Test Price
2,800 AED✅ Home Collection Available
AR Gene Hypospadias Type 1, X-Linked Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The AR gene (androgen receptor) X-linked test identifies pathogenic variants causing hypospadias type 1 through comprehensive next-generation sequencing (NGS). This assay provides full coverage of all coding exons, intronic boundaries, and the promoter region of the AR gene located on the X chromosome.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision & Detection | 99.9% sensitivity for single nucleotide variants and small indels across entire AR gene, including deep intronic regions | Limited to a few pre‑selected exons; may miss critical regulatory or deep intronic variants |
| Methodology | NGS on Illumina NovaSeq 6000 with Sanger confirmation for pathogenic calls | Sanger sequencing of individual amplicons; lower throughput and no CNV analysis |
| Turnaround Time | 3–4 weeks (standard) | 2–3 weeks (variable) |
| Regulatory Compliance | ISO 9001:2015 Certified; DHA‑Licensed Facility; Federal Decree-Law No. 45 of 2021 (PDPL) compliant | May lack full ISO accreditation for genetic testing |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I recognize the emotional weight families carry when pursuing genetic answers. This NGS-based AR gene test delivers a precise molecular diagnosis for X-linked hypospadias type 1, yet it is essential that results are interpreted alongside a thorough clinical evaluation and a three-generation family history. Please do not alter any ongoing treatment without a dedicated genetic counseling session.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Interaction Alert
Do not discontinue prescribed hormonal therapies (e.g., androgens or anti‑androgens) without consulting your specialist. These medications can alter androgen receptor function and may affect genetic test interpretation. Only adjust under direct clinical supervision.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Severely hemolyzed or clotted blood sample – recollect required. No test is performed on insufficient DNA quantity.
- Emergency Red Flags: If you develop excessive bleeding, expanding hematoma, signs of infection (redness, warmth, pus) at the venipuncture site, or fever >38°C, seek immediate medical attention.
- Minors: For children under 18, written informed consent from a parent or legal guardian is required as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the AR gene and how does it cause hypospadias type 1?
Quick Answer: Mutations in the AR gene impair androgen receptor function, leading to androgen insensitivity and disrupted male urethral fold development, causing hypospadias type 1. This test identifies pathogenic variants in the AR gene to confirm a genetic cause.
2. How is the genetic test performed and what sample is needed?
Quick Answer: A simple blood draw (peripheral whole blood in an EDTA tube) or a dried blood spot on an FTA card is collected. DNA is extracted and analyzed using next-generation sequencing (NGS) on the Illumina NovaSeq 6000 platform.
3. Can this test be done for a child, and what are the UAE regulations?
Quick Answer: Yes. For minors, written informed consent from a parent or legal guardian is mandatory. The test must be clinically indicated, and results are provided with post-test genetic counseling. UAE law (Federal Decree-Law No. 4 of 2016 on Medical Liability) governs pediatric genetic testing.
UAE Regulatory & Data Privacy Adherence
Data Protection: This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted and stored on UAE-based servers.
Accreditation: ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Facility licensed by the Dubai Health Authority (DHA License No: 1143).
Clinical & Logistical Metadata
| Test Name | AR Gene Hypospadias Type 1, X-Linked Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (Lavender Top EDTA Tube) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq 6000 with Sanger confirmation for pathogenic calls |
| ICD-10-CM Code | Q54.0 (Hypospadias, Type 1) |
| LOINC Code | 21636-6 (Androgen receptor gene mutation analysis) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Operated by DNA Labs UAE |
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