Test Price
2,800 AED✅ Home Collection Available
CACNA1S Gene: Thyrotoxic Periodic Paralysis Type 1 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity via ISO‑Accredited Next‑Generation Sequencing (NGS)
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM)
Telephonic Post‑Test Clinical Guidance in Result Interpretation – empowering you with expert insights.
Direct Billing Verification via WhatsApp: +971 54 548 8731
Test Overview & Methodology
The CACNA1S gene NGS test identifies pathogenic variants responsible for thyrotoxic periodic paralysis type 1, a rare autosomal dominant muscle channelopathy that causes episodic weakness triggered by thyrotoxicosis. The test covers all coding exons and splice sites to provide a definitive molecular diagnosis.
| Parameter | Our Precision NGS | Targeted Mutation Screening |
|---|---|---|
| Precision | >99.9% sensitivity for all coding/ splicing variants | Limited to predefined hotspots |
| Method | Next Generation Sequencing (NGS) | Sanger sequencing / PCR panel |
| Turnaround | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
From Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA: 9294403): “This test is a powerful tool for confirming the genetic basis of thyrotoxic periodic paralysis. I guide patients through the implications of their results, always alongside a complete clinical and family history review. My goal is to provide clarity and a roadmap for personalised treatment, not to create uncertainty.”
Safety Advisory
Do not discontinue prescribed medication without consulting your doctor. Thyrotoxicosis treatment requires close supervision; abruptly stopping anti‑thyroid drugs or beta‑blockers can precipitate a severe paralytic episode.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Known non‑thyrotoxic hypokalemic periodic paralysis (e.g., Andersen‑Tawil syndrome); pregnancy – genetic testing only after careful risk‑benefit evaluation.
- ER Red Flags: Sudden, severe limb paralysis or difficulty breathing, cardiac palpitations/arrhythmia, or a drop in potassium below 2.5 mmol/L during an attack – seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What does the CACNA1S gene test involve?
A simple blood draw or dried blood spot sample is collected via VIP Mobile Phlebotomy at your home, then analysed by NGS for pathogenic variants across the entire coding region.
2. How accurate is this genetic test?
Our ISO‑accredited laboratory delivers 99.9% diagnostic sensitivity for detecting known and novel CACNA1S mutations, providing a near‑definitive molecular diagnosis.
3. Is genetic counselling required before the test?
Yes, a pre‑test genetic counselling session is mandatory per DHA guidelines to discuss implications and draw a family pedigree. This ensures informed consent and proper interpretation.
UAE Regulatory & Data Privacy Adherence
Legal Framework Compliance
This genetic test is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted and processed under strict confidentiality. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | CACNA1S Gene: Thyrotoxic Periodic Paralysis Type 1 Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | G72.3 |
| LOINC Code | 48019-1 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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