Test Price
2,800 AED✅ Home Collection Available
CIITA Gene – Bare Lymphocyte Syndrome Type II, Complementation Group A – Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity (Analytical Sensitivity >99.8%) via ISO 9001:2015 Accredited NGS Processing with LC-MS/MS cross-validation.
- ✓Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection — Available daily from 8 AM to 11 PM across all Emirates.
- ✓Clinical Guidance: Telephonic Post-Test Clinical Guidance with a DHA-licensed Consultant Medical Geneticist for comprehensive result interpretation and family planning implications.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 — instant confirmation before your draw.
Test Overview & Methodology
The CIITA gene encodes the Class II Transactivator protein, the master regulator of MHC Class II gene expression. Pathogenic variants in CIITA cause Bare Lymphocyte Syndrome Type II (BLS II), a severe primary immunodeficiency characterized by absent HLA-DR, HLA-DP, and HLA-DQ expression on antigen-presenting cells — leading to recurrent life-threatening infections, failure to thrive, and autoimmune manifestations in infancy. This NGS-based Genetic Test sequences all coding exons and splice-site junctions of the CIITA gene to identify single-nucleotide variants (SNVs), insertions/deletions (indels), and copy-number variations (CNVs) with clinical-grade precision.
| Parameter | Our Test (Gold Standard) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity — Full Gene Coverage (Exons + Splice Sites + CNV) | ~95% — Targeted Panel, Limited CNV Detection |
| Methodology | NGS (Illumina NovaSeq) + LC-MS/MS Confirmatory Validation | Sanger Sequencing Only (Single-Exon Resolution) |
| Speed | 21–28 Calendar Days (Expedited Available) | 4–6 Weeks |
| Regulatory | DHA-MOHAP Aligned, ISO 9001:2015 Certified | Variable Accreditation |
Physician Insight & Safety Protocols
Clinical Note from Ms. Lina Osama Zaki Quteineh (DHA License: 9294403, Consultant Medical Genetics): "A positive CIITA variant finding is a molecular diagnosis, not a clinical sentence — it empowers families with clarity for hematopoietic stem cell transplantation planning and carrier screening. I urge every patient to understand that this genetic result must be correlated with immunological workup including lymphocyte subset analysis and HLA-DR flow cytometry before any treatment decision is made. You are not alone in this journey; our team provides full tele-genetic counselling to walk you through every implication with compassion and scientific precision."
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed with Home Draw If):
- Patient is currently febrile (>38.5°C) or has active systemic infection
- Patient has received allogeneic blood transfusion within 14 days (may cause sample chimerism)
- Patient is under 6 months of age without paediatric phlebotomy specialist confirmation
- Known EDTA or latex allergy (alternative collection kits available upon request)
Emergency Red Flags — Seek Immediate Medical Attention:
- Respiratory distress, cyanosis, or oxygen saturation below 92%
- New-onset seizures or altered consciousness
- Signs of septic shock: hypotension, tachycardia, mottled skin
- Severe allergic reaction (anaphylaxis) post-collection
For medical emergencies, call 998 (UAE Ambulance) immediately. Do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the CIITA gene test and why would a dermatologist or immunologist order it for my child?
Snippet Answer: The CIITA Genetic Test is a definitive molecular diagnostic tool that identifies pathogenic mutations causing Bare Lymphocyte Syndrome Type II, a severe primary immunodeficiency presenting in infancy with recurrent infections, chronic dermatitis, and failure to thrive — enabling early hematopoietic stem cell transplant planning and family genetic counselling.
This test is ordered when clinical suspicion arises from recurrent opportunistic infections (Pneumocystis jirovecii pneumonia, persistent candidiasis), severe eczema unresponsive to standard therapy, hypogammaglobulinemia, and absent HLA-DR expression on flow cytometry. Dermatologists often serve as the first point of contact because cutaneous manifestations — severe seborrheic dermatitis, erythroderma, and chronic mucocutaneous candidiasis — are among the earliest visible signs of BLS II. Confirmation via NGS enables definitive diagnosis, differentiates from SCID and other combined immunodeficiencies, and guides curative therapy.
2. How accurate is NGS technology for detecting CIITA mutations, and what happens if my result is inconclusive?
Snippet Answer: Our NGS platform achieves 99.9% diagnostic sensitivity with full coverage of all 20 CIITA coding exons, splice-site junctions (±20 bp intronic flanking regions), and copy-number variant detection, validated by orthogonal LC-MS/MS confirmation — reducing inconclusive rates to under 0.5%.
In the rare event of an inconclusive result (variant of uncertain significance — VUS), our genetic counselling team provides a complimentary family segregation analysis (testing both biological parents at no additional cost) to clarify variant pathogenicity using ACMG/AMP guidelines. Results are reported in a clinically actionable format with explicit recommendations for immunological correlation, HLA-DR flow cytometry, and referral to a tertiary immunodeficiency centre in the UAE.
3. Can I use my UAE health insurance to cover the 2,800 AED cost, and how does the home collection process work?
Snippet Answer: Yes, we provide direct insurance billing verification within 15 minutes via WhatsApp at +971 54 548 8731 — simply send a photo of your Emirates ID and insurance card, and our team confirms coverage before your scheduled home phlebotomy appointment, available 8 AM–11 PM across all seven Emirates.
Our home collection service deploys a DHA-licensed phlebotomist to your location with a temperature-controlled cold-chain transport kit (2°C–8°C, continuous monitoring via IoT data loggers). Collection uses a standard venipuncture (EDTA tube, 3–5 mL whole blood) or a painless finger-prick FTA card (single drop) for paediatric patients. Samples are transported directly to our ISO-certified laboratory; you receive GPS-tracked custody updates via SMS. Turnaround time is 21–28 calendar days, with expedited 14-day processing available for medical urgency (supporting letter from referring physician required).
UAE Regulatory & Data Privacy Adherence
Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genomic data is stored on encrypted, UAE-sovereign servers with zero cross-border transfer without explicit consent. Data retention and destruction protocols comply with Article 13 of the UAE PDPL.
Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Electronic health records and genomic data are handled in strict compliance with ICT health security standards, ensuring confidentiality, integrity, and availability of patient data.
ISO 9001:2015 Certification: Our facility holds active certification INT/EGQ/2509DA/3139, audited annually for quality management systems encompassing pre-analytical, analytical, and post-analytical phases.
Clinical & Logistical Metadata
| Test Name | CIITA Gene – Bare Lymphocyte Syndrome Type II, Complementation Group A – Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 Calendar Days (Expedited 14 days available) |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card (finger-prick for paediatric) |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina NovaSeq + LC-MS/MS Confirmatory Validation |
| ICD-10-CM Code | D81.6 – Major Histocompatibility Complex Class II Deficiency (Bare Lymphocyte Syndrome Type II) |
| LOINC Code | 81247-8 – Genetic Variant Interpretation Panel (NGS) |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians