Test Price
2,800 AEDโ Home Collection Available
ABCA1 Gene NGS Analysis for Coronary Artery Disease & Familial Hypercholesterolemia Risk Assessment in UAE
Executive Summary & Core Diagnostic Metrics
Core Metrics
This advanced NGS-based analysis interrogates the ABCA1 gene for pathogenic variants associated with premature coronary artery disease (CAD) and familial hypercholesterolemia (FH). It provides a definitive genomic cornerstone for hereditary cardiovascular risk stratification in the UAE population.
- Accuracy Guarantee: >99.9% Diagnostic Sensitivity & Specificity via ISO 15189 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM โ 11 PM).
- Clinical Guidance: Comprehensive post-test telephonic genetic counseling session included.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Advanced Genomic Methodology
The ABCA1 gene encodes a crucial cholesterol efflux regulatory protein (ATP-binding cassette transporter A1). Pathogenic mutations in this gene disrupt reverse cholesterol transport, leading to Tangier disease and severe familial HDL deficiency, significantly amplifying atherosclerotic cardiovascular disease risk. This Next-Generation Sequencing (NGS) assay provides comprehensive exon coverage and deep intronic variant detection for precise clinical risk classification.
| Feature | DNA Labs UAE ABCA1 NGS Panel | Alternative Genomic Assays |
|---|---|---|
| Precision | >99.9% Analytical Sensitivity & Specificity | Variable; may miss rare/novel structural variants |
| Method | Full Gene NGS (Next-Generation Sequencing) | Limited Sanger Sequencing or targeted SNP array |
| Turnaround | 3โ4 Weeks with Integrated Genetic Counseling | May require separate counseling, slower overall workflow |
Clinical Expert Insight & Patient Safety Protocols
โInterpreting ABCA1 variants requires comprehensive lipid profiling and meticulous family history mapping. This NGS-based analysis provides a definitive genetic cornerstone for managing hereditary dyslipidemias within the UAE population. It is essential that results are contextualized within a complete clinical picture by a qualified genetic specialist.โ
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Patient Safety Advisory
Do not discontinue, adjust, or initiate any prescribed lipid-lowering or cardiovascular medication based solely on genetic test results. Genetic predisposition is one component of a multifactorial risk profile. All therapeutic decisions must be made in direct consultation with your treating physician or cardiologist.
Exclusion Criteria & Clinical Red Flags
- Not indicated for minors under 18 years without explicit parental consent and formal pre- and post-test genetic counseling (per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- This analysis is not a diagnostic tool for acute coronary syndromes (ACS), unstable angina, or acute myocardial infarction.
- Seek immediate emergency care if you experience chest pain, radiating jaw/arm pain, dyspnea, palpitations, or syncope โ do not delay treatment awaiting genetic results.
Patient Frequently Asked Questions & Clinical Guidance
1. What specific conditions does the ABCA1 gene test evaluate?
This NGS test detects pathogenic mutations in the ABCA1 gene, which are strongly linked to familial hypercholesterolemia (FH) and early-onset coronary artery disease (CAD). It specifically assesses hereditary risks related to impaired cholesterol efflux and HDL metabolism.
2. How is the blood sample collected for this genomic analysis?
A standard peripheral whole blood sample (5-10 mL) is collected via venipuncture. Our premium logistics network supports temperature-controlled cold-chain home collection or secure drop-off at our Dubai Healthcare City facility, ensuring complete genomic integrity.
3. When will I receive my genetic test results and how are they delivered?
Results are available digitally within 3 to 4 weeks. Delivery includes a secure, encrypted PDF report detailing detected variants and clinical significance, followed by a mandatory telephonic genetic counseling session to guide you through the findings and implications.
UAE Regulatory Compliance & Data Privacy Adherence
Your Data, Protected by Law
DNA Labs UAE operates under the strictest regulatory frameworks to safeguard your genomic and medical data:
- Data Privacy: Full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Security: Adherence to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical Governance: All sample collection and result disclosure protocols align with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | ABCA1 Gene NGS Analysis for CAD & Familial Hypercholesterolemia |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole Blood / Peripheral Blood |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | E78.0, I25.1 |
| LOINC Code | 92031-4 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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