Test Price
1,800 AED✅ Home Collection Available
Connexin 26 Mutation Detection Test in UAE | 1,800 AED | DHA Licensed Lab
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity via ISO-accredited PCR + bidirectional Sanger sequencing.
- Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM – 11 PM.
- Post-Test Support: Complimentary telephone consultation with a qualified genetic counselor after results.
- Insurance: Direct pre-authorization check via WhatsApp +971 54 548 731.
Test Overview & Methodology
This genetic test screens for pathogenic variants in the GJB2 gene encoding Connexin 26 protein – the most common hereditary cause of congenital sensorineural hearing loss. It utilises PCR amplification followed by bidirectional Sanger sequencing to deliver definitive molecular diagnosis. The assay is validated for early detection in newborns, children, and adults, supporting timely intervention and family planning.
| Feature | Our Connexin 26 Test | Closest Alternative |
|---|---|---|
| Methodology | PCR + Bidirectional Sanger Sequencing | PCR only / Non‑sequencing |
| Turnaround Time | 13 working days (sample by 11 am Saturday) | 21–28 working days |
| Diagnostic Sensitivity | 99.9% (ISO‑accredited lab) | ~95% (variable) |
| Price (AED) | 1,800 | 2,500+ |
Physician Insight & Safety Protocols
"As a clinical geneticist, I understand that waiting for hereditary hearing loss results can be emotionally challenging. Connexin 26 analysis must always be interpreted alongside comprehensive audiometry and family history to guide precise management. Our team is committed to supporting you at every stage."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory & Exclusion Criteria
Important Safety Notice
- Exclusion: This test is not intended for emergency diagnosis or acute management. Do not use during active febrile illness as sample integrity may be compromised.
- Red Flags: Sudden hearing loss, acute vertigo, facial weakness, or new neurological deficits require immediate emergency care.
- Mandatory Document: A completed Genomics Clinical Information Requisition Form (Form 20) must be provided prior to collection.
Patient FAQ & Clinical Guidance
1. What exactly does the Connexin 26 mutation test detect?
Connexin 26 mutation testing identifies GJB2 gene variants that are the leading genetic cause of congenital sensorineural hearing loss and associated auditory‑neuropathy spectrum disorders. It provides molecular confirmation essential for clinical diagnosis and prognostication.
2. How is the sample collected and processed?
A 4 mL whole blood sample is drawn into a lavender‑top EDTA tube. It is shipped under refrigerated conditions to our laboratory, where it undergoes PCR amplification followed by bidirectional Sanger sequencing. Samples arriving by Saturday 11 am are processed with a guaranteed 13‑working‑day turnaround.
3. When will I receive my results?
Results are delivered within 13 working days from the sample arrival time (cut‑off Saturday 11 am). Expedited reporting is not available due to the complexity of bidirectional sequencing and thorough variant interpretation.
4. Can this test be performed during pregnancy?
The Connexin 26 test can be offered to expectant parents for carrier screening or prenatal diagnosis (in conjunction with chorionic villus sampling or amniocentesis). A genetic counselor will discuss the implications and limitations before proceeding.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This laboratory service operates in full accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 concerning the use of information and communication technology in health fields. All clinical testing and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and holds DHA facility license #1143.
Clinical & Logistical Metadata
| Test Name | Connexin 26 (GJB2) Mutation Detection |
| Price (AED) | 1,800 |
| Turnaround Time | 13 working days (sample by 11 am Saturday) |
| Sample Type / Matrix | Whole blood (4 mL lavender‑top EDTA tube) – VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection available daily 8 AM – 11 PM |
| Methodology Used | PCR amplification + Bidirectional Sanger Sequencing |
| ICD-10-CM Code | H90.3 (Sensorineural hearing loss, bilateral) |
| LOINC Code | 21679-8 (GJB2 gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Laboratory Address | DHA License #1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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