Test Price
2,800 AEDโ Home Collection Available
ADAMTS2 Gene Ehlers-Danlos Syndrome Type 7C (Dermatosparaxis) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Next-Generation Sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Consultation for result interpretation by DHA-licensed genetic specialists.
- Insurance: Direct Billing Verification instantly via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ADAMTS2 gene encodes an enzyme essential for proper collagen processing; mutations cause the rare Ehlers-Danlos syndrome type VIIC (dermatosparaxis), characterized by severe skin fragility, joint hypermobility, and distinctive skeletal abnormalities. Our NGS test sequences the entire coding region of ADAMTS2 to detect pathogenic variants, enabling definitive diagnosis and tailored management.
| Feature | Our ADAMTS2 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) โ full gene coverage with CNV analysis | Conventional Sanger โ limited to exon-only hotspots |
| Diagnostic Yield | >99% for known pathogenic variants & novel mutations | ~85% โ may miss deep intronic or regulatory variants |
| Turnaround Time | 3โ4 Weeks (Rush option available) | 4โ6 Weeks |
Physician Insight & Safety Protocols
โA positive ADAMTS2 result can be overwhelming, but it opens the door to precise surveillance for musculoskeletal and skin complications. Genetic diagnosis is only one piece of the puzzleโclinical correlation by a dermatologist or clinical geneticist is essential for a complete picture. Our team, led by Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403), ensures compassionate interpretation and next-step guidance.โ
Advisory & Safety Precautions
Medication Warning
Do not discontinue any prescribed medication, especially blood thinners or immunosuppressants, without consulting your treating physician before or after testing.
Emergency Red Flags (Post-Collection): Seek immediate medical attention if you experience uncontrolled bleeding from the venipuncture site, sudden swelling, signs of infection (fever, purulent discharge), or severe dizziness.
Exclusion Criteria & Pre-Test Requirements
Exclusion Criteria
This test requires informed consent; minors must have legal guardian authorization. Recent blood transfusion (<2 weeks) may compromise DNA quality and should be communicated during pre-test counseling.
Pre-Test Requirement: All patients undergo a mandatory genetic counseling session to document a complete pedigree chart of family members affected by or at risk of ADAMTS2-related dermatosparaxis. This session ensures accurate interpretation of results and compliance with UAE genetic data regulations.
Patient FAQ & Clinical Guidance
1. What is the ADAMTS2 gene test used for?
This test detects ADAMTS2 mutations causing dermatosparaxis, the most severe skin fragility form of Ehlers-Danlos syndrome, enabling accurate diagnosis, genetic counseling, and family planning.
2. How does the home collection service work in the UAE?
A DHA-licensed phlebotomist arrives at your home between 8 AM and 11 PM using ISO-certified cold chain transport, ensuring sample integrity from collection to laboratory analysis.
3. Will my insurance cover this genetic test?
We provide direct insurance billing verification within minutes via WhatsApp at +971 54 548 8731; many UAE providers cover genetic testing when medically indicated by a dermatologist or geneticist.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
This test strictly follows Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our facility, DNA Labs UAE, holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA License Number 1143.
Physical Address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | ADAMTS2 Gene Ehlers-Danlos Syndrome Type 7C (Dermatosparaxis) Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3โ4 Weeks (Rush option available) |
| Sample Type / Matrix | Peripheral whole blood (3-5 mL in EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) โ full gene coverage with CNV analysis |
| ICD-10-CM Code | Q79.6, Z14.01, Z82.79 |
| LOINC Code | 81247-7 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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