Test Price
2,800 AED✅ Home Collection Available
ARL6 Gene Bardet‑Biedl Syndrome Type 3 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل طفرة جين ARL6 لمتلازمة بارد بيدل النوع 3 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy.
Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
ملخص تنفيذي: اختبار جيني عالي الدقة لتشخيص متلازمة بارد بيدل النوع 3 عبر تقنية التسلسل الجيني المتقدم، مع استشارة وراثية شاملة معتمدة من هيئة الصحة بدبي وضمان الخصوصية الكاملة.
Overview
This next‑generation sequencing (NGS) test analyzes the entire coding region of the ARL6 gene to detect pathogenic variants causing Bardet‑Biedl Syndrome Type 3 (BBS3), a multisystem ciliopathy affecting kidneys, liver, eyes, and endocrine function. Delivered with 99.9% diagnostic sensitivity through ISO‑certified labs, the test provides a definitive molecular diagnosis guiding targeted management and family planning.
يقوم اختبار التسلسل الجيني (NGS) هذا بتحليل الجين ARL6 بالكامل لكشف الطفرات المسببة لمتلازمة بارد بيدل نوع 3، وهو اضطراب وراثي متعدد الأجهزة يمكن أن يؤثر على الكلى والكبد والعينين والغدد الصماء. بنسبة حساسية تصل إلى 99.9%، يوفر الاختبار تشخيصًا جزيئيًا دقيقًا يوجه العلاج المخصص والتخطيط الأسري.
| Feature | Our Test (PrimeGenix) | Closest Alternative |
|---|---|---|
| Precision | NGS with full gene coverage, 99.9% analytical sensitivity | Sanger sequencing of ARL6 (single gene) or Whole Exome Sequencing |
| Methodology | Next‑Generation Sequencing (Illumina) + Sanger confirmation | WES covers many genes but may miss deep intronic variants without specific ARL6 analysis |
| Turnaround Time | 3‑4 Weeks (ISO‑certified) | 4‑8 Weeks for WES with bioinformatics filtering |
| Post‑Test Support | Free telephonic clinical guidance and genetic counseling referral | Usually report only without guided interpretation |
| Price | 2800 AED | ~3500‑5000 AED |
Pre‑Test Information & Genetic Counseling Requirement
Mandatory Pre‑Test Preparation: A detailed clinical history and a genetic counseling session to draw a pedigree chart of affected family members are required before sample collection. This ensures accurate variant interpretation and compliance with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) for informed consent.
Sample Collection Options: Whole blood (2‑5 mL in EDTA tube), extracted DNA (≥1 µg), or one drop of blood on FTA card. No fasting or medication adjustments needed.
Note: Do not discontinue any prescribed medications without consulting your doctor. This genetic test is not affected by current medications.
Physician Insight & Safety Protocol
Clinical Correlation Required: Dr. Prabhakar Reddy (DHA License 61713011), Senior Molecular Geneticist, emphasizes: “A positive ARL6 variant confirms Bardet‑Biedl syndrome type 3 only when correlated with the patient’s clinical picture—obesity, polydactyly, retinitis pigmentosa, renal anomalies. A negative result does not exclude other BBS genes or atypical presentations, so comprehensive clinical evaluation remains essential.”
Medication Warning: Do not discontinue prescribed medication without consulting your physician. Genetic test results should never alter current therapy without medical review.
Exclusion Criteria & Emergency Red Flags
- This test is not for prenatal diagnosis without an invasive procedure; discuss with a fetal medicine specialist.
- If the patient has received a hematopoietic stem cell transplant, interpretation may be confounded (consider alternative tissue).
- Emergencies: Seek immediate care if the patient experiences acute kidney failure, severe vision loss, or respiratory distress—these are not related to the test but to underlying syndrome complications.
- Test results are not a substitute for urgent clinical management.
Frequently Asked Questions
What is the ARL6 gene test for Bardet‑Biedl syndrome type 3, and when is it recommended?
Snippet: This NGS test analyzes the ARL6 gene to confirm Bardet‑Biedl syndrome type 3 in patients presenting with obesity, polydactyly, retinitis pigmentosa, renal anomalies, or hypogonadism, recommended for diagnostic confirmation and family screening.
The test is indicated when clinical features suggest a ciliopathy, particularly in children or adults with the classic triad of obesity, retinal dystrophy, and postaxial polydactyly. Early diagnosis enables proactive monitoring of renal function, metabolic status, and vision, while allowing accurate genetic counseling for relatives.
يوصى بهذا الاختبار الجيني لتأكيد تشخيص متلازمة بارد بيدل من النوع الثالث لدى المرضى الذين يعانون من السمنة وتعدد الأصابع والتهاب الشبكية الصباغي وتشوهات الكلى وقصور الغدد التناسلية، وكذلك لفحص أفراد الأسرة المعرضين للخطر.
How accurate is the ARL6 NGS test, and can it detect all mutations?
Snippet: With 99.9% analytical sensitivity for single nucleotide variants and small indels within the ARL6 coding region, the test does not detect large genomic deletions/duplications beyond Sanger verification scope—additional MLPA may be required.
Our NGS pipeline paired with Sanger confirmation ensures exceptionally high specificity (>99.99%). However, deep intronic or promoter variants, and copy number changes outside the targeted region, may need complementary techniques like MLPA or array CGH for complete assessment.
يصل الاختبار إلى حساسية تحليلية تبلغ 99.9% للتغيرات النقطية والطفيلات الصغيرة في منطقة الجين ARL6، لكنه لا يكشف عن حذف أو مضاعفات جينية كبيرة؛ الأمر الذي قد يتطلب فحصًا إضافيًا مثل تقنية MLPA.
What is the process for home sample collection in UAE, and is the covered by insurance?
Snippet: Our ISO‑certified home phlebotomy service collects blood samples between 8 AM and 11 PM across the UAE, and we verify direct billing with most insurers via WhatsApp at +971 54 548 8731.
A trained phlebotomist arrives at your doorstep with a temperature‑controlled transport kit. The sample is immediately logged into a chain‑of‑custody system. Pre‑authorization for insurance is confirmed digitally; self‑pay patients receive a detailed invoice. Results are securely delivered within 3‑4 weeks.
تتوفر خدمة سحب العينات من المنزل بين الساعة 8 صباحًا و11 مساءً في جميع أنحاء الإمارات، ويمكن التحقق من تغطية التأمين عبر الواتساب على الرقم +971 54 548 8731.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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