Test Price
2,800 AEDโ Home Collection Available
CBLIF Gene Intrinsic Factor Deficiency Genetic Test in UAE
Executive Summary & Core Metrics
Diagnostic Precision: 99.9% clinical sensitivity achieved through ISO-compliant next-generation sequencing and rigorous variant interpretation protocols.
Logistics Excellence: VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM, staffed by DHA-licensed nursing personnel.
Clinical Guidance: Complimentary post-test tele-consultation with a consultant medical geneticist to contextualize results, discuss family screening, and coordinate specialist referrals.
Insurance Facilitation: Direct coverage verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) assay analyzes the CBLIF gene to detect pathogenic variants associated with intrinsic factor deficiency โ a hereditary condition that impairs vitamin B12 absorption and predisposes individuals to pernicious anemia. The test is performed under DHA-approved protocols using a peripheral whole blood specimen or extracted DNA, with results delivered within 3โ4 weeks accompanied by a comprehensive clinical interpretation from a molecular geneticist.
| Feature | CBLIF NGS Test | Standard B12 / Intrinsic Factor Antibody Panel |
|---|---|---|
| Molecular Precision | Full gene sequencing + ACMG-classified variant interpretation | Not applicable (serological markers only) |
| Method | Next-Generation Sequencing (NGS) | Immunoassay / Chemiluminescence |
| Turnaround Time | 3โ4 Weeks | 1โ3 Days |
| Clinical Actionability | Identifies carriers, confirms hereditary deficiency, guides family cascade screening | Detects current B12 deficiency or antibody presence; does not identify genetic cause |
| Specialist Collaboration | Consultant Medical Geneticist, Hematologist, Gastroenterologist | General Practitioner / Hematologist |
Physician Insight & Safety Protocols
โA pathogenic variant in CBLIF does not invariably lead to clinically overt disease; therefore, I strongly recommend correlating NGS findings with serum B12, methylmalonic acid, and homocysteine levels before initiating lifelong therapy. As a consultant medical geneticist practicing in Dubai, I emphasize that this test achieves its highest clinical utility when interpreted within the full context of family history, hematologic indices, and nutritional status.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Important: Do not alter or discontinue any prescribed therapy โ including vitamin B12 injections, proton pump inhibitors, metformin, or immunosuppressants โ without prior consultation with your treating physician. This genetic test serves as a diagnostic adjunct and does not replace ongoing clinical management or medication adjustments made by your healthcare provider.
Exclusion Criteria & Emergency Red Flags
Patient Safety Advisory
- Exclusion: This genetic test is not intended for acute or emergency settings. Do not postpone emergency care while awaiting results.
- Exclusion: Not indicated as a first-line investigation for newly diagnosed macrocytic anemia โ baseline B12, folate, and intrinsic factor antibody studies should be completed prior to genetic testing.
- Emergency Red Flags: If you experience sudden shortness of breath, chest pain, confusion, syncope, or profound weakness, call 998 (UAE ambulance) immediately. These symptoms may indicate severe anemia or neurologic compromise requiring urgent medical intervention.
- Paediatric Advisory: For individuals under 18 years, genetic counselling and written parental consent are mandatory, consistent with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does a positive CBLIF mutation result mean for my health?
A positive result indicates that you carry one or two pathogenic variants in the CBLIF gene, which can impair intrinsic factor production and reduce vitamin B12 absorption, placing you at increased lifelong risk for pernicious anemia and its neurological complications. Management typically includes regular B12 level monitoring and, when indicated, lifelong supplementation or injections prescribed by your hematologist. Family cascade screening is recommended for first-degree relatives.
2. What type of sample is required and how is it collected?
The test requires a peripheral whole blood sample, extracted DNA, or a dried blood spot on an FTA card. Saliva and hair samples are not accepted. Collection is performed by a DHA-licensed phlebotomist during a scheduled home visit under VIP mobile phlebotomy, with temperature-controlled cold-chain transport to the laboratory. Home collection is available daily from 8 AM to 11 PM.
3. How soon will I receive my results and who will explain them?
Results are delivered within 3 to 4 weeks and include an integrated clinical interpretation by a consultant medical geneticist and a hematologist. A scheduled tele-consultation is provided to discuss implications, family screening recommendations, and personalized follow-up. You may also request an in-person genetic counselling session after the report is issued.
4. Will my insurance cover this genetic test?
Coverage varies by insurance provider and policy. DNA Labs UAE offers direct verification of your benefits via WhatsApp at +971 54 548 8731. Pre-authorization may be required for genetic testing under certain plans. Our billing team will assist you with all documentation needed for reimbursement.
UAE Regulatory & Data Privacy Adherence
Your data is protected under UAE law. DNA Labs UAE fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted in transit and at rest, accessed only by authorized clinical personnel, and never shared with third parties without your explicit written consent. Clinical testing safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DHA Facility License: 1143.
Clinical & Logistical Metadata
| Test Name | CBLIF Gene Intrinsic Factor Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or dried blood spot (FTA card) โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM โ 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) with full CBLIF gene analysis and ACMG variant classification |
| ICD-10-CM Code | D51.0 |
| LOINC Code | 55231-3 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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