Test Price
2,800 AED✅ Home Collection Available
AP2S1 Gene Familial Hypocalciuric Hypercalcemia Type 3 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Guaranteed 99.9% diagnostic sensitivity from ISO 15189:2022 accredited processing. Premium VIP mobile phlebotomy with temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM. Telephonic post-test clinical guidance included. Direct insurance billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test analyzes the AP2S1 gene for pathogenic variants causing familial hypocalciuric hypercalcemia type 3 (FHH3), a benign calcium-sensing disorder often misdiagnosed as primary hyperparathyroidism. Frequently requested by General Physicians, Geneticists, and Medical Researchers to differentiate unexplained hypercalcemia with low urinary calcium and to perform family cascade screening.
| Feature | AP2S1 NGS (Our Test) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS with full exon & splice‑site coverage | Sanger – single‑gene, limited coverage |
| Diagnostic Sensitivity | 99.9% (deep sequencing) | 95–97% |
| Turnaround Time | 3–4 weeks | 6–8 weeks (often outsourced) |
| LOINC Code | 94492‑9 (AP2S1 gene full mutation analysis) | N/A – typically not LOINC‑indexed |
| ICD‑10‑CM Codes | E83.52 – Familial hypocalciuric hypercalcemia · E83.51 – Hypocalciuric hypercalcemia · Z13.79 – Encounter for screening for other suspected endocrine disorder | |
Physician Insight & Safety Protocols
“As a genetic diagnostic tool, this test provides definitive differentiation between FHH3 and primary hyperparathyroidism, preventing unnecessary parathyroid surgery. However, clinical correlation with serum calcium, PTH, and family history is mandatory; a positive genetic result alone does not dictate management. We advise all patients to review results with their treating physician and never alter calcium or vitamin D intake without medical consultation.” — Lina Osama Zaki Quteineh (DHA License: 9294403)
Emergency & Medication Advisory
Do not discontinue prescribed medications (e.g., calcimimetics, diuretics, or supplements) without consulting your doctor. This test is for diagnostic confirmation, not to guide acute treatment changes. If you experience severe hypercalcemic crisis (lethargy, confusion, severe abdominal pain, cardiac arrhythmias, or coma), seek immediate emergency care.
Exclusion Criteria & Red Flags
- Exclusion: Recent blood transfusion (within 4 weeks) may interfere with germline DNA analysis in whole blood; consider a buccal swab instead.
- Exclusion: Active hematological malignancy with circulating tumor DNA could confound results; discuss with your genetic counselor.
- Red Flag – Seek Emergency Care: If you experience severe hypercalcemic crisis (lethargy, confusion, severe abdominal pain, cardiac arrhythmias, or coma), go to the nearest emergency department immediately. This test is not for acute crises.
Patient FAQ & Clinical Guidance
1. What does the AP2S1 gene test detect and how is it different from calcium blood tests?
The AP2S1 NGS test identifies inherited DNA mutations causing familial hypocalciuric hypercalcemia type 3, providing a definitive lifelong diagnosis that distinguishes this benign condition from primary hyperparathyroidism and eliminates unnecessary surgical interventions.
2. Can I use my health insurance to cover this genetic test in the UAE?
Most UAE insurers cover medically necessary genetic testing when pre‑authorized by a DHA‑licensed physician; we provide direct billing verification and pre‑approval assistance via WhatsApp at +971 54 548 8731 before sample collection.
3. How is the sample collected and what is the turnaround time to receive my AP2S1 genetic report?
A certified phlebotomist collects a simple blood sample (or a painless finger‑prick for an FTA card) during a 15‑minute home visit; results are securely delivered within 3–4 weeks with optional telephonic clinical interpretation. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available daily from 8 AM to 11 PM.
UAE Regulatory & Data Privacy Adherence
Compliance & Data Protection
This test is performed under the DHA Facility License Number 1143 at DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Data handling complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | AP2S1 Gene Familial Hypocalciuric Hypercalcemia Type 3 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) – full exon & splice‑site coverage |
| ICD-10-CM Code | E83.52, E83.51, Z13.79 |
| LOINC Code | 94492‑9 |
| DHA Facility License & Laboratory Address | DHA License 1143 – DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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