Test Price
2,800 AED✅ Home Collection Available
CAST Gene Peeling Skin with Leukonychia, Acral Punctate Keratoses, Cheilitis, and Knuckle Pads Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Precision Molecular Diagnostics for Hereditary Peeling Skin Syndrome
Diagnostic accuracy exceeding 99.9% through ISO-accredited Next-Generation Sequencing (NGS) technology. VIP mobile phlebotomy with temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Post-result tele-genetic counseling provided by a Consultant Medical Genetics specialist for integrated clinical interpretation. Direct insurance coverage verification via WhatsApp at +971545488731.
Test Overview & Methodology
The CAST gene NGS test delivers comprehensive molecular analysis of the CAST gene to confirm hereditary peeling skin syndrome associated with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads. This genetic confirmation enables precise clinical management, prognostic clarity, and targeted family counseling. The assay employs whole-exome capture with deep intronic coverage followed by Sanger confirmation of all pathogenic and likely pathogenic variants.
| Feature | Our Test (CAST NGS) | Clinical Diagnosis Only |
|---|---|---|
| Precision | 99.9% sensitivity for pathogenic variants | Depends on physical exam; may miss atypical forms |
| Method | Next-Generation Sequencing (NGS) with Sanger confirmation | None; based on clinical criteria alone |
| Turnaround Time | 3–4 Weeks | Immediate (but no genetic certainty) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA Registration ID: 9294403)
“I recognize the profound emotional burden that chronic, unexplained skin conditions impose on patients and families. This focused genetic test can end a prolonged diagnostic odyssey and guide personalized dermatological management as well as informed family planning. While the molecular results are definitive, they must always be integrated with a thorough clinical evaluation and phenotypic correlation.”
Clinical Advisory
Medication Continuation & Therapeutic Guidance
Do not discontinue or alter any prescribed medication without consulting your treating physician. Genetic test results provide diagnostic and prognostic information and should never be interpreted as a standalone directive to change therapy. Always correlate molecular findings with clinical history and dermatological assessment before making treatment decisions.
Safety Exclusion Criteria & Emergency Indicators
- Not indicated for asymptomatic individuals with no family history of CAST-related peeling skin syndrome.
- For minor patients, mandatory parental or legal guardian consent is required per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags:
- Seek immediate medical attention if you experience widespread skin sloughing, fever, chills, or signs of cutaneous infection (purulent drainage, spreading erythema, swelling, or severe pain).
Patient FAQ & Clinical Guidance
1. What condition does the CAST gene test diagnose and who should consider it?
This advanced NGS test detects pathogenic mutations in the CAST gene responsible for hereditary peeling skin syndrome. The disorder is characterized by generalized skin peeling, leukonychia (white nails), acral punctate keratoses, cheilitis (lip inflammation), and knuckle pads. Genetic confirmation enables accurate prognosis, surveillance planning, and cascade screening of at-risk family members. Candidates include individuals with characteristic clinical features and those with a confirmed family history of the syndrome.
2. How is the test performed and what sample is required?
A standard peripheral whole blood sample or buccal swab collected by our certified phlebotomist provides sufficient DNA yield for analysis. We offer VIP mobile phlebotomy with temperature-controlled cold-chain home collection across the UAE daily from 8 AM to 11 PM. Alternatively, patients may visit our Dubai Healthcare City facility for sample submission. The laboratory employs next-generation sequencing with deep coverage of the CAST gene followed by orthogonal Sanger confirmation of all reportable variants.
3. Will my health insurance cover this genetic test and what is the self-pay cost?
We provide direct insurance billing verification — send your policy details via WhatsApp at +971545488731 for an instant coverage check. Many UAE insurers cover genetic testing when deemed medically necessary by a referring specialist. Our team assists with pre-authorization documentation. The self-pay cost is 2,800 AED, which includes the full NGS analysis, Sanger confirmation, and a post-result genetic counseling session with our Consultant Medical Genetics.
UAE Regulatory & Data Privacy Adherence
All genetic testing and associated data handling at DNA Labs UAE are performed in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the collection, processing, and storage of genetic and health data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — regulating electronic health records and telemedicine practices.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — ensuring patient safety, informed consent, and clinical accountability in diagnostic procedures.
Our laboratory is ISO 9001:2015 certified (Cert. INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143.
Clinical & Logistical Metadata
| Test Name | CAST Gene (Peeling Skin with Leukonychia, Acral Punctate Keratoses, Cheilitis, and Knuckle Pads) — NGS Analysis |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q82.8 |
| LOINC Code | 83519-7 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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