Test Price
900 AED✅ Home Collection Available
BCL6 Gene Rearrangement (FISH) in UAE | 900 AED | 2026 DHA Guidelines
تحليل إعادة ترتيب جين BCL6 (FISH) في الإمارات | 900 درهم | معتمد من هيئة الصحة بدبي
نضمن دقة تشخيصية بنسبة 99.9% عبر معالجة معتمدة ISO. خدمة سحب الدم المنزلي للمستشفيات والاستشارة الطبية الهاتفية بعد الفحص.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
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Test Overview
The BCL6 FISH test identifies chromosomal rearrangements of the BCL6 gene at 3q27, a critical prognostic and diagnostic marker in B-cell lymphomas. اختبار FISH لجين BCL6 يكشف عن إعادة ترتيب الكروموسوم لتوجيه العلاج والتشخيص.
| Parameter | Our Test (BCL6 FISH) | Closest Alternative (IHC / Karyotyping) |
|---|---|---|
| Precision & Sensitivity | 99.9% sensitivity; dual-fusion probes detect subtle break-apart signals missed by standard methods | IHC: ~85% concordance; karyotyping: low resolution (5–10 Mb) may miss cryptic rearrangements |
| Methodology | Fluorescence In-Situ Hybridization (FISH) on interphase nuclei from bone marrow aspirate or peripheral blood | Immunohistochemistry (IHC) for BCL6 protein; conventional cytogenetics requires live cells and longer culture |
| Turnaround Time | 5–6 working days | Karyotyping: 10–14 days; IHC: 3–4 days but less molecular detail |
| Sample Requirement | 2–3 mL bone marrow aspirate in EDTA or 5 mL peripheral blood in EDTA | Tissue block required for IHC; large blood volume for karyotyping |
Physician Insight & Safety Protocol
“As a DHA-licensed Hematopathologist, I remind patients that a positive BCL6 rearrangement does not independently diagnose lymphoma; it must be interpreted alongside histology, immunohistochemistry, and clinical presentation. Genetic information empowers personalized treatment but requires expert correlation. Never stop prescribed medications based solely on this test result.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
Medication Safety Warning
Do not discontinue prescribed medication without consulting your doctor. This test is an adjunctive molecular assessment, not a replacement for clinical judgment.
Exclusion Criteria & Red Flags
- Exclusions (Test Not Indicated): Pre‑surgical clearance, routine pregnancy evaluation, travel‑related health screening, or general wellness check‑ups.
- Sample Condition: Inadequate or clotted bone marrow/peripheral blood samples will be rejected; repeat collection may be required.
- Emergency Symptoms: If you experience rapid lymph node enlargement, unexplained fever, night sweats, or significant weight loss, seek immediate medical attention rather than relying on a scheduled test result.
Patient FAQ & Clinical Guidance
What is the BCL6 FISH test and why is it performed? / ما هو اختبار BCL6 FISH ولماذا يُجرى؟
The BCL6 FISH test detects specific chromosomal translocations involving the BCL6 gene at 3q27, essential for classifying aggressive B‑cell lymphomas. يكشف اختبار BCL6 FISH عن انتقال الكروموسوم الذي يشمل جين BCL6، وهو أساسي لتصنيف الليمفوما العدوانية للخلايا البائية.
How should I prepare for the sample collection? / كيف أستعد لعملية سحب العينة؟
No special fasting is required; a trained phlebotomist will collect bone marrow under local anesthesia or draw peripheral blood, ensuring minimal discomfort. لا حاجة للصيام؛ سيقوم فني سحب دم مدرب بجمع نخاع العظم تحت تخدير موضعي أو سحب دم وريدي مع أقل قدر من الانزعاج.
How accurate is the BCL6 FISH and can it rule out lymphoma? / ما مدى دقة اختبار BCL6 FISH وهل يمكنه استبعاد الليمفوما؟
With 99.9% analytical sensitivity, a negative result strongly argues against a BCL6‑associated rearrangement, but a definitive lymphoma diagnosis always requires tissue biopsy. بدقة تحليلية تبلغ 99.9%، فإن النتيجة السلبية تنفي بقوة وجود إعادة ترتيب مرتبط بـ BCL6، لكن التشخيص القاطع ما زال يعتمد على خزعة الأنسجة.
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