Test Price
2,800 AEDโ Home Collection Available
ASB10 Gene Glaucoma, Open-Angle Type 1F Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The ASB10 Gene Glaucoma, Open-Angle Type 1F Genetic Test comprehensively sequences the entire ASB10 gene to detect pathogenic variants linked to primary open-angle glaucoma (POAG). This assay enables UAE ophthalmologists to stratify genetic risk, initiate early surveillance, and personalise management long before irreversible optic nerve damage occurs.
| Feature | Our NGS Test | Standard POAG Genetic Panel |
|---|---|---|
| Methodology | High-depth Next-Generation Sequencing (NGS) with >99.9% analytical sensitivity | Sanger sequencing or targeted genotyping; limited variant coverage |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Price (AED) | 2,800 | 3,000โ3,500 |
| Gene Coverage | Full ASB10 coding region + deep intronic boundaries | Common hotspot variants only |
Physician Insight & Safety Protocols
โAs a Consultant in Medical Genetics, I emphasize that the ASB10 gene test provides definitive risk stratification for primary open-angle glaucoma. However, genetic results must always be interpreted alongside a comprehensive ophthalmological evaluation. A negative result does not exclude the possibility of glaucoma; lifelong monitoring remains essential.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed medication without consulting your doctor. Always follow your ophthalmologistโs guidance for intraocular pressure control.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: No absolute contraindications for routine venipuncture. Patients with severe coagulopathy (e.g., haemophilia) or active systemic infection should discuss alternative sample collection with their physician.
- Emergency Red Flags: If you experience sudden severe eye pain, blurred vision, halos around lights, or acute visual loss, seek immediate emergency ophthalmic care. These symptoms may indicate acute angle-closure glaucoma, a separate medical emergency unrelated to this genetic test.
- This test is not intended for acute diagnosis; it is an elective genetic risk assessment.
Patient FAQ & Clinical Guidance
1. What is the ASB10 gene and how does it cause glaucoma?
The ASB10 gene encodes a protein that regulates trabecular meshwork cell function; mutations elevate intraocular pressure and trigger open-angle glaucoma. ASB10 variants disrupt aqueous humour outflow, leading to progressive optic nerve damage typical of primary open-angle glaucoma. Testing confirms genetic predisposition even before clinical signs appear.
2. Who should undergo this genetic test?
Anyone with a strong family history of glaucoma or early-onset open-angle glaucoma should consider this NGS test. Candidates include individuals with a first-degree relative diagnosed with POAG, those diagnosed under age 40, or patients with atypical presentations. A mandatory pre-genetic counselling session draws a detailed pedigree chart and discusses potential outcomes.
3. What do the results mean for my eye health?
A pathogenic variant confirms elevated lifetime risk, warranting lifelong monitoring; a negative result reduces but never eliminates glaucoma risk. If a disease-causing mutation is detected, your ophthalmologist will implement a tailored surveillance schedule with regular intraocular pressure checks and advanced optic nerve imaging. Absence of a known mutation does not rule out other genetic or environmental factors; routine comprehensive eye exams remain essential.
UAE Regulatory & Data Privacy Adherence
- Data privacy assured per Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health information confidentiality per Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Parental consent mandatory for individuals below 18 years per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Certified Laboratory (Cert: INT/EGQ/2509DA/3139) โ sample processing follows stringent quality management systems.
- DHA Facility License No: 1143 โ Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | ASB10 Gene Glaucoma, Open-Angle Type 1F Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3-5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full gene sequencing including coding regions and deep intronic boundaries |
| ICD-10-CM Code | Z13.5 (Encounter for screening for genetic disease), H40.11 (Primary open-angle glaucoma) |
| LOINC Code | 104198-4 (ASB10 gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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