Test Price
2,800 AED✅ Home Collection Available
AMBN Gene Amelogenesis Imperfecta Type 1F Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – ISO-accredited NGS workflow with Sanger confirmation of pathogenic variants.
- Premium Home Collection – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance – Complimentary telephonic post-test result interpretation with a genetic counsellor.
- Insurance Verification – Direct billing support via WhatsApp at +971 54 548 8731. DHA coverage confirmed.
Test Overview & Methodology
The AMBN gene test analyses the entire coding region of the ameloblastin gene using next-generation sequencing to identify variants causing hypoplastic/hypomaturation type 1F amelogenesis imperfecta. It delivers a clinical-grade report ready for dental, dermatological, and genetic counselling workflows.
| Feature | Our Test (ISO 9001:2015) | Closest Alternative |
|---|---|---|
| Precision | NGS with ≥99% base accuracy at >30x coverage | Single-gene Sanger sequencing (targeted regions only) |
| Method | Hybridization capture NGS + CNV detection | Gene panel by mass spectrometry (limited variant types) |
| Speed | 3–4 weeks from sample receipt | Often 6–8 weeks with overseas send-outs |
| Actionable Report | ACMG 2025 classified, family pedigree integration | Lab-only variant list without genetic counselling support |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasise that the AMBN test must always be evaluated alongside full clinical findings and family history. A single variant report is not a complete diagnosis; it is a stepping stone for personalised management. Please do not initiate or alter dental treatment based solely on this test without consulting a specialist.”
Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403Advisory Notice
Do not discontinue or modify any prescribed medication (e.g., bisphosphonates, hormonal treatments, or supplements) without consulting your attending physician.
Safety Exclusion & Emergency Red Flags
- Exclusions: This test is not intended for prenatal diagnosis or preimplantation genetic testing (PGT) without a separate DHA-approved consent process. Minors (<18 years) require court-appointed guardian consent as per Federal Law No. 2 of 2019.
- Red Flags – Seek Immediate Care: If the patient experiences acute psychological distress, suicidal ideation, or severe anxiety after genetic counselling, contact your nearest emergency department or crisis line (Estijaba 800 1717). Do not attempt to draw blood if the patient has a known coagulopathy, active infection at the venipuncture site, or extreme needle phobia without medical supervision.
- Specimen Integrity: Samples collected on FTA cards must be completely dried at room temperature. Wet or improperly sealed cards will be rejected and a recollection requested.
Patient FAQ & Clinical Guidance
1. How accurate is the AMBN gene test and can it miss my mutation?
Our sequencing achieves >99.9% analytical sensitivity for single nucleotide variants and small insertions/deletions within the AMBN gene, with complete coverage of all exons at >30x depth. However, deep intronic variants or large chromosomal rearrangements beyond the NGS design may not be detected. A negative report does not exclude a clinical diagnosis of amelogenesis imperfecta, and further dental/genetic evaluation is recommended.
2. What is included in the test price?
The price of 2800 AED covers the full sequencing analysis, a detailed clinical report reviewed by a Consultant Medical Genetics, and a post-test telephonic consultation with a genetic counsellor. The sample collection itself is included in the price whether you opt for VIP home phlebotomy or visit our DHA-licensed facility in Dubai Healthcare City.
3. What happens if a variant of uncertain significance (VUS) is found?
All VUS are extensively reviewed against updated population databases, in silico predictors, and family segregation analysis before inclusion in the clinical report. We provide complimentary reanalysis for 24 months if new evidence upgrades the classification. The genetic counsellor will explain provisional management and recommend periodic clinical follow-up.
UAE Regulatory & Data Privacy Adherence
This test is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is stored locally on secure HIPAA-compliant servers. Patient consent is obtained per Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds a valid DHA Facility License and undergoes annual audits to ensure continued adherence to these frameworks.
Clinical & Logistical Metadata
| Test Name | AMBN Gene Amelogenesis Imperfecta Type 1F Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL EDTA) or buccal swab |
| Methodology Used | Hybridization capture next-generation sequencing (NGS) plus CNV analysis |
| ICD-10-CM Code | K00.5 |
| LOINC Code | 94302-5 |
| DHA Facility License & Laboratory Address | Facility No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians