Test Price
2,800 AED✅ Home Collection Available
ADAM22 Gene Neurodevelopmental Disorder NGS Test in Dubai & Abu Dhabi
Executive Summary & Core Metrics
The ADAM22 gene NGS test is a high-precision molecular diagnostic assay designed to detect pathogenic variants associated with severe neurodevelopmental disorders and early-onset epileptic encephalopathy. This test is processed under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) and strictly adheres to DHA regulatory standards.
- Diagnostic Sensitivity: 99.9% for ADAM22 pathogenic variants.
- Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM - 11 PM).
- Post-Test Support: Telephonic consultation with a DHA-licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The ADAM22 Gene Neurodevelopmental Disorder NGS Test utilizes next-generation sequencing on the Illumina platform, targeting all coding exons and flanking intronic regions of the ADAM22 gene. Bioinformatic analysis is performed according to ACMG guidelines to identify single nucleotide variants (SNVs), small insertions/deletions (indels), and copy number variations (CNVs).
| Feature | DNA Labs UAE ADAM22 NGS Test | Standard Whole Exome Sequencing |
|---|---|---|
| Precision | Targeted, high-depth coverage (99.9% sensitivity) | Broader coverage, lower depth for specific genes |
| Turnaround | 3-4 weeks | 6-8 weeks |
| Cost | 2,800 AED | 4,000 – 5,000 AED |
| Incidental Findings | Minimized (targeted analysis) | Higher rate of secondary findings |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist practicing in the UAE, I emphasize that molecular confirmation of ADAM22-related disorders is critical for accurate prognosis, recurrence risk assessment, and targeted therapeutic interventions. A negative result significantly reduces the likelihood of ADAM22 pathology but does not exclude all genetic etiologies. Results must be interpreted within the full clinical context by a qualified specialist.”
– Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Continuity Advisory
Patients and caregivers must not alter or discontinue any prescribed antiepileptic or neurodevelopmental medications without explicit consultation with the treating neurologist. Abrupt cessation may precipitate severe withdrawal symptoms or status epilepticus.
Exclusion Criteria & Emergency Red Flags
- Clinically unstable patients unsuitable for standard venipuncture.
- Uncorrected coagulopathy or active hemorrhagic episode.
- Inability to obtain informed consent (must be provided by a legal guardian for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Emergency: For status epilepticus, acute developmental regression, or prolonged altered consciousness, call 998 or proceed to the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is the ADAM22 gene and how does it affect neurodevelopment?
The ADAM22 gene encodes a protein critical for synaptic function in the brain. Pathogenic variants disrupt neuronal signaling, leading to early-onset epileptic encephalopathy, severe intellectual disability, and autism spectrum traits. This NGS test identifies disease-causing mutations with high precision, enabling accurate diagnosis and family planning.
2. Who is the ideal candidate for this genetic test?
Children presenting with unexplained developmental delay, refractory seizures, global developmental regression, or a strong family history of neurodevelopmental disorders are ideal candidates. Pre-test genetic counseling is mandatory to document family pedigree and obtain informed consent.
3. How is the sample collected, and what is the turnaround time?
A standard peripheral whole blood sample (5-10 mL) is required. DNA Labs UAE offers VIP Mobile Phlebotomy services with temperature-controlled cold-chain logistics for home collection, available daily from 8 AM to 11 PM. Results are typically available within 3-4 weeks from sample receipt.
4. What does the post-test genetic counseling involve?
A detailed telephonic consultation with our DHA-licensed Consultant Medical Geneticist is provided to explain the results, discuss recurrence risks, and guide further clinical management, including referrals to pediatric neurology specialists in Dubai Healthcare City.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: DNA Labs UAE strictly complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, securely stored, and processed under strict confidentiality protocols. Clinical consent and liability are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
DHA Compliance: Our laboratory operates under DHA Facility License Number 1143, ensuring adherence to the highest standards of quality and safety in diagnostic genetic testing.
Clinical & Logistical Metadata
| Test Name | ADAM22 Gene Neurodevelopmental Disorder NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (5-10 mL) or Saliva (Oragene DNA Kit) |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina Platform with ACMG-Guided Bioinformatics |
| ICD-10-CM Code | G40.89 (Other seizures), F70-F79 (Intellectual disabilities), F84.0 (Autistic disorder) |
| LOINC Code | 101246-3 (Neurological disorder associated gene mutation panel) |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians