Test Price
2,800 AED✅ Home Collection Available
AAGAB Gene Keratoderma, Palmoplantar, Punctate Type 1A Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
Guaranteed Precision
99.9% diagnostic sensitivity via ISO 9001:2015 accredited, NGS‑based analysis of the AAGAB gene – validated by DHA‑licensed specialists.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM‑11 PM) for whole blood, extracted DNA, or FTA card samples.
Clinical Guidance: Complimentary post‑test tele‑counselling with a Consultant Medical Geneticist to interpret your results within the context of family history and clinical phenotype.
Insurance Support: Direct Billing Verification via WhatsApp: +971 54 548 8731 — we handle pre‑approvals with all major UAE insurers.
Test Overview & Methodology
This advanced DNA test uses Next‑Generation Sequencing (NGS) to fully analyse the AAGAB gene for pathogenic variants causing palmoplantar punctate keratoderma type 1A – a rare hereditary skin disorder manifesting as painful punctate papules on palms and soles. The same test is invaluable for differential diagnosis, pre‑symptomatic screening and family carrier detection.
| Feature | Our Test (AAGAB NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Analytical Precision | 99.9% coverage of coding regions | ~95% (exonic only, may miss deep intronic variants) |
| Turnaround Time | 3–4 weeks | 5–8 weeks (single exon at a time) |
| Methodology | Illumina® NGS platform, bioinformatics‑validated | Capillary Sanger sequencing |
| Regulatory Status | DHA‑approved, ISO 9001:2015 (INT/EGQ/2509DA/3139) | Often non‑accredited local labs |
Physician Insight & Safety Protocols
Clinical Insight from Lina Osama Zaki Quteineh (DHA 9294403), Consultant Medical Genetics: “A positive AAGAB mutation confirms the diagnosis of punctate palmoplantar keratoderma but does not always predict severity. I always correlate genetic findings with a thorough skin examination and family pedigree to tailor monitoring and treatment. This test empowers you with clarity, yet clinical judgement remains paramount.”
Advisory: Genetic Counseling & Consent
Informed consent is mandatory before testing. A certified genetic counsellor will explain the implications of possible results, including variants of uncertain significance. This test is not a substitute for medical advice – always discuss findings with your healthcare provider.
Exclusion Criteria & ER Red Flags
- Not suitable for emergency diagnosis. Acute skin breakdown, ulceration, or systemic infection requires immediate ER visit.
- Individuals with severe psychological distress regarding hereditary conditions should first consult a clinical psychologist or genetic counsellor.
- If results show a novel variant of uncertain significance, further family segregation studies may be required – do not self‑interpret.
- Testing is not performed without prior genetic counselling and signed consent.
Patient FAQ & Clinical Guidance
1. How accurate is the AAGAB gene NGS test for diagnosing punctate palmoplantar keratoderma type 1A?
This achieves 99.9% diagnostic sensitivity by sequencing every coding exon of the AAGAB gene with deep coverage, ensuring even low‑level mosaic variants are detected.
2. What sample is required and how is the home collection arranged?
We accept a single blood drop on an FTA card, extracted DNA, or 3–5 mL whole blood in an EDTA tube. Our VIP Mobile Phlebotomy service visits your home daily from 8 AM to 11 PM, using temperature‑controlled cold‑chain transport to preserve sample integrity.
3. Are results confidential and compliant with UAE privacy laws?
Yes, your genetic data is protected under Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All data is encrypted and accessible only to DHA‑licensed clinicians.
UAE Regulatory & Data Privacy Adherence
Data Protection: This service complies fully with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 on the Use of Information and Communication Technology in Health Fields. Your genetic data is processed securely and never shared without explicit consent.
Medical Liability: Patient safety and consent procedures adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability.
Accreditations: ISO 9001:2015 (INT/EGQ/2509DA/3139) certified laboratory. DHA Facility License: 1143.
Clinical & Logistical Metadata
| Test Name | AAGAB Gene Sequencing (NGS) for Palmoplantar Punctate Keratoderma Type 1A |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next‑Generation Sequencing (Illumina® NGS, whole gene coverage) |
| ICD-10-CM Code | Q82.8, Z15.09, L98.8 |
| LOINC Code | 81247-7 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians