Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3 to 4 weeks
APOA1 Gene Amyloidosis, Familial Visceral Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (ISO 9001:2015 Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetic specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Price: 2800 AED inclusive of genetic counselling and results delivery.
Test Overview & Methodology
The APOA1 Genetic Test screens for pathogenic variants in the apolipoprotein A-1 gene, the definitive cause of familial visceral amyloidosis. Using next-generation sequencing with 300x average read depth, it delivers unequivocal genetic confirmation for symptomatic patients and at-risk relatives. The test analyzes all coding exons and flanking intronic regions, detecting single nucleotide variants, small insertions/deletions, and copy number changes implicated in amyloid fibril deposition in the gut, liver, and kidneys.
| Feature | Our Test (UAE) | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing (all exons ยฑ20 bp) by NGS | Targeted mutation panel only |
| Method | Illumina NovaSeq, clinically validated bioinformatics | Sanger sequencing (selected regions) |
| Turnaround | 3 to 4 weeks with genetic counselling included | 6-8 weeks, often without counselling |
Physician Insight & Safety Protocols
Dr. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) shares: โA positive APOA1 variant does not stand alone as a diagnosis โ it must be interpreted alongside kidney, liver, and gastrointestinal evaluations. Even with a negative result, if clinical suspicion remains, whole-exome sequencing may be warranted. Genetic counselling before and after testing is non-negotiable.โ
Safety Advisory
Critical Pre-Test Precautions
Do not discontinue prescribed medication without consulting your doctor. Altering treatment based on genetic results without professional oversight can precipitate organ deterioration.
Exclusion Criteria & Emergency Red Flags
- Patients with active bleeding disorders or severe anaemia (phlebotomy risk).
- Neonates under 6 months โ capillary FTA card preferred; physician must approve venipuncture.
- Inability to provide informed consent (mandatory for all genetic tests under UAE law).
- ER Red Flags: Sudden onset of severe abdominal pain, massive proteinuria, or acute liver failure require immediate emergency care, not elective genetic testing.
Patient FAQ & Clinical Guidance
1. What exactly does the APOA1 genetic test detect?
It detects pathogenic DNA variants in the APOA1 gene that cause hereditary visceral amyloidosis using next-generation sequencing technology. The test analyzes all coding exons and adjacent intronic splice sites, identifying single nucleotide variants, small insertions/deletions, and copy number changes known to trigger amyloid fibril deposition in the gut, liver, and kidney. A negative report reduces but does not completely eliminate the possibility of a different amyloidogenic mutation.
2. Is the home blood collection safe and DHA-approved?
All home collections follow DHAโs mobile phlebotomy standards using ISO-certified cold-chain transport and sterile single-use equipment. Our phlebotomists are MOHAP-licensed and operate between 8 AM and 11 PM, using butterfly needles for minimal discomfort. The FTA card option requires only a single drop of blood and is ideal for infants or patients with difficult veins. Samples are tracked with real-time temperature monitoring until they reach our accredited molecular lab.
3. How do I interpret the results and discuss them with a specialist?
A genetic counselor or your referring physician will review the report, explain variant significance, and recommend surveillance protocols. Results are delivered in a comprehensive PDF with technical variant classification (ACMG guidelines). A complimentary 15-minute teleconsultation with a DHA-licensed geneticist is included to clarify findings and guide family screening. If a variant of uncertain significance is reported, we advise periodic reanalysis at no additional cost for two years.
UAE Regulatory & Data Privacy Adherence
This test is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic information is stored in encrypted, geo-redundant servers within the UAE. Our laboratory holds ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and is licensed under DHA Facility License 1143. All clinical procedures are reviewed by Dr. Lina Osama Zaki Quteineh (DHA 9294403).
Clinical & Logistical Metadata
| Test Name | APOA1 Gene Amyloidosis, Familial Visceral Genetic Test |
| Price (AED) | 2800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AMโ11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq, 300x average read depth, full gene sequencing of all coding exons and flanking intronic regions |
| ICD-10-CM Code | E85.0 (Non-neuropathic heredofamilial amyloidosis) |
| LOINC Code | 21647-2 (APOA1 gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | License No. 1143; Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
Preparation Required
["No specific fasting required.", "Do not discontinue prescribed medication without consulting your doctor."]
Medically Reviewed by Dr. Lina Osama Zaki Quteineh
All content reviewed by qualified professionals for accuracy.
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians