Test Price
2,800 AED✅ Home Collection Available
ALOXE3 Gene Next-Generation Sequencing Test – Congenital Ichthyosiform Erythroderma in UAE | 2800 AED
Executive Summary & Core Metrics
✔ Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
✔ Premium Logistics
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
✔ Clinical Guidance
Telephonic Post-Test Genetic Counseling – interpretation of results with a genetics specialist.
✔ Insurance Support
Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) panel fully analyzes the ALOXE3 gene, detecting point mutations, small indels, and copy number variants associated with nonbullous congenital ichthyosiform erythroderma. In the UAE, our ISO‑certified laboratory delivers results within 3–4 weeks, with integrated pre‑ and post‑test genetic counseling conducted in both English and Arabic.
| Feature | Our NGS Test (ALOXE3) | Closest Alternative (Sanger Single‑Gene) |
|---|---|---|
| Methodology | High‑coverage NGS + MLPA for copy number variants | Sanger sequencing, limited to selected exons |
| Precision | >99.9% analytical sensitivity & specificity for all coding variants | ~95% sensitivity for targeted regions; misses deep intronic/CNV |
| Turnaround | 3–4 Weeks | 4–6 Weeks (often outsourced) |
| CNV Detection | Included (MLPA confirmed) | Not routinely available |
| Counseling Support | Pre‑ & post‑test genetic counseling in Arabic & English | Variable, often not included |
Physician Insight & Safety Protocols
“Molecular diagnostics provide powerful clarity when combined with clinical correlation. As a Consultant Medical Genetics, I emphasize that the ALOXE3 variant interpretation must be integrated with a complete dermatological and family history for meaningful patient management.” – Lina Osama Zaki Quteineh (DHA License No. 9294403)
⚠ Important Medication Advisory
Do not discontinue any prescribed medication without consulting your treating doctor. This test does not replace medical management.
Exclusion Criteria & Safety Flags
- This test is not intended for individuals without clinical suspicion or a confirmed family history of congenital ichthyosis.
- It is not a standalone diagnostic tool; genetic counseling is mandatory before and after testing.
- If the patient exhibits severe blistering, signs of systemic infection, or acute skin failure, seek immediate emergency medical attention.
- Minors require documented informed consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability; parental/guardian consent must accompany the request.
Patient FAQ & Clinical Guidance
1. What is the ALOXE3 gene test used for?
This test diagnoses nonbullous congenital ichthyosiform erythroderma by detecting pathogenic variants in the ALOXE3 gene with 99.9% sensitivity.
2. How accurate is next-generation sequencing for detecting ALOXE3 mutations?
NGS achieves >99.9% analytical sensitivity and specificity for all coding variants and copy number changes, far exceeding older methods.
3. Why should I choose this test in the UAE?
Our DHA‑licensed facility provides cold‑chain home collection, ISO‑certified processing, and post‑test genetic counseling in Arabic and English.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and informed consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | ALOXE3 Gene Next-Generation Sequencing (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection; available 8 AM – 11 PM) |
| Methodology Used | High-coverage NGS + MLPA for copy number variant confirmation |
| ICD-10-CM Code | Q80.2 (Nonbullous congenital ichthyosiform erythroderma) |
| LOINC Code | 81247-9 (ALOXE3 gene targeted mutation analysis in blood) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians