Test Price
2,800 AED✅ Home Collection Available
CIITA Gene – Bare Lymphocyte Syndrome Type II, Complementation Group A – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CIITA لمتلازمة الخلايا الليمفاوية العارية النوع الثاني، مجموعة التكملة أ في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary — Clinical Excellence, Delivered to Your Door
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity (Analytical Sensitivity >99.8%) via ISO 9001:2015 Accredited NGS Processing with LC-MS/MS cross-validation.
- ✓Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy — 8 AM to 11 PM, 7 days a week across all Emirates.
- ✓Clinical Guidance: Telephonic Post-Test Clinical Guidance with a DHA-licensed molecular geneticist for comprehensive result interpretation and family planning implications.
- ✓Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 — instant confirmation before your draw.
الملخص التنفيذي
يُعد تحليل تسلسل الجيل التالي (NGS) لجين CIITA فحصاً جينياً متطوراً يكشف عن الطفرات المسببة لمتلازمة الخلايا الليمفاوية العارية النوع الثاني (عوز معقد التوافق النسيجي الرئيسي من الدرجة الثانية)، وهو اضطراب مناعي وراثي نادر يظهر في الطفولة المبكرة. نقدم هذا الفحص بدقة تشخيصية تبلغ 99.9% عبر مختبرات معتمدة وفق معيار ISO 9001:2015، مع خدمة سحب الدم المنزلي المبرد والاستشارة الوراثية المتخصصة عن بُعد من أطباء مرخصين من هيئة الصحة بدبي.
Overview — What This Test Reveals
The CIITA gene encodes the Class II Transactivator protein, the master regulator of MHC Class II gene expression. Pathogenic variants in CIITA cause Bare Lymphocyte Syndrome Type II (BLS II), a severe primary immunodeficiency characterized by absent HLA-DR, HLA-DP, and HLA-DQ expression on antigen-presenting cells — leading to recurrent life-threatening infections, failure to thrive, and autoimmune manifestations in infancy. This NGS-based Genetic Test sequences all coding exons and splice-site junctions of the CIITA gene to identify single-nucleotide variants (SNVs), insertions/deletions (indels), and copy-number variations (CNVs) with clinical-grade precision.
يقوم هذا الفحص بتسلسل كامل الإكسونات المشفرة ومواقع الوصل الجيني لجين CIITA لتحديد الطفرات النقطية والحذف والإدراج وتغيرات عدد النسخ بدقة سريرية عالية.
| Parameter | Our Test (Gold Standard) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity — Full Gene Coverage (Exons + Splice Sites + CNV) | ~95% — Targeted Panel, Limited CNV Detection |
| Methodology | NGS (Illumina NovaSeq) + LC-MS/MS Confirmatory Validation | Sanger Sequencing Only (Single-Exon Resolution) |
| Speed | 21–28 Calendar Days (Expedited Available) | 4–6 Weeks |
| Regulatory | DHA-MOHAP Aligned, ISO 9001:2015 Certified | Variable Accreditation |
Physician Insight & Safety Protocol
Clinical Note from Dr. Prabhakar Reddy (DHA License: 61713011, Consultant Clinical Pathologist & Molecular Geneticist): "A positive CIITA variant finding is a molecular diagnosis, not a clinical sentence — it empowers families with clarity for hematopoietic stem cell transplantation planning and carrier screening. I urge every patient to understand that this genetic result must be correlated with immunological workup including lymphocyte subset analysis and HLA-DR flow cytometry before any treatment decision is made. You are not alone in this journey; our team provides full tele-genetic counselling to walk you through every implication with compassion and scientific precision."
Medication Safety Warning
Do not discontinue any prescribed medication — including immunosuppressants, corticosteroids, or prophylactic antibiotics — without consulting your treating physician. Genetic test results provide diagnostic clarity but do not replace ongoing clinical management. Abrupt medication cessation in immunodeficient patients may precipitate severe, life-threatening infections.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed with Home Draw If):
- Patient is currently febrile (>38.5°C) or has active systemic infection
- Patient has received allogeneic blood transfusion within 14 days (may cause sample chimerism)
- Patient is under 6 months of age without paediatric phlebotomy specialist confirmation
- Known EDTA or latex allergy (alternative collection kits available upon request)
Emergency Red Flags — Seek Immediate Medical Attention:
- Respiratory distress, cyanosis, or oxygen saturation below 92%
- New-onset seizures or altered consciousness
- Signs of septic shock: hypotension, tachycardia, mottled skin
- Severe allergic reaction (anaphylaxis) post-collection
For medical emergencies, call 998 (UAE Ambulance) immediately. Do not wait for test results.
UAE Regulatory & Legal Compliance
Federal Decree-Law No. 41 of 2024 (Art. 87): This genetic test is processed exclusively within a DHA-licensed facility (License No. 9834453) adhering to mandatory genetic counselling requirements prior to and following testing. All genetic data is classified as sensitive personal data under UAE law.
CDS Law 2026 — Minor Protection: Genetic testing of individuals under 18 years of age requires documented guardian consent and mandatory pre-test genetic counselling. Carrier testing of asymptomatic minors is restricted per UAE paediatric ethics guidelines.
UAE PDPL (Personal Data Protection Law): All genomic data is stored on encrypted, UAE-sovereign servers with zero cross-border transfer without explicit consent. Data retention and destruction protocols comply with Article 13 of the UAE PDPL.
ISO 9001:2015 Certification: Our facility holds active certification INT/EGQ/2509DA/3139, audited annually for quality management systems encompassing pre-analytical, analytical, and post-analytical phases.
Patient FAQ & Clinical Guidance
Q1: What is the CIITA gene test and why would a dermatologist or immunologist order it for my child?
Snippet Answer: The CIITA Genetic Test is a definitive molecular diagnostic tool that identifies pathogenic mutations causing Bare Lymphocyte Syndrome Type II, a severe primary immunodeficiency presenting in infancy with recurrent infections, chronic dermatitis, and failure to thrive — enabling early hematopoietic stem cell transplant planning and family genetic counselling.
This is ordered when clinical suspicion arises from recurrent opportunistic infections (Pneumocystis jirovecii pneumonia, persistent candidiasis), severe eczema unresponsive to standard therapy, hypogammaglobulinemia, and absent HLA-DR expression on flow cytometry. Dermatologists often serve as the first point of contact because cutaneous manifestations — severe seborrheic dermatitis, erythroderma, and chronic mucocutaneous candidiasis — are among the earliest visible signs of BLS II. Confirmation via NGS enables definitive diagnosis, differentiates from SCID and other combined immunodeficiencies, and guides curative therapy.
هذا الفحص الجيني يُشخّص متلازمة الخلايا الليمفاوية العارية بدقة جزيئية، ويُستخدم عندما تظهر على الرضيع التهابات جلدية مزمنة والتهابات تنفسية متكررة مع نقص في الغلوبولينات المناعية، مما يستدعي تدخلاً طبياً عاجلاً لتخطيط زراعة الخلايا الجذعية.
Q2: How accurate is NGS technology for detecting CIITA mutations, and what happens if my result is inconclusive?
Snippet Answer: Our NGS platform achieves 99.9% diagnostic sensitivity with full coverage of all 20 CIITA coding exons, splice-site junctions (±20 bp intronic flanking regions), and copy-number variant detection, validated by orthogonal LC-MS/MS confirmation — reducing inconclusive rates to under 0.5%.
In the rare event of an inconclusive result (variant of uncertain significance — VUS), our genetic counselling team provides a complimentary family segregation analysis (testing both biological parents at no additional cost) to clarify variant pathogenicity using ACMG/AMP 2026 criteria. Results are reported in a clinically actionable format with explicit recommendations for immunological correlation, HLA-DR flow cytometry, and referral to a tertiary immunodeficiency centre in the UAE.
في حالات النتائج غير الحاسمة، تُقدم استشارة وراثية مجانية مع فحص الوالدين لتوضيح أهمية الطفرة الجينية وفق معايير الكلية الأمريكية لعلم الوراثة الطبية.
Q3: Can I use my UAE health insurance to cover the 2800 AED cost, and how does the home collection process work?
Snippet Answer: Yes, we provide direct insurance billing verification within 15 minutes via WhatsApp at +971 54 548 8731 — simply send a photo of your Emirates ID and insurance card, and our team confirms coverage before your scheduled home phlebotomy appointment, which is available 8 AM–11 PM across all seven Emirates.
Our home collection service deploys a DHA-licensed phlebotomist to your location with a temperature-controlled cold-chain transport kit (2°C–8°C, continuous monitoring via IoT data loggers). The collection uses either a standard venipuncture (EDTA tube, 3–5 mL whole blood) or a painless finger-prick FTA card (single drop) for paediatric patients. Samples are transported directly to our ISO-certified laboratory; you receive GPS-tracked custody updates via SMS. Turnaround time is 21–28 calendar days, with expedited 14-day processing available for medical urgency (supporting letter from referring physician required).
نعم، يتم التحقق من تغطية التأمين الصحي عبر واتساب خلال 15 دقيقة، مع خدمة سحب الدم المنزلي المبرد والمعتمد من هيئة الصحة بدبي في جميع الإمارات من الثامنة صباحاً حتى الحادية عشرة مساءً.
Clinical Entity Grounding — 2026 Medical Coding Reference
Primary ICD-10-CM (2026)
D81.6 — Major Histocompatibility Complex Class II Deficiency (Bare Lymphocyte Syndrome Type II)
Secondary ICD-10-CM (2026)
D81.9 — Combined Immunodeficiency, Unspecified | Z13.79 — Encounter for Screening for Other Genetic Disorders
LOINC Code
81247-8 — Genetic Variant Interpretation Panel (NGS)
https://loinc.org/81247-8/
© 2026 DNA Labs UAE — DHA Licensed Facility No. 9834453 | All genetic testing performed in accordance with Federal Decree-Law No. 41 of 2024 and UAE PDPL.
WhatsApp Support & Insurance Verification: +971 54 548 8731 | Available 8 AM – 11 PM (GMT+4) | Home Collection Across All Emirates: Abu Dhabi, Dubai, Sharjah, Ajman, Umm Al Quwain, Ras Al Khaimah, Fujairah
مركز معتمد من هيئة الصحة بدبي | جميع الحقوق محفوظة | الامتثال الكامل للقانون الاتحادي رقم 41 لسنة 2024
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