Test Price
2,800 AED✅ Home Collection Available
ARL6 Gene Bardet‑Biedl Syndrome Type 3 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection (available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
Test Overview & Methodology
This next‑generation sequencing (NGS) test analyzes the entire coding region of the ARL6 gene to detect pathogenic variants causing Bardet‑Biedl Syndrome Type 3 (BBS3), a multisystem ciliopathy affecting kidneys, liver, eyes, and endocrine function. Delivered with 99.9% diagnostic sensitivity through ISO‑certified labs, the test provides a definitive molecular diagnosis guiding targeted management and family planning.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative |
|---|---|---|
| Precision | NGS with full gene coverage, 99.9% analytical sensitivity | Sanger sequencing of ARL6 (single gene) or Whole Exome Sequencing |
| Methodology | Next‑Generation Sequencing (Illumina) + Sanger confirmation | WES covers many genes but may miss deep intronic variants without specific ARL6 analysis |
| Turnaround Time | 3‑4 Weeks (ISO‑certified) | 4‑8 Weeks for WES with bioinformatics filtering |
| Post‑Test Support | Free telephonic clinical guidance and genetic counseling referral | Usually report only without guided interpretation |
| Price | 2800 AED | ~3500‑5000 AED |
Physician Insight & Safety Protocols
Consultant Medical Genetics: Lina Osama Zaki Quteineh | DHA Registration ID: 9294403
“A positive ARL6 variant confirms Bardet‑Biedl syndrome type 3 only when correlated with the patient’s clinical picture—obesity, polydactyly, retinitis pigmentosa, renal anomalies. A negative result does not exclude other BBS genes or atypical presentations, so comprehensive clinical evaluation remains essential.”
Advisory: Pre‑Test Genetic Counseling Requirement
Mandatory Pre‑Test Preparation: A detailed clinical history and a genetic counseling session to draw a pedigree chart of affected family members are required before sample collection. This ensures accurate variant interpretation and compliance with Federal Decree‑Law No. 4 of 2016 on Medical Liability for informed consent.
Sample Collection Options: Whole blood (2‑5 mL in EDTA tube), extracted DNA (≥1 µg), or one drop of blood on FTA card. No fasting or medication adjustments needed.
Exclusion Criteria & Emergency Red Flags
- This test is not for prenatal diagnosis without an invasive procedure; discuss with a fetal medicine specialist.
- If the patient has received a hematopoietic stem cell transplant, interpretation may be confounded (consider alternative tissue).
- Emergencies: Seek immediate care if the patient experiences acute kidney failure, severe vision loss, or respiratory distress—these are not related to the test but to underlying syndrome complications.
- Test results are not a substitute for urgent clinical management.
Patient FAQ & Clinical Guidance
1. What is the ARL6 gene test for Bardet‑Biedl syndrome type 3, and when is it recommended?
This NGS test analyzes the ARL6 gene to confirm Bardet‑Biedl syndrome type 3 in patients presenting with obesity, polydactyly, retinitis pigmentosa, renal anomalies, or hypogonadism, recommended for diagnostic confirmation and family screening. The test is indicated when clinical features suggest a ciliopathy, particularly in children or adults with the classic triad of obesity, retinal dystrophy, and postaxial polydactyly. Early diagnosis enables proactive monitoring of renal function, metabolic status, and vision, while allowing accurate genetic counseling for relatives.
2. How accurate is the ARL6 NGS test, and can it detect all mutations?
With 99.9% analytical sensitivity for single nucleotide variants and small indels within the ARL6 coding region, the test does not detect large genomic deletions/duplications beyond Sanger verification scope—additional MLPA may be required. Our NGS pipeline paired with Sanger confirmation ensures exceptionally high specificity (>99.99%). However, deep intronic or promoter variants, and copy number changes outside the targeted region, may need complementary techniques like MLPA or array CGH for complete assessment.
3. What is the process for home sample collection in UAE, and is it covered by insurance?
Our ISO‑certified home phlebotomy service collects blood samples between 8 AM and 11 PM across the UAE, and we verify direct billing with most insurers via WhatsApp at +971 54 548 8731. A trained phlebotomist arrives at your doorstep with a temperature‑controlled transport kit. The sample is immediately logged into a chain‑of‑custody system. Pre‑authorization for insurance is confirmed digitally; self‑pay patients receive a detailed invoice. Results are securely delivered within 3‑4 weeks.
UAE Regulatory & Data Privacy Adherence
This test is conducted in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, access‑controlled, and processed solely for diagnostic purposes. All genetic results are handled with strict confidentiality and in accordance with the DHA‑mandated data protection frameworks. Emergency red flags remain separate from the routine testing pathway.
Clinical & Logistical Metadata
| Test Name | ARL6 Gene Bardet‑Biedl Syndrome Type 3 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3‑4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card |
| Methodology Used | Next‑Generation Sequencing (Illumina) + Sanger Confirmation |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 51990-0 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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