Test Price
2,800 AED✅ Home Collection Available
ACADL Gene LCAD Deficiency NGS Genetic Test | DNA Labs UAE
Executive Summary & Core Metrics
This advanced next-generation sequencing (NGS) assay analyzes the ACADL gene to detect pathogenic variants associated with Long-Chain Acyl-CoA Dehydrogenase (LCAD) deficiency. Performed at our ISO 9001:2015 certified laboratory in Dubai Healthcare City, the test delivers >99.5% analytical sensitivity for single nucleotide variants (SNVs), indels, and copy number variations (CNVs). Our integrated service includes mandatory pre-test genetic counseling, VIP mobile phlebotomy with temperature-controlled cold-chain transport (daily 8 AM to 11 PM), and comprehensive post-test telemedicine consultation with a DHA-licensed Consultant Medical Geneticist.
Test Overview & Methodology
The ACADL Gene LCAD Deficiency NGS Test is a next-generation sequencing assay that screens the entire coding region of the ACADL gene for pathogenic variants linked to Long-Chain Acyl-CoA Dehydrogenase (LCAD) deficiency – a rare autosomal recessive inborn error of mitochondrial fatty acid oxidation. This advanced test is essential for confirming clinical suspicion, carrier testing, family screening, and guiding dietary management under UAE healthcare regulations.
| Feature | Our NGS Test (UAE) | Standard Single-Gene Sequencing |
|---|---|---|
| Methodology | NGS with full exon coverage & copy number variant (CNV) analysis | Sanger sequencing (may miss large deletions/duplications) |
| Turnaround Time | 3–4 weeks (expedited reporting available) | 4–6 weeks |
| Detection Rate | >99.5% analytical sensitivity for SNVs, indels, and CNVs in ACADL | ~95% (misses copy number changes) |
| Pre-Test Support | Mandatory genetic counselling & pedigree charting (included) | Often not provided |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Genetics, I underscore that the identification of a pathogenic or likely pathogenic variant in the ACADL gene is not a standalone diagnosis. Clinical correlation with plasma acylcarnitine profiles, urine organic acids, and fasting tolerance tests is mandatory. Do not interpret these results in isolation. A negative result does not entirely rule out a fatty acid oxidation disorder, as non-coding or large structural rearrangements may occasionally evade detection by standard NGS platforms. Patients should undergo detailed dietary and metabolic specialist evaluation prior to initiating any therapeutic intervention.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠ Medical Advisory
Do not discontinue prescribed medications, metabolic formulas, or dietary modifications based solely on a preliminary genetic report. All treatment adjustments must be supervised by a metabolic specialist.
Exclusion Criteria & Emergency Red Flags
- Testing is contraindicated for individuals currently experiencing acute metabolic decompensation, severe hypoglycemia, or hepatic dysfunction.
- Informed consent must be obtained from a legal guardian for minors.
- Emergency Red Flags: If you or a family member exhibit unexplained seizures, lethargy, vomiting, or respiratory distress during illness, seek emergency medical care immediately. Do not delay treatment to wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What does a positive ACADL gene variant mean for my health?
A positive result indicates the presence of one or two pathogenic mutations in the ACADL gene. If two mutations are found (homozygous or compound heterozygous), it confirms a diagnosis of LCAD deficiency, a disorder impairing the breakdown of long-chain fatty acids. This condition is manageable through dietary intervention—such as medium-chain triglyceride supplementation and avoidance of fasting—alongside cardiorespiratory monitoring. Carrier status (one mutation) poses minimal health risk but has implications for family planning and should prompt cascade screening of relatives.
2. How is the sample collected, and is a home service available in the UAE?
A standard peripheral blood sample (3–5 mL in EDTA) is required. DNA Labs UAE offers a VIP mobile phlebotomy service across Dubai, Abu Dhabi, and the Northern Emirates, operating daily from 8 AM to 11 PM. Samples are transported under strict temperature-controlled cold-chain conditions to our facility in Dubai Healthcare City to ensure genomic integrity.
3. Will my insurance cover the cost of the ACADL LCAD deficiency genetic test?
Coverage depends on your specific UAE health insurance policy and the medical necessity criteria established by the DHA or HAAD. Many comprehensive plans cover genetic testing when ordered by a specialist. We recommend contacting our billing team via WhatsApp at +971 54 548 8731 with your policy details for a complimentary verification of benefits and pre-authorization assistance.
UAE Regulatory & Data Privacy Adherence
- All personal genetic data is processed and stored in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Our laboratory operations adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient consent and medical liability protocols are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory supervised by Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403).
- Corporate Lab Branding: DNA Labs UAE. DHA Facility License Number: 1143.
Clinical & Logistical Metadata
| Parameter | Specification |
|---|---|
| Test Name | ACADL Gene LCAD Deficiency NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Dried Blood Spot (DBS) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Exon Coverage with CNV Analysis |
| ICD-10-CM Code | E71.39 |
| LOINC Code | 21661-2 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – License No. 1143 |
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