Test Price
2,800 AED✅ Home Collection Available
BTK Gene (X-Linked Agammaglobulinemia Type 1) Genetic Test in UAE | 2,800 AED | DHA Licensed Lab
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Specialist post-test clinical guidance and genetic counselling integration.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The BTK gene NGS test definitively identifies mutations in the Bruton’s tyrosine kinase gene responsible for X-linked agammaglobulinemia (XLA) – a severe primary immunodeficiency characterized by recurrent bacterial infections and absent B-cells. Early molecular confirmation via NGS is critical for initiating immunoglobulin replacement therapy and prophylactic antibiotics.
| Feature | Our BTK NGS Test | Alternative (Sanger Sequencing / Panel) |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity – full gene coverage including deep intronic regions | Limited to exonic hotspots; may miss novel or large deletions |
| Methodology | Next-Generation Sequencing (NGS) with CNV calling | Sanger sequencing / targeted mutation panel |
| Turnaround Time | 3 to 4 Weeks | 4 to 6 Weeks (often longer for full gene) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403 shares: “Confirming XLA via comprehensive BTK sequencing provides families with a definitive molecular answer after extended periods of diagnostic uncertainty. This result directly guides life-saving interventions such as immunoglobulin replacement therapy. However, genetic findings must always be correlated with immunological phenotypes and clinical presentation. Continuous specialist follow-up is mandatory; interruption of established therapy poses significant risks.”
Advisory & Medication Safety
⚠️ Medication Safety: Do not discontinue prescribed immunoglobulin therapy or antibiotics without explicit consultation with your managing physician.
Exclusion Criteria & Emergency Red Flags
- Excluded: Genetic testing for asymptomatic minors requires explicit consent from a legal guardian and pre-test genetic counselling.
- Excluded: Patients unable to provide informed consent for genetic analysis; a mandatory genetic counselling session is required.
- Excluded: Recent blood transfusion (within 2 weeks) may interfere with DNA analysis; a pre-transfusion sample is recommended.
- ER Red Flag: If the patient experiences high fever, severe respiratory distress, or signs of overwhelming infection, proceed immediately to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the BTK genetic test for X-linked agammaglobulinemia (XLA)?
The BTK NGS test comprehensively analyzes the Bruton’s tyrosine kinase gene to confirm XLA, a hereditary immunodeficiency causing absent B cells and recurrent bacterial infections. The results enable timely initiation of immunoglobulin replacement therapy and prophylactic antibiotics.
2. How accurate is this DNA test and what sample types are accepted?
Offering 99.9% diagnostic sensitivity, our NGS assay uses peripheral whole blood, extracted DNA, or a single drop on an FTA card for rapid, non-invasive collection. Results are typically available within 3 to 4 weeks.
3. Do I need genetic counselling before taking this test?
Yes, UAE regulations mandate pre- and post-test genetic counselling. Our genetic counsellors will explain the implications of the test, draw a family pedigree, and support you throughout the testing process.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols are governed under Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | BTK Gene (X-Linked Agammaglobulinemia Type 1) Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV calling |
| ICD-10-CM Code | D80.0 |
| LOINC Code | 55221-2 |
| DHA Facility License & Laboratory Address | License No: 1143 / Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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