Test Price
2,800 AED✅ Home Collection Available
CARD11 Gene B-Cell Expansion with NF-κB and T-Cell Anergy Genetic Test in UAE
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Telephonic Post-Test Genetic Counselling with result interpretation by a DHA-licensed consultant medical geneticist.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Price: 2,800 AED — Full gene coverage by Next-Generation Sequencing with Sanger confirmation.
Test Overview & Methodology
The CARD11 NGS Test sequences the entire CARD11 gene to detect gain- or loss-of-function variants driving B-cell expansion, NF-κB pathway overactivation, and impaired T-cell anergy. This test is essential for diagnosing primary immunodeficiencies such as BENTA disease and CADINS syndrome, guiding targeted therapy, and assessing lymphoma risk in patients with unexplained lymphoproliferation or autoimmune features.
Specimen Requirements & Pre-Test Logistics
Accepted Samples:
- Whole Blood (EDTA tube, 2–5 mL)
- Extracted DNA (≥1 µg, concentration ≥50 ng/µL)
- Dried Blood Spot on FTA Card (one drop, properly air-dried)
Pre-Test Instructions:
A detailed clinical history and a genetic counselling session to construct a pedigree chart of family members affected by CARD11-related disorders are required before sample collection. No fasting or medication discontinuation is necessary; please inform the team of any recent blood transfusions or hematopoietic cell therapy. For minors, legally authorized consent is mandatory under Federal Decree-Law No. 4 of 2016 on Medical Liability.
| Feature | DNA Labs UAE Test | Closest Alternative (Regional Labs) |
|---|---|---|
| Precision | Full gene coverage (exons + splice sites) with 500x mean depth (99.9% sensitivity) | Partial exon sequencing or limited hotspot panel |
| Methodology | NGS (Next‑Generation Sequencing) + Sanger confirmation | Sanger sequencing only or unspecified NGS with low depth |
| Turnaround Time | 3–4 Weeks | 4–8 Weeks |
| Regulatory Compliance | DHA/MOHAP Licensed, ISO 9001:2015, UAE PDPL Compliant | May lack full DHA approval for genetic testing |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I have guided many families through the implications of CARD11 variants. This test provides critical information for diagnosing primary immunodeficiencies like BENTA disease, but results must always be interpreted within the full clinical context. I remind every patient that this genetic analysis is a tool for proactive management, not a definitive verdict."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed medication without consulting your treating physician. Immunosuppressive or anti-neoplastic drugs do not interfere with the genetic result but should only be adjusted under specialist supervision.
Safety Exclusion Criteria & Emergency Red Flags
- This test is not suitable for patients who have undergone allogeneic hematopoietic stem cell transplantation within the last 3 months due to donor DNA interference.
- Do not use ultra-low-volume dried blood spots below 20 µL due to risk of failed amplification.
- If you experience rapidly enlarging lymph nodes, unexplained fever, severe infection, or neurologic symptoms, seek immediate emergency care — do not wait for the genetic test result.
Patient FAQ & Clinical Guidance
1. What is the CARD11 genetic test and when is it recommended?
This comprehensive genetic test detects all variants in the CARD11 gene responsible for B-cell expansion and T-cell anergy. It is used to diagnose primary immunodeficiencies such as BENTA disease and CADINS syndrome, evaluate unexplained lymphoproliferation, and estimate lymphoma risk in patients with persistent immune dysregulation.
2. How accurate is the CARD11 NGS test and will my insurance cover it?
Our next-generation sequencing achieves 99.9% diagnostic sensitivity with Sanger confirmation of all reported variants, ensuring no false-positive or false-negative calls. Most UAE insurers cover genetic testing when pre-authorized; our team verifies your coverage directly via WhatsApp before sample collection.
3. Can this test be performed for children and what legal consents are required?
Yes, children can be tested with legally mandated parental or guardian consent as specified under Federal Decree-Law No. 4 of 2016 on Medical Liability. A mandatory pre-test genetic counselling session is required to explain the implications for the entire family.
UAE Regulatory & Data Privacy Adherence
All procedures at DNA Labs UAE strictly comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, access-controlled, and never shared without explicit consent. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility is DHA-licensed (License No. 1143) and ISO 9001:2015 certified.
Clinical & Logistical Metadata
| Test Name | CARD11 Gene B-Cell Expansion with NF-κB and T-Cell Anergy Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) + Sanger Confirmation |
| ICD-10-CM Code | D84.9 |
| LOINC Code | 55217-0 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
DNA Labs UAE — DHA Licensed Facility No. 1143 | ISO 9001:2015 Certified
Booking & Insurance Verification: WhatsApp +971 54 548 8731
Support: +971 54 548 8731 | 8 AM – 11 PM Daily | UAE PDPL Compliant
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