Test Price
2,800 AED✅ Home Collection Available
AAGAB Gene Keratoderma, Palmoplantar, Punctate Type 1A Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين AAGAB لتقرن الجلد الراحي الأخمصي المنقط من النوع 1A باستخدام التسلسل الجيني الفائق (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
📋 Executive Summary
Guaranteed Precision: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited, NGS‑based analysis of the AAGAB gene – validated by DHA‑licensed specialists.
ملخص تنفيذي: دقة تشخيصية مضمونة بنسبة 99.9% من خلال تحليل الجين AAGAB بتقنية التسلسل الفائق (NGS) المعتمدة من هيئة الصحة بدبي.
Premium Logistics: Hospital‑Grade Home Collection (8 AM‑11 PM) with ISO‑Certified Cold‑Chain Transport for whole blood, extracted DNA, or FTA card samples.
Clinical Guidance: Complimentary post‑test tele‑counselling with a Consultant Dermatologist or Clinical Geneticist to interpret your results within the context of family history and clinical phenotype.
Insurance Support: Direct Billing Verification via WhatsApp: +971 54 548 8731 — we handle pre‑approvals with all major UAE insurers.
Test Overview
This advanced DNA test uses Next‑Generation Sequencing (NGS) to fully analyse the AAGAB gene for pathogenic variants causing palmoplantar punctate keratoderma type 1A – a rare hereditary skin disorder manifesting as painful punctate papules on palms and soles. The same test is invaluable for differential diagnosis, pre‑symptomatic screening and family carrier detection.
يستخدم هذا الاختبار المتطور تقنية التسلسل الفائق (NGS) لتحليل شامل لجين AAGAB للكشف عن الطفرات المسببة لتقرن الجلد الراحي الأخمصي المنقط من النوع 1A، وهو مرض جلدي وراثي نادر يتميز بحطاطات دقيقة مؤلمة على راحة اليدين وأخمص القدمين.
| Feature | Our Test (AAGAB NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Analytical Precision | 99.9% coverage of coding regions | ~95% (exonic only, may miss deep intronic variants) |
| Turnaround Time | 3–4 weeks | 5–8 weeks (single exon at a time) |
| Methodology | Illumina® NGS platform, bioinformatics‑validated | Capillary Sanger sequencing |
| Regulatory Status | DHA‑approved, ISO 9001:2015 (INT/EGQ/2509DA/3139) | Often non‑accredited local labs |
Physician Insight & Safety Protocol
Clinical Insight from Dr. Prabhakar Reddy (DHA 61713011), Consultant Dermatologist: “A positive AAGAB mutation confirms the diagnosis of punctate palmoplantar keratoderma but does not always predict severity. I always correlate genetic findings with a thorough skin examination and family pedigree to tailor monitoring and treatment. This test empowers you with clarity, yet clinical judgement remains paramount.”
⚠ Medication Safety Notice
Do not discontinue any prescribed medication or modify your treatment plan without consulting your treating physician. Genetic test results provide risk information, not therapeutic directives.
🚨 Exclusion Criteria & ER Red Flags
- Informed consent mandatory – test not performed without genetic counselling.
- Not suitable for emergency diagnosis. If you have acute skin breakdown, ulceration, or systemic infection, visit an ER immediately.
- Individuals with severe psychological distress regarding hereditary conditions should first consult a clinical psychologist or genetic counsellor.
- If results show a novel variant of uncertain significance, further family studies may be required – do not self‑interpret.
Patient FAQ & Clinical Guidance
1. How accurate is the AAGAB gene NGS test for diagnosing punctate palmoplantar keratoderma type 1A?
This achieves 99.9% diagnostic sensitivity by sequencing every coding exon of the AAGAB gene with deep coverage, ensuring even low‑level mosaic variants are detected.
يتمتع هذا الاختبار بحساسية تشخيصية تصل إلى 99.9% من خلال تسلسل جميع إكسونات جين AAGAB المشفرة بتغطية عميقة، مما يضمن اكتشاف حتى الطفرات الفسيفسائية منخفضة المستوى.
2. What sample is required and how is the home collection arranged?
We accept a single blood drop on an FTA card, extracted DNA, or 3–5 mL whole blood in an EDTA tube; our phlebotomist visits your home
نقبل عينة دم واحدة على بطاقة FTA أو حمض نووي مستخلص أو 3-5 مل من الدم الكامل في أنبوب EDTA؛ يزورك أخصائي سحب الدم في منزلك.
3. Are results confidential and compliant with UAE privacy laws?
Yes, your genetic data is protected under Federal Decree‑Law No. 41 of 2024 and UAE PDPL, stored encrypted with access only to DHA‑licensed clinicians.
نعم، تحمى بياناتك الجينية بموجب المرسوم بقانون اتحادي رقم 41 لسنة 2024 وقانون حماية البيانات الشخصية في الإمارات، وتُخزّن مشفرة ولا يصل إليها إلا الأطباء المرخصون من هيئة الصحة بدبي.
2026 ICD‑10‑CM Codes: Q82.8 (Other specified congenital malformations of skin), Z15.09 (Genetic susceptibility to other disease), L98.8 (Other specified disorders of the skin and subcutaneous tissue).
LOINC Code: 81247-7 (Genetic variation analysis panel).
UAE Legal Compliance: This service adheres to Federal Decree‑Law No. 41 of 2024 (Art. 87), CDS Law 2026 protections for minors, and UAE PDPL data privacy standards. ISO 9001:2015 Certification INT/EGQ/2509DA/3139 maintained. DHA facility license 9834453.
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians