Test Price
2,800 AED✅ Home Collection Available
ALG12 Gene Glycosylation Disorder Type 1G Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Clinical & Operational Assurance
The ALG12 gene NGS test screens for pathogenic variants causing Congenital Disorder of Glycosylation Type 1G (ALG12‑CDG) with full gene coverage. Report delivery within 3–4 weeks via accredited ISO 9001:2015 laboratory processes.
Test Overview & Methodology
Our comprehensive DNA analysis uses next‑generation sequencing (Illumina®) to detect single nucleotide variants, small insertions/deletions, and copy number variants across the entire ALG12 gene. Confirmatory Sanger sequencing is performed for clinically significant variants. Results are interpreted according to ACMG guidelines and include metabolic phenotype correlation.
| Feature | Our Test (ALG12 NGS) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Precision | Full gene coverage; detects SNVs, indels, CNVs | Targeted exons only; limited variant types |
| Methodology | Illumina® NGS with confirmatory Sanger | Sanger sequencing of selected regions |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Clinical Report | ACMG‑compliant with metabolic interpretation | Basic variant description |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA License 9294403): “An ALG12‑CDG diagnosis requires careful clinical correlation; this test is a powerful piece of the puzzle but must be interpreted alongside metabolic biomarkers and family history. As a clinical geneticist, I always advise that positive results be discussed with a board‑certified genetic counsellor before any lifestyle or therapeutic decisions.”
Advisory – Medication Safety
Do Not Discontinue Prescribed Therapy
⚠️ Do not stop or alter any prescribed medication without consulting your doctor. This genetic test does not replace current therapeutic management and must be used as a complementary diagnostic tool only.
Exclusion Criteria & Emergency Red Flags
Who Should NOT Proceed Without Medical Clearance:
- Individuals currently in acute metabolic crisis (e.g., unexplained vomiting, lethargy, hypoglycaemia).
- Patients with unstable haemodynamic status (requiring ICU care).
- Children under 13 years without valid parental consent (per UAE law for minors).
Seek Immediate Emergency Care If You Experience:
- Rapid neurological deterioration (seizure, loss of consciousness).
- Severe coagulopathy (unexplained bleeding/bruising).
- Signs of liver failure (jaundice, ascites) in a known CDG patient.
Patient FAQ & Clinical Guidance
1. What does the ALG12 NGS test detect and how long does it take?
It screens the entire ALG12 gene for pathogenic variants linked to congenital disorder of glycosylation type 1G, delivering a detailed report within 3–4 weeks from sample receipt.
2. Is a genetic counselling session mandatory before sample collection?
Yes, a pre‑test genetic counselling session is required to draw a pedigree chart, discuss implications, and obtain informed consent; this is included in the service package.
3. How does the home collection service ensure sample stability for DNA testing?
Our ISO‑certified cold‑chain logistics team uses validated EDTA tubes, maintaining DNA integrity from home to lab without degradation. The sample remains stable under temperature‑controlled conditions throughout transport.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA Facility License No. 1143). All personal genetic data is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent, data encryption, and secure storage protocols are embedded in every step of the testing lifecycle. Clinical safety and patient rights are further governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | ALG12 Gene Glycosylation Disorder Type 1G Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) – Peripheral Venous Blood; VIP Mobile Phlebotomy available |
| Methodology Used | Next‑Generation Sequencing (Illumina®) with confirmatory Sanger sequencing |
| ICD-10-CM Code | E77.8 (Other disorders of glycoprotein metabolism) |
| LOINC Code | 92789-1 (ALG12 gene sequencing) |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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