Test Price
2,800 AEDโ Home Collection Available
AAAS Gene (Achalasia-Addisonianism-Alacrimia Syndrome) Next-Generation Sequencing (NGS) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counselling and result interpretation by DHA-licensed clinical experts.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Compliant with UAE Personal Data Protection Law (PDPL) and Federal Law No. 2 of 2019 for health data protection.
Test Overview & Methodology
This NGS-based genetic test comprehensively analyses the AAAS gene to diagnose Triple A (Allgrove) syndrome, a rare autosomal recessive disorder characterized by achalasia, addisonianism (adrenal insufficiency), and alacrimia. The test employs next-generation sequencing to detect single nucleotide variants, insertions/deletions, and splice-site mutations with high sensitivity and specificity.
| Feature | Our Test (NGS AAAS Panel) | Closest Alternative (Single-Gene Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% coverage of all coding exons, splice sites, and deep intronic variants via NGS with orthogonal confirmation. | Limited to targeted exons; may miss deep intronic or large deletions. |
| Methodology | Next-Generation Sequencing (NGS) with bioinformatic pipeline aligned to DHA/MOHAP standards. | Sanger sequencing of limited genomic regions. |
| Turnaround Time | 3 to 4 weeks inclusive of rigorous quality control and clinical interpretation. | Often 6โ8 weeks due to iterative primer design. |
Physician Insight & Safety Protocols
โThis genetic test provides critical information for confirming Triple A syndrome and guiding multidisciplinary care. As a Consultant Medical Genetics, I emphasize that results should be interpreted within the full clinical context, including family history and biochemical findings. Early molecular diagnosis enables life-saving adrenal surveillance and coordinated specialist follow-up. Remember that genetic testing complements, but does not replace, comprehensive clinical evaluation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory
Patients should continue all prescribed medications unless instructed by their physician. This test does not require any special preparation. Ensure you inform the phlebotomist of any history of bleeding disorders or anticoagulant use. For adrenal insufficiency patients, stress-dose steroids may be needed during blood draw; consult your endocrinologist.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent allogeneic bone marrow transplant or blood transfusion within the last 2 weeks may interfere with germline DNA analysis.
- Exclusion: Patients currently undergoing DNA-based therapy (e.g., gene editing trials) should consult their physician regarding feasibility.
- Emergency Red Flag: Signs of acute adrenal crisis (severe hypotension, abdominal pain, confusion, loss of consciousness) require immediate emergency medical attention, not laboratory testing.
Patient FAQ & Clinical Guidance
1. What is the AAAS gene test and why is it important?
A: The AAAS gene NGS test identifies disease-causing variants in the AAAS gene, confirming Triple A syndrome and enabling early intervention. This molecular confirmation allows clinicians to initiate adrenal surveillance, gastroenterology management, and ophthalmology follow-up.
2. How is the test performed and what does the price include?
A: A simple blood draw by our VIP mobile phlebotomist, transported under cold-chain, with full genetic counselling and post-test interpretation at 2800 AED. The price covers the genetic analysis, clinical report, and telephone consultation with a genetic counsellor.
3. Which medical specialists are involved in interpreting this test?
A: A multi-disciplinary team of Consultant Medical Genetics, Gastroenterologists, and Endocrinologists collaborates to deliver clinically actionable reports tailored to your symptoms. Our DHA-licensed experts ensure the result is interpreted in context of your medical history.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
This diagnostic service operates under DHA Facility License No. 1143 and complies with UAE federal laws including the Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All genetic data is handled with strict confidentiality and stored securely.
Clinical & Logistical Metadata
| Test Name | AAAS Gene (Achalasia-Addisonianism-Alacrimia Syndrome) Next-Generation Sequencing (NGS) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E27.4, K22.0, H04.2 |
| LOINC Code | 81261-3 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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