Test Price
2,800 AEDโ Home Collection Available
CISD2 Gene (Wolfram Syndrome Type 2) Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
DIAGNOSTIC PRECISION Accuracy: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing.
Price: 2,800 AED โ All-inclusive (no hidden fees).
Turnaround Time: 21โ28 calendar days from sample accession.
Logistics: VIP Mobile Phlebotomy & temperature-controlled cold-chain home collection daily 8 AM โ 11 PM.
Post-Test Support: Telephonic clinical interpretation with board-certified genetic counsellors.
Insurance: Direct Billing Verification via WhatsApp +971545488731.
Laboratory: DNA Labs UAE | DHA Facility License No. 1143.
Test Overview & Methodology
The CISD2 gene NGS test analyzes the entire coding region and splice sites for pathogenic variants linked to Wolfram syndrome type 2 (WFS2) โ a rare autosomal recessive disorder characterized by juvenile-onset diabetes mellitus, progressive optic atrophy, sensorineural hearing loss, and neurological complications. This definitive molecular diagnosis enables early intervention, family cascade screening, and tailored management.
Methodology: Next-Generation Sequencing (NGS) with Sanger confirmation for all reported variants. Bioinformatics pipeline includes alignment to GRCh38, variant calling with >99.9% sensitivity, and classification per ACMG/AMP guidelines.
Comparison: NGS vs. Sanger Sequencing
| Feature | Our Test (NGS) | Single-Gene Sanger |
|---|---|---|
| Precision | 99.9% | ~97% (limited by target size) |
| Turnaround | 3โ4 weeks | 6โ8 weeks |
| Coverage | Full gene + intronic flanks | Select exons only |
| Cost Efficiency | 2,800 AED (comprehensive) | Variable, often higher per exon |
Physician Insight & Safety Protocols
โGenetic testing for CISD2-related Wolfram syndrome type 2 requires careful interpretation within full clinical and family context. A positive result must trigger multidisciplinary evaluation including endocrinology, ophthalmology, and audiology. Pre-test genetic counselling is mandatory to address potential psychological impact and implications for family members. Never alter or discontinue prescribed medications without direct medical supervision.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory: Medication & Safety
Do not discontinue prescribed medications without consulting your physician.
Any changes to medication should be made only under the guidance of the treating specialist. The genetic test result itself does not replace ongoing medical management.
Exclusion Criteria
- Acute febrile illness at the time of sample collection.
- Lack of informed consent from patient or legal guardian (mandatory for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Individuals who have not received pre-test genetic counselling to discuss potential psychological impact and implications.
This test does not replace urgent medical evaluation for acute symptoms.
Patient FAQ & Clinical Guidance
1. What is the CISD2 gene test and why is it performed?
The CISD2 gene test uses next-generation sequencing to detect disease-causing mutations in the CISD2 gene, responsible for Wolfram syndrome type 2. This condition presents with early-onset diabetes, optic atrophy, hearing loss, and neurological deterioration. The test confirms diagnosis, guides management, and enables family screening.
2. How long does it take to receive results?
Results are delivered within 21 to 28 calendar days from sample accession, following ISO-compliant NGS processing, bioinformatics analysis, and clinical variant interpretation.
3. Is home sample collection available across the UAE?
Yes, our certified phlebotomists provide VIP mobile phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM, covering all emirates. Sample integrity is maintained throughout transport.
4. What should I do if the test result is positive?
A positive result indicates a pathogenic variant in CISD2. Our genetic counsellor will arrange a telephonic consultation to explain the result and recommend referrals to relevant specialists (endocrinology, ophthalmology, audiology, neurology). Family cascade testing is advised.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic data is handled in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent, data anonymization, and secure storage are enforced at every stage.
Medical Liability & Consent: Clinical testing and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring ethical and legal standards are met. Pre-test counselling is mandatory for all genetic tests.
DHA Oversight: DNA Labs UAE operates under DHA Facility License No. 1143, with regular audits to maintain compliance with Dubai Healthcare City regulations and international quality standards.
Clinical & Logistical Metadata
| Test Name | CISD2 Gene (Wolfram Syndrome Type 2) NGS Analysis |
| Price (AED) | 2,800 AED (all-inclusive) |
| Turnaround Time | 21โ28 calendar days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation; Variant interpretation per ACMG/AMP guidelines |
| ICD-10-CM Code | E13.8 (Diabetes mellitus due to genetic defect of beta-cell function โ Wolfram syndrome) |
| LOINC Code | 82939-0 (CISD2 gene mutation analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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