidance
1. What does the COX10 Genetic Test detect?
This test detects pathogenic variants in the COX10 gene that cause mitochondrial encephalopathy and proximal renal tubulopathy. It analyses the full gene sequence using high‑coverage NGS, identifying single nucleotide changes, small insertions/deletions, and copy number alterations. Results help confirm a clinical diagnosis and guide family screening.
2. How is the sample collected and what preparation is needed?
A simple blood draw (whole blood) is collected by a qualified phlebotomist, strictly following cold‑chain protocols. A pre‑test genetic counselling session is mandatory to draw a pedigree chart and review family history. Fasting is not required; however, inform the team of all medications, especially anticoagulants, before the appointment.
3. How long does it take to receive results and who interprets them?
Results are typically ready in 3 to 4 weeks and are interpreted by a multidisciplinary team including neurologists, nephrologists, and medical geneticists. A post‑telephonic consultation is included to explain the clinical significance and recommend next steps for the patient and at‑risk family members.
UAE Regulatory & Data Privacy Adherence
Full UAE Compliance: This test is performed under DHA Facility License 1143 (Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE). Data protection adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety and consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | COX10 Gene Genetic Test for Mitochondrial Encephalopathy with Proximal Renal Tubulopathy |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) |
| Methodology Used | Next-Generation Sequencing (NGS) + Sanger Confirmation |
| ICD-10-CM Code | G31.81 (Mitochondrial encephalopathy), N19 (Unspecified kidney failure) |
| LOINC Code | 93353-6 (COX10 gene mutation analysis) |
| DHA Facility License & Laboratory Address | License: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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