Test Price
2,800 AED✅ Home Collection Available
CYP3A5 Gene Susceptibility to Salt-Sensitive Essential Hypertension Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- ✓ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified NGS processing using Illumina platform.
- ✓ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- ✓ Clinical Guidance: Post-test telephonic consultation with a Consultant Medical Genetics for comprehensive result interpretation.
- ✓ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CYP3A5 gene influences salt sensitivity and essential hypertension risk. This genetic test identifies variant alleles (*1, *3, *6, *7) that affect drug metabolism and blood pressure regulation, enabling precise prevention and personalised therapy. Full-gene sequencing via Next Generation Sequencing (NGS) on the Illumina platform delivers comprehensive coverage of all clinically relevant polymorphisms in the CYP3A5 gene region.
| Feature | Our Test (Premium UAE) | Closest Alternative |
|---|---|---|
| Precision | NGS full-gene sequencing with 99.9% analytical sensitivity | Targeted genotyping (limited variants) |
| Methodology | Next Generation Sequencing (Illumina NGS platform) | PCR-RFLP or TaqMan single-site assay |
| Clinical Integration | ICD-10 coded report with cardiologist-backed interpretation and pharmacogenomic guidance | Basic genetic variant PDF without clinical guidance |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I remind patients that a CYP3A5 variant indicates predisposition, not destiny. Your salt-sensitive blood pressure response must be correlated with clinical findings, family history, and lifestyle. Never adjust hypertension medication based solely on this genetic result without consulting your treating cardiologist or primary care physician. Pre-test genetic counselling is mandatory to ensure informed decision-making and compliance with UAE federal healthcare regulations.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue, alter, or start any antihypertensive or diuretic medication without the explicit instruction of your licensed physician. CYP3A5 genotype affects metabolism of certain calcium channel blockers and may influence salt-sensitivity; abrupt changes can cause hypertensive crisis or electrolyte imbalance. All pharmacogenomic test results must be interpreted within the full clinical context by a licensed medical professional.
Exclusion Criteria & Clinical Red Flags
- Children under 18 – genetic susceptibility testing is prohibited without a court order under UAE federal regulations protecting minors.
- Current hypertensive emergency (SBP >180 mmHg or DBP >120 mmHg) with end-organ damage – seek immediate emergency care; genetic testing is not urgent.
- Recent blood transfusion (≤4 weeks) or allogeneic bone marrow transplant – donor DNA may confound results.
- Severe haemodynamic instability or active bleeding disorder contraindicating blood draw.
Patient FAQ & Clinical Guidance
1. How does CYP3A5 genotyping guide my hypertension treatment?
A CYP3A5 expresser status directly impacts your body's ability to metabolize certain calcium channel blockers such as nifedipine and amlodipine. This pharmacogenomic information allows your cardiologist to select the most effective antihypertensive agent with minimal side effects, potentially avoiding trial-and-error prescribing.
2. Why does the test require a genetic counselling session beforehand?
Pre-test genetic counselling ensures you understand the hereditary implications of salt-sensitive hypertension and helps construct a family pedigree chart, which is mandatory for accurate risk assessment and compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability. The counsellor will explain the scope, limitations, and possible outcomes of genetic testing.
3. Can I get tested if I am currently taking antihypertensive medication?
Yes, you can be tested while on medication. However, you must provide a complete list of current medications to the genetic counsellor and ordering physician. The genotype result may explain your current response to therapy and guide potential adjustments, but no medication changes should be made without explicit physician approval.
4. What is the turnaround time for results?
The standard turnaround time for CYP3A5 NGS testing is 10 to 14 business days from sample receipt at our laboratory. Expedited processing may be available upon request. Results are delivered electronically through our secure patient portal with a comprehensive interpretive report.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with UAE federal data protection and healthcare information security regulations. All genetic data is processed and stored under the provisions of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and clinical safety are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Our DHA-licensed facility maintains strict confidentiality protocols for all genomic data, ensuring that your genetic information is never shared with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | CYP3A5 Gene Susceptibility to Salt-Sensitive Essential Hypertension Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 10 to 14 Business Days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next Generation Sequencing (NGS) – Illumina Platform |
| ICD-10-CM Code | I10, Z13.6 |
| LOINC Code | 94483-8 |
| DHA Facility License & Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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