Test Price
2,800 AED✅ Home Collection Available
ALS2 Gene Primary Lateral Sclerosis, Juvenile Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ALS2 للتصلب الجانبي الأولي الطفلي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary | ملخص تنفيذي
This test identifies pathogenic variants in the ALS2 gene, the definitive cause of juvenile primary lateral sclerosis (JPLS) and infantile-onset ascending hereditary spastic paralysis (IAHSP). With a 99.9% diagnostic sensitivity achieved through next-generation sequencing (NGS) performed at our ISO-certified facility, the report provides clinicians with actionable, DHA-compliant genetic evidence to guide prognosis, family planning, and early therapeutic intervention.
يحدد هذا التحليل الطفرات الممرضة في جين ALS2، وهو السبب المؤكد للتصلب الجانبي الأولي الطفلي. بدقة تشخيصية تبلغ 99.9% عبر تقنية التسلسل الجيني المتقدم وفق معايير هيئة الصحة بدبي، يوفر التقرير أدلة جينية قابلة للتنفيذ لتوجيه الرعاية السريرية والتخطيط الأسري.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited NGS Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO-Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance with a DHA-licensed genetic counselor.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Inclusions
- Full ALS2 gene sequencing (all exons ±20 bp)
- Copy number variation (CNV) analysis
- Bioinformatic reanalysis for variants of uncertain significance (VUS)
- Pre- and post-test genetic counseling session
- Family pedigree chart construction
Facility License: 9834453
ISO 9001:2015 Cert: INT/EGQ/2509DA/3139
Test Overview
This NGS-based test comprehensively analyzes the ALS2 gene for mutations causing juvenile primary lateral sclerosis (JPLS) and related motor neuron disorders. It delivers a definitive molecular diagnosis in as little as 3 weeks, leveraging a targeted, high-coverage sequencing approach that minimizes incidental findings compared to whole-exome tests.
| Feature | Our Test (ALS2‑NGS) | Closest Alternative (HSP Gene Panel) |
|---|---|---|
| Methodology | Targeted NGS with 500x mean depth | Multi-gene panel (30‑60 genes), often lower depth |
| Turnaround Time | 3–4 weeks | 6–8 weeks (typical) |
| Coverage of ALS2 | 100% of coding region + exon-intron boundaries | ≥98% (may miss deep intronic variants) |
| Interpretation | Gene‑specific ACMG classification with pediatric neurology input | Generalized variant calling, may require follow‑up |
| Genetic Counseling | Included: pre‑test pedigree & post‑test phone consultation | Often optional or outsourced |
Physician Insight & Safety Protocol
“Juvenile primary lateral sclerosis stems from biallelic ALS2 mutations, and this test provides families with the genetic certainty needed to navigate a challenging diagnosis. The results must always be correlated with clinical findings and neuroimaging by a pediatric neurologist. I strongly advise that patients do not make any treatment decisions without a thorough clinical correlation.”
— Dr. PRABHAKAR REDDY, DHA Lic. 61713011
⚠️ Medication Warning
Do not discontinue any prescribed medication (e.g., baclofen, tizanidine) or therapy based on genetic test findings alone. Always consult your treating physician before altering the treatment plan.
🔴 Safety & Exclusion Criteria
- Exclusion Criteria: Inability to provide a blood sample or FTA card; patients with severe coagulopathy (INR > 2.0) only after physician clearance; neonates under 3 kg unless medically justified.
- ER Red Flags: If the patient or family member experiences acute psychological distress, suicide ideation, or severe anxiety following result disclosure, seek immediate psychiatric emergency services or call 998 (UAE Ambulance).
- Genetic test results must be disclosed during a formal genetic counseling session; self-interpretation is strongly discouraged.
Frequently Asked Questions
1. How accurate is the ALS2 gene NGS test for diagnosing juvenile primary lateral sclerosis?
This targeted NGS test achieves 99.9% diagnostic sensitivity for detecting pathogenic ALS2 variants when performed on a blood sample in a DHA-licensed laboratory.
ما مدى دقة تحليل جين ALS2 بتقنية التسلسل الجيني المتقدم في تشخيص التصلب الجانبي الأولي الطفلي؟
يحقق هذا التحليل حساسية تشخيصية تبلغ 99.9% للكشف عن الطفرات المرضية في جين ALS2 عند إجرائه على عينة دم في مختبر مرخص من هيئة الصحة بدبي.
2. What sample types are accepted, and is a home collection available in Dubai?
We accept whole blood (3‑5 mL in EDTA), extracted DNA, or a single drop of blood on an FTA card; VIP home collection is available across UAE from 8 AM to 11 PM.
ما هي أنواع العينات المقبولة، وهل تتوفر خدمة سحب العينة المنزلية في دبي؟
نقبل الدم الكامل أو الحمض النووي المستخلص أو بقعة دم على بطاقة FTA ؛ خدمة السحب المنزلي لكبار الشخصيات متاحة في جميع أنحاء الإمارات من 8 صباحًا حتى 11 مساءً.
3. Will my health insurance cover the cost of the ALS2 genetic test in the UAE?
Direct billing verification is done through WhatsApp at +971 54 548 8731; many UAE insurers cover this when pre-authorized by a pediatric neurologist or clinical geneticist.
هل سيغطي تأميني الصحي تكلفة تحليل ALS2 الجيني في الإمارات؟
يتم التحقق من تغطية التأمين مباشرة عبر الواتساب على الرقم +971 54 548 8731؛ العديد من شركات التأمين في الإمارات تغطي هذا التحليل عند الموافقة المسبقة من طبيب أعصاب أطفال أو أخصائي جينات.
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التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians