Test Price
2,800 AED✅ Home Collection Available
CNKSR2 Gene Nonsyndromic Intellectual Disability (CNKSR2-Related) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing.
Premium Logistics: Hospital-grade home collection with ISO-certified cold-chain transport (VIP mobile phlebotomy).
Clinical Guidance: Post-test telephonic clinical correlation and interpretation support.
Insurance Verification: Direct billing confirmation via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The CNKSR2 NGS test sequences the entire coding region of the CNKSR2 gene to detect pathogenic variants linked to X-linked nonsyndromic intellectual disability. This test delivers a definitive molecular diagnosis that guides neurological and genetic counselling.
| Feature | Our Test (CNKSR2 NGS) | Closest Alternative (Single-Gene Sanger) |
|---|---|---|
| Precision | 99.9% sensitivity for SNVs, indels, and copy number variants | Limited to exon-by-exon sequencing; may miss deep intronic variants |
| Methodology | Next-Generation Sequencing (Illumina platform, paired-end 150 bp) | Sanger sequencing; single amplicon analysis |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks (often with reflex to NGS) |
Physician Insight & Safety Protocols
From the desk of Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA License: 9294403): "A pathogenic CNKSR2 variant confirms the genetic aetiology of intellectual disability and empowers families with accurate recurrence risk assessment. A negative result does not exclude other genetic causes; clinical correlation with detailed neurodevelopmental evaluation remains essential."
Advisory Notice
Medication Warning
Do not discontinue any prescribed neurological, antiepileptic, or psychotropic medication without direct consultation with your treating physician. This genetic test is diagnostic and does not replace ongoing medical management.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals with acute febrile illness or active infection (postpone blood draw until recovery).
- Exclusion: Neonatal heel-prick samples without DHA-approved paediatric collection kit (risk of insufficient DNA yield).
- Emergency red flag: If the patient experiences new-onset seizures, loss of consciousness, or severe behavioural regression before or after sample collection, contact emergency services immediately; do not rely on test results for acute management.
Patient FAQ & Clinical Guidance
1. What does the CNKSR2 NGS test detect?
This test identifies single-nucleotide variants, small deletions/insertions, and copy number changes in the CNKSR2 gene, confirming X-linked nonsyndromic intellectual disability with greater than 99.9% accuracy. It covers the full coding exons and flanking splice sites using next-generation sequencing.
2. How should I prepare for sample collection?
A pre-genetic counselling session is mandatory to draw a three-generation pedigree and document clinical history; no fasting is required. The sample can be collected via venipuncture (whole blood in EDTA tube), one drop of blood on an FTA card, or extracted DNA. Avoid concomitant use of DNA-degrading substances such as heparin in the collection line.
3. When will I receive results and what do they mean?
Results are delivered within 3 to 4 weeks via a secure patient portal, with optional tele-counselling to interpret pathogenic, likely pathogenic, and variants of uncertain significance. A board-certified neurologist and genetic counsellor jointly review each report to align with the most recent ACMG/AMP guidelines.
UAE Regulatory & Data Privacy Adherence
Data Protection and Privacy Compliance
DNA Labs UAE operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes with explicit patient consent.
Clinical Safety and Patient Consent
All testing procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring patient safety, informed consent, and clinical accountability throughout the diagnostic pathway.
Clinical & Logistical Metadata
| Test Name | CNKSR2 Gene Nonsyndromic Intellectual Disability (CNKSR2-Related) Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), FTA Card, or Extracted DNA – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available (Daily 8 AM – 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina Platform, Paired-End 150 bp |
| ICD-10-CM Code | Z13.71 |
| LOINC Code | 81274-5 |
| DHA Facility License & Laboratory Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians