Test Price
2,800 AED✅ Home Collection Available
CDKL5 Gene Analysis for Early Infantile Epileptic Encephalopathy Type 2 (NGS) in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
This DHA-licensed genetic analysis detects pathogenic variants in the CDKL5 gene using advanced Next-Generation Sequencing (NGS) with a diagnostic sensitivity of 99.9%. The test includes ISO-certified cold-chain home blood collection, a detailed clinical report, and post-test genetic counseling. Results are available within 3–4 weeks. Price: 2800 AED, inclusive of sample collection and interpretation.
Test Overview & Methodology
The CDKL5 Gene NGS Test targets all coding exons and splice sites of the CDKL5 gene to identify mutations responsible for Early Infantile Epileptic Encephalopathy Type 2 (EIEE2). This method significantly outperforms traditional Sanger sequencing in both breadth and speed, enabling precise diagnosis and tailored therapeutic strategies.
| Feature | Our Test (NGS at DNA Labs UAE) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (covers all coding exons & splice sites) | ~95% (limited to specific known variants) |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Sample Collection | VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM – 11 PM) | Clinic visit only |
| Clinical Reporting | Detailed NGS report with ICD-10-CM G40.4, LOINC 97515‑4, and DHA‑compliant interpretation | Limited to identified mutation |
| Regulatory Alignment | Federal Decree-Law No. 45 of 2021 (PDPL), Federal Law No. 2 of 2019 (Health ICT), and Federal Decree-Law No. 4 of 2016 (Medical Liability) | May not explicitly reference latest UAE genetic privacy laws |
Physician Insight & Safety Protocols
“Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes: ‘A positive CDKL5 result must be correlated with clinical seizure semiology and EEG findings; it is not a standalone diagnosis. Our multidisciplinary team offers immediate post-test genetic counselling to guide antiepileptic therapy and family planning.’”
Advisory: Medication Safety
⚠ Antiepileptic Drug Warning
Do not discontinue prescribed antiepileptic drugs or alter dosing without consulting your neurologist. Abrupt withdrawal can trigger life‑threatening status epilepticus.
Exclusion Criteria & Emergency Red Flags
- Acute febrile illness or active infection requiring hospitalisation – reschedule blood draw.
- Known coagulopathy or current anticoagulant therapy – must be addressed by your physician prior to collection.
- If your child experiences prolonged seizures (>5 min), breathing difficulty, or unresponsiveness, proceed immediately to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is CDKL5 deficiency disorder and why is this NGS test recommended?
CDKL5 deficiency disorder is a rare X-linked genetic condition causing early-onset epileptic encephalopathy and intellectual disability. This NGS test provides a comprehensive genetic confirmation, enabling targeted treatment and family planning.
2. Why choose NGS over traditional Sanger sequencing for CDKL5 analysis?
NGS covers all coding exons and splice sites of the CDKL5 gene with 99.9% sensitivity in 3–4 weeks, whereas Sanger sequencing is limited to known variants and takes longer. NGS also detects novel mutations critical for accurate diagnosis.
3. Are home blood collection services available across the UAE?
Yes, our ISO‑certified phlebotomists provide VIP mobile phlebotomy and temperature-controlled cold-chain home collection daily from 8 AM to 11 PM across all Emirates, including Dubai, Abu Dhabi, Sharjah, and the Northern Emirates.
UAE Regulatory & Data Privacy Adherence
This test is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is handled with strict confidentiality and encrypted storage.
DNA Labs UAE operates under DHA Facility License Number 1143 and is accredited with ISO 9001:2015 (Certificate INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | CDKL5 Gene Analysis for Early Infantile Epileptic Encephalopathy Type 2 (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) or FTA card / DNA |
| Methodology Used | Next-Generation Sequencing (NGS), covering all coding exons and splice sites |
| ICD-10-CM Code | G40.4, G40.819, Z13.71 |
| LOINC Code | 97515-4 |
| DHA Facility License & Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians