Test Price
2,800 AED✅ Home Collection Available
ADA2 Gene Sequencing for Childhood-Onset Polyarteritis Nodosa | 2,800 AED | DHA Licensed Test at DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA‑licensed experts.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Corporate Lab: DNA Labs UAE – DHA Facility License No. 1143.
Test Overview & Methodology
The ADA2 Gene Sequencing for Childhood-Onset Polyarteritis Nodosa is a comprehensive Next‑Generation Sequencing (NGS) analysis that reads the entire coding region of the ADA2 gene to identify mutations causing deficiency of adenosine deaminase 2 (DADA2). This genetic test replaces clinical suspicion with molecular certainty, enabling early targeted therapy and family screening.
| Feature | Our ADA2 Genetic Test | Closest Alternative (Imaging/Clinical Criteria) |
|---|---|---|
| Diagnostic Precision | 99.9% mutation detection | Anatomic suspicion; no molecular confirmation |
| Methodology | NGS (Next‑Generation Sequencing) – full gene coverage | Doppler ultrasound, angiography, biopsy |
| Turnaround Time | 3 to 4 Weeks | Variable; often delayed by specialist referral |
| Clinical Actionability | Immediate genetic counselling & targeted therapy (e.g., anti‑TNF) | Empiric immunosuppression without genetic guidance |
Physician Insight & Safety Protocols
“As a DHA‑licensed Consultant Medical Geneticist, I emphasize that this genetic test is the gold standard for diagnosing deficiency of adenosine deaminase 2 (DADA2). However, results must always be correlated with clinical phenotype, inflammatory markers, and family history. A negative result does not exclude all vasculitides, while a positive finding guides life‑saving personalised therapy but requires multidisciplinary follow‑up.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not discontinue any prescribed medication without consulting your doctor. Abrupt cessation of immunosuppressants, corticosteroids, or antihypertensives can precipitate a life‑threatening vasculitic flare. Always inform the phlebotomist about current medications.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active severe infection (e.g., sepsis, meningitis), inability to obtain an adequate blood sample, or patient refusal.
- Red Flags – Seek Emergency Care Immediately: Sudden high fever >39 °C, acute severe abdominal pain, new neurological deficits (focal weakness, confusion), or rapidly progressive skin necrosis. These may indicate an acute vasculitis crisis.
- Inform the phlebotomist of any bleeding disorder or anticoagulant use before the home collection.
Patient FAQ & Clinical Guidance
1. What exactly is the ADA2 gene test and how is it performed?
The ADA2 gene test is a blood‑based Next‑Generation Sequencing analysis that reads the entire coding region of the ADA2 gene to identify mutations causing childhood‑onset polyarteritis nodosa (DADA2). After a simple venous blood draw (or home collection), DNA is extracted and sequenced; results are returned in 3‑4 weeks with a comprehensive clinical interpretation.
2. Who should consider this test for their child?
Physicians recommend this test for any child presenting with recurrent unexplained fevers, skin nodules or livedo racemosa, early‑onset strokes or hypertension, or a family history of polyarteritis nodosa, because these features strongly suggest DADA2. Genetic counselling is mandatory before testing to assess inheritance and inform the family.
3. How does this affect management and insurance coverage in the UAE?
A positive result triggers immediate initiation of anti‑TNF therapy (often covered under UAE federal genetic disorder programmes), while negative findings redirect the diagnostic work‑up. Our team provides direct insurance verification via WhatsApp and ensures compliance with data protection frameworks.
UAE Regulatory & Data Privacy Adherence
Your data is protected in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- DHA Regulatory Standards for Genetic Testing and Laboratory Operations
DNA Labs UAE operates under DHA Facility License No. 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. All genetic results are handled with strict confidentiality and used only for diagnostic and therapeutic purposes.
Clinical & Logistical Metadata
| Test Name | ADA2 Gene Sequencing for Childhood-Onset Polyarteritis Nodosa |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (Venipuncture) – VIP Mobile Phlebotomy & Cold-Chain Home Collection Available |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage |
| ICD-10-CM Code | M30.0 (Polyarteritis nodosa) |
| LOINC Code | 95034-2 (ADA2 gene mutation detection in Blood) |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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