Test Price
900 AED✅ Home Collection Available
BCL6 Gene Rearrangement (FISH) in UAE | 900 AED | DHA Licensed Molecular Diagnostics
Executive Summary & Core Metrics
Rigorous molecular cytogenetic analysis of BCL6 gene rearrangements at 3q27 for B-cell lymphoma classification, delivered under ISO accredited processing.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The BCL6 FISH test identifies chromosomal rearrangements of the BCL6 gene at 3q27, a critical prognostic and diagnostic marker in B-cell lymphomas. Dual-fusion break-apart probes provide high-resolution detection superior to conventional karyotyping and immunohistochemistry.
| Parameter | Our Test (BCL6 FISH) | Closest Alternative (IHC / Karyotyping) |
|---|---|---|
| Precision & Sensitivity | 99.9% sensitivity; dual-fusion probes detect subtle break-apart signals missed by standard methods | IHC: ~85% concordance; karyotyping: low resolution (5–10 Mb) may miss cryptic rearrangements |
| Methodology | Fluorescence In-Situ Hybridization (FISH) on interphase nuclei from bone marrow aspirate or peripheral blood | Immunohistochemistry (IHC) for BCL6 protein; conventional cytogenetics requires live cells and longer culture |
| Turnaround Time | 5–6 working days | Karyotyping: 10–14 days; IHC: 3–4 days but less molecular detail |
| Sample Requirement | 2–3 mL bone marrow aspirate in EDTA or 5 mL peripheral blood in EDTA | Tissue block required for IHC; large blood volume for karyotyping |
Physician Insight & Safety Protocols
“A BCL6 rearrangement detected by FISH is a valuable molecular clue but never a standalone diagnosis. Integrated interpretation with histopathology, immunohistochemistry, and clinical presentation remains essential. Patients should understand that genetic results guide but do not replace comprehensive oncologic evaluation. Medication adjustments must always be supervised by the treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notes on Result Interpretation
Critical Clinical Caution
This test provides molecular data that must be correlated with full clinical context. A positive BCL6 rearrangement does not independently diagnose lymphoma; it must be interpreted alongside histology, immunohistochemistry, and clinical presentation. Never discontinue or alter prescribed medications based solely on this test result without direct consultation with your oncologist or hematologist.
Exclusion Criteria & Procedural Red Flags
- Exclusions (Test Not Indicated): Pre‑surgical clearance, routine pregnancy evaluation, travel‑related health screening, or general wellness check‑ups.
- Sample Condition: Inadequate or clotted bone marrow/peripheral blood samples will be rejected; repeat collection may be required.
- Emergency Symptoms: If you experience rapid lymph node enlargement, unexplained fever, night sweats, or significant weight loss, seek immediate medical attention rather than relying on a scheduled test result.
Patient FAQ & Clinical Guidance
1. What is the BCL6 FISH test and why is it performed?
The BCL6 FISH test detects specific chromosomal translocations involving the BCL6 gene at 3q27, essential for classifying aggressive B‑cell lymphomas. Accurate identification of this rearrangement directly influences prognosis and targeted therapy decisions in diffuse large B‑cell lymphoma and related subtypes.
2. How should I prepare for the sample collection?
No special fasting is required. A trained phlebotomist will collect bone marrow under local anesthesia or draw peripheral blood within a controlled hospital environment, ensuring minimal discomfort and maximum specimen integrity.
3. How accurate is the BCL6 FISH test and can it rule out lymphoma?
With 99.9% analytical sensitivity, a negative result strongly argues against a BCL6‑associated rearrangement, but a definitive lymphoma diagnosis always requires tissue biopsy and comprehensive histopathologic evaluation. This test is an adjunctive molecular assessment, not a replacement for tissue diagnosis.
4. Will my insurance cover the cost of this test?
Coverage depends on your individual insurance policy and the medical necessity determined by your referring specialist. Direct billing verification can be initiated via WhatsApp at +971 54 548 8731 to determine eligibility and any applicable copayment.
UAE Regulatory & Data Privacy Adherence
Your genetic information is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing procedures and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE applies ISO-compliant data security frameworks to ensure confidentiality, integrity, and lawful processing of all genomic and personal health data.
Clinical & Logistical Metadata
| Test Name | BCL6 Gene Rearrangement (FISH) |
| Price (AED) | 900 |
| Turnaround Time | 5–6 working days |
| Sample Type / Matrix | Bone marrow aspirate (2–3 mL in EDTA) or peripheral whole blood (5 mL in EDTA) – Hospital Extraction Only |
| Methodology Used | Fluorescence In-Situ Hybridization (FISH) – dual-fusion break-apart probe strategy on interphase nuclei |
| ICD-10-CM Code | C83.9 |
| LOINC Code | 49583-7 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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