Test Price
2,800 AED✅ Home Collection Available
ACADM Gene (Medium-Chain Acyl-CoA Dehydrogenase Deficiency) Genetic Test in UAE – Comprehensive NGS Analysis
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed specialists.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Price: 2,800 AED – includes comprehensive report and genetic counseling.
Test Overview & Methodology
The ACADM Genetic Test sequences the entire coding region of the ACADM gene to detect pathogenic variants causing medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, a potentially life-threatening fatty acid oxidation disorder. This comprehensive analysis surpasses traditional targeted panels by identifying rare or novel mutations with 99.9% diagnostic sensitivity, enabling precise dietary intervention and prevention of metabolic crises in newborns, children, and adults across the UAE.
| Feature | Our ACADM NGS Test | Closest Alternative (Targeted PCR Panel) |
|---|---|---|
| Methodology | Next Generation Sequencing (NGS) – full gene | PCR for common mutations only |
| Variant Detection | All exonic & splice site variants, novel mutations | Pre‑defined hotspot mutations |
| Sensitivity | 99.9% | ~85% (missing rare variants) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Reporting | DHA‑compliant report with VUS interpretation | Basic result only |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA: 9294403: “A positive ACADM variant must be confirmed through orthogonal methods and correlated with acylcarnitine profiling. Autosomal recessive inheritance warrants carrier testing for at-risk family members. A negative result reduces suspicion for classic MCAD deficiency but does not exclude other fatty acid oxidation disorders. Always combine genetic data with clinical presentation for definitive diagnosis.”
Advisory – Medication & Dietary Precautions
Do not discontinue any prescribed medication or modify your child’s feeding regimen without consulting the treating physician. Genetic test results should always be interpreted within a full clinical context including metabolic profiles and physical examination.
Safety Exclusion Criteria & ER Red Flags
- Exclusion: Individuals with a history of severe bleeding disorders not managed by a physician.
- Exclusion: Children under 12 years without parental/guardian consent as per UAE Federal Law.
- Exclusion: Recent blood transfusion (within 4 weeks) – may interfere with germline DNA analysis.
- ER Red Flags – Seek Immediate Medical Attention: Vomiting, extreme lethargy, rapid breathing, hypoglycemia (blood sugar <50 mg/dL), or seizures. These may signal metabolic decompensation; do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What is an ACADM gene genetic test and why is it performed?
This NGS test detects mutations in the ACADM gene causing MCAD deficiency, a fatty acid oxidation disorder that can trigger life-threatening metabolic crises. The test is indicated for newborns with abnormal newborn screening, patients with unexplained hypoglycemia, or families with a history of sudden infant death. It provides a definitive molecular diagnosis, guiding lifelong dietary management to prevent fasting-induced decompensation.
2. How should I prepare for the blood sample collection for this genetic test in the UAE?
No fasting is required for a routine blood draw, but confirm with your doctor if any specific instructions apply. Our certified phlebotomist performs the home collection using a sterile EDTA tube. Ensure you provide complete family history and any previous metabolic test results. The pre-test genetic counseling session will help map a pedigree chart of affected family members, in compliance with DHA regulations.
3. What do the results of the ACADM gene test mean for my family’s health?
A positive result identifies a disease-causing mutation, confirming MCAD deficiency and enabling carrier testing for relatives. A negative result reduces the likelihood of classic MCAD deficiency but cannot rule out other metabolic or genetic disorders. If a variant of uncertain significance (VUS) is reported, further family segregation studies may be needed. All findings should be discussed with a clinical geneticist to understand autosomal recessive inheritance and future reproductive options.
4. Is home collection available for this genetic test?
Yes, our VIP Mobile Phlebotomy service enables sample collection at your home between 8 AM and 11 PM daily, including weekends. The sample is transported via temperature-controlled cold chain to our ISO 9001:2015 accredited laboratory in Dubai Healthcare City. This service is included in the test price with no additional fee.
5. How long does it take to receive results, and how are they delivered?
The standard turnaround time is 3–4 weeks from sample collection. Results are delivered via a secure online portal and a printed report can be mailed upon request. A follow-up telephonic consultation with a DHA-licensed genetic specialist is scheduled within 5 business days of report issuance to explain findings and recommendations.
UAE Regulatory & Data Privacy Adherence
This genetic testing service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. All processing is conducted at an ISO 9001:2015 certified facility (Cert: INT/EGQ/2509DA/3139).
For medical emergencies, please call 999 or visit your nearest Emergency Department. This page provides educational information and does not replace professional medical advice.
Clinical & Logistical Metadata
| Test Name | ACADM Gene (Medium-Chain Acyl-CoA Dehydrogenase Deficiency) Genetic Test – NGS |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA tube) |
| Methodology Used | Next Generation Sequencing (NGS) – Whole Gene Sequencing |
| ICD-10-CM Code | E71.31 (Medium-chain acyl-CoA dehydrogenase deficiency) |
| LOINC Code | 82232-2 (ACADM gene mutation analysis) |
| DHA Facility License & Address | License #1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians