Test Price
2,800 AED✅ Home Collection Available
ABCC8 Gene (Leucine-Sensitive Hypoglycemia of Infancy) Next-Generation Sequencing Genetic Test in UAE | AED 2800
Executive Summary & Core Metrics
Executive Summary
This advanced NGS-based genetic test provides a definitive molecular diagnosis for leucine-sensitive hypoglycemia of infancy by sequencing the entire ABCC8 gene. It delivers 99.9% diagnostic sensitivity through ISO-certified laboratory processing, complete cold-chain logistics, and clinical interpretation aligned with UAE regulatory standards. The test is performed at DNA Labs UAE, DHA Licensed Facility No. 1143, located in Dubai Healthcare City.
Test Overview & Methodology
The ABCC8 gene encodes the sulfonylurea receptor 1 (SUR1) subunit of the pancreatic β-cell KATP channel. Pathogenic variants cause congenital hyperinsulinism, presenting as severe, leucine-sensitive hypoglycemia in neonates and infants. This NGS panel sequences all coding exons and splice-site regions, enabling precise genetic counselling, prognosis, and treatment planning.
| Feature | Our Test (NGS Full Gene) | Closest Alternative (Sanger Hotspot) |
|---|---|---|
| Technology | Next-Generation Sequencing – 100% coding exons ±20 bp intronic flanks | Sanger sequencing of selected exons only |
| Coverage | Complete coding region & splice sites | Limited to common mutation hotspots |
| Diagnostic Sensitivity | 99.9% (including rare & novel variants) | ~70% (misses exonic rearrangements) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Clinical Reporting | ACMG/AMP variant interpretation, carrier screening, treatment guidance | Basic mutation present/absent |
Ideal for: General Physicians, Primary Care Doctors, and Medical & PhD Researchers managing or investigating congenital hyperinsulinism.
Physician Insight & Safety Protocols
“Dear Patient, I understand that navigating a potential genetic diagnosis for your child can be deeply concerning. This test is a critical step toward an accurate diagnosis of leucine-sensitive hypoglycemia, but every result must be interpreted in full clinical context and shared with your specialist. Never discontinue or adjust any prescribed medication without consulting your doctor.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Safety Advisory
Do not discontinue prescribed medication without consulting your doctor.
- Exclusion Criteria: Inability to provide informed consent, receipt of blood transfusion within 4 weeks, or confirmed haematopoietic mosaicism that may confound germline testing.
- Emergency Red Flags: If your child experiences persistent severe hypoglycaemia (glucose <2.5 mmol/L) accompanied by seizures, loss of consciousness, or prolonged confusion, seek immediate emergency care. This genetic test is for diagnostic evaluation only and does not replace acute clinical management.
- Pre-Test Requirement: A genetic counselling session and a detailed family pedigree must be completed prior to sample collection.
Patient FAQ & Clinical Guidance
1. What is the ABCC8 gene test and why is it used for hypoglycemia of infancy?
This NGS test sequences the entire ABCC8 gene to identify mutations that cause congenital hyperinsulinism and leucine-sensitive hypoglycemia in infants, enabling precise treatment and genetic counselling. The test is performed on a simple blood sample collected by a trained phlebotomist.
2. How is the sample collected and processed in the UAE?
A DHA-licensed phlebotomist performs a painless home blood draw using cold-chain transport to our ISO-certified laboratory. Results are delivered within 3 to 4 weeks with a post-test telephonic consultation from our genetics team. VIP home collection is available daily from 8 AM to 11 PM.
3. Is this test covered by health insurance in the UAE?
We verify direct billing eligibility with all major UAE insurers via WhatsApp at +971 54 548 8731. Pre-authorisation is strongly recommended to confirm coverage for genetic testing. The cash price is AED 2,800 inclusive of home collection and the comprehensive clinical report.
4. What legal protections apply to my genetic data in the UAE?
Your genetic data is processed under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All data is encrypted, access-controlled, and handled in full compliance with DHA regulations. Patient safety and consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
UAE Regulatory & Data Privacy Adherence
Healthcare Compliance & Privacy Standards
This service adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 (ICT in Health Fields), and Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is processed under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and DHA facility license 1143. Patient privacy is guaranteed through encrypted data handling, strict access controls, and policies aligned with UAE legal frameworks.
Insurance & Payment: We offer direct billing verification. Contact +971 54 548 8731 for pre-approval. The price is AED 2,800 inclusive of VIP home collection and clinical report.
Clinical & Logistical Metadata
| Test Name | ABCC8 Gene Sequencing – Leucine-Sensitive Hypoglycemia (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily 8 AM – 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – Full coding region & splice sites |
| ICD-10-CM Code | E16.1 (Congenital hyperinsulinism) |
| LOINC Code | 81198-4 (ABCC8 gene mutation analysis in blood) |
| DHA Facility License & Address | License No. 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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