Test Price
2,800 AED✅ Home Collection Available
C5 Gene (Complement C5) Deficiency Genetic Test in UAE | 2800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic post-test clinical correlation session with Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA ID 9294403).
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- Price: 2,800 AED – all-inclusive, no hidden fees.
Test Overview & Methodology
This advanced Next‑Generation Sequencing (NGS) test screens the entire coding region of the C5 gene for pathogenic variants causing complement component 5 deficiency—a rare primary immunodeficiency linked to recurrent invasive Neisseria infections and autoimmune manifestations. The molecular analysis detects single‑nucleotide variants, insertions, deletions, and copy‑number alterations down to 1% variant allele frequency, providing a definitive diagnosis for terminal complement pathway defects.
| Parameter | Our C5 Gene NGS Test | Classical Complement Functional Assay (CH50/AH50) |
|---|---|---|
| Precision | Single‑nucleotide & copy‑number variant resolution down to 1% variant allele frequency | Semi‑quantitative pathway activity only; cannot pinpoint the defective component |
| Methodology | Next‑Generation Sequencing (NGS), Illumina NovaSeq™, validated bioinformatics pipeline | Hemolytic plate assay / ELISA |
| Turnaround Time | 3 to 4 Weeks (definitive molecular diagnosis) | 1 Week (screening only) |
Physician Insight & Safety Protocols
“Genetic results are not a standalone verdict; they must be interpreted within your full clinical picture. I urge every patient to discuss the findings with a clinical immunologist or geneticist before making any health or family planning decisions.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Medication Advisory
⚠️ Medication Warning
Do not discontinue any prescribed prophylactic antibiotics or immunomodulatory therapy without consulting your treating physician.
Exclusion Criteria & Emergency Red Flags
- Genetic testing is contraindicated without a pre‑test genetic counselling session (mandatory pedigree evaluation).
- Minors (below 18 years) require explicit parental consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Home collection may be contraindicated for individuals with known bleeding disorders or on high‑dose anticoagulants without INR monitoring; in such cases, hospital extraction can be arranged.
- Seek immediate emergency care if you develop sudden high fever with petechial rash, severe headache, or neck stiffness – these could signal meningococcemia.
Patient FAQ & Clinical Guidance
1. What is the C5 gene and how does its deficiency affect my immunity?
The C5 gene encodes complement component C5, a critical protein in the terminal complement pathway. Its deficiency prevents formation of the membrane attack complex (C5b‑9), severely impairing the immune system's ability to clear Neisseria bacteria. Individuals with biallelic loss‑of‑function mutations face a 500‑fold increased risk of meningococcal disease, recurrent invasive infections, and autoimmune conditions such as cutaneous vasculitis. Molecular diagnosis via NGS confirms the genetic defect, enabling targeted vaccination, antibiotic prophylaxis, and family cascade screening.
2. Who should consider this C5 deficiency genetic test?
Testing is recommended for anyone with a personal or family history of invasive meningococcal disease, recurrent neisserial infections (e.g., N. meningitidis meningitis or bacteremia), or symptoms suggestive of a terminal complement defect—such as unexplained systemic autoimmune features that are poorly responsive to immunosuppression. Pre‑test genetic counselling is mandatory to document informed consent and construct a pedigree chart identifying at‑risk relatives.
3. How is the sample collected and what are the pre‑test precautions?
The test requires a single peripheral blood draw (2–5 mL) or an extracted DNA sample. No fasting is necessary. Our DHA‑licensed phlebotomist performs home collection between 8 AM and 11 PM using a temperature‑controlled cold chain (2–8°C). You must complete a genetic counselling session prior to collection to provide consent and family history. Please bring any prior immunological or complement reports and do not alter your prophylactic antibiotics unless directed by your physician.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Compliance
This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Laboratory operations are ISO 9001:2015 accredited (Cert: INT/EGQ/2509DA/3139) and licensed under DHA Facility License No. 1143. All genetic data is handled confidentially and in strict compliance with UAE health data protection standards.
Clinical & Logistical Metadata
| Test Name | C5 Gene (Complement C5) Deficiency Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral blood |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | D84.1 |
| LOINC Code | 81405-5 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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