Test Price
2,800 AED✅ Home Collection Available
TMIE Gene Deafness, Autosomal Recessive Type 6 Genetic Test | 2,800 AED
Executive Summary & Core Metrics
- Diagnostic Sensitivity: 99.9% detection rate for TMIE gene variants via NGS with ISO-accredited bioinformatics pipeline.
- Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Pre-test genetic counselling session included.
- Post-Test Guidance: Telephonic clinical consultation with a consultant medical geneticist for result interpretation.
- Insurance: Direct coverage verification through WhatsApp at +971 54 548 8731 prior to collection.
Test Overview & Methodology
This Next-Generation Sequencing (NGS) test identifies pathogenic variants in the TMIE gene to diagnose autosomal recessive deafness type 6 (DFNB6), a common cause of prelingual sensorineural hearing loss. The test is intended for individuals with congenital or early-onset hearing impairment, their families, and for genetic counselling to inform family planning and early intervention strategies.
| Feature | Our NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity for TMIE variants; detects single nucleotide, small indels, and copy number variants | ~95% sensitivity; limited to known hotspot regions |
| Methodology | High‑throughput NGS with ISO‑accredited bioinformatics pipeline | Capillary Sanger sequencing; lower throughput |
| Turnaround Time | 3 – 4 weeks from receipt of sample | 6 – 8 weeks |
Physician Insight & Safety Protocols
“As a clinical geneticist, I understand that genetic hearing loss can be challenging for families; this test offers definitive molecular diagnosis to guide audiological rehabilitation and informed reproductive choices. However, results must always be integrated with comprehensive audiometry and pedigree analysis to ensure personalized care. Knowledge empowers, but clinical correlation remains the foundation of every health decision.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Important Advisory
This genetic test provides diagnostic information only. Do not alter any treatments or medications based on results without consulting your physician. All clinical decisions require integration with audiological and medical assessment.
Safety Exclusion Criteria & Emergency Red Flags
- Patients with active bleeding disorders or severe anaemia should notify the phlebotomist; alternative sample collection (buccal swab) may be arranged.
- Minors require a legal guardian’s informed consent as per UAE health data protection regulations.
- If you experience sudden hearing deterioration, severe vertigo, or acute ear pain with fever, seek emergency medical attention immediately — these symptoms are not indicative of the genetic condition being tested and require urgent evaluation.
Patient FAQ & Clinical Guidance
1. What is the TMIE Gene Deafness Autosomal Recessive Type 6 NGS Test?
This test analyzes the TMIE gene using Next-Generation Sequencing to detect pathogenic variants associated with DFNB6. It covers both coding exons and flanking intronic regions for maximum diagnostic yield. It is recommended for individuals with congenital or early-onset sensorineural hearing loss, and for families with a history of hereditary hearing loss.
2. Why do I need genetic counselling before this test?
Genetic counselling ensures you understand autosomal recessive inheritance patterns, family implications, and the psychological impact of identifying a genetic cause of deafness. Our certified genetic counsellors construct a detailed family pedigree, explain recurrence risks (25% for future siblings), and discuss reproductive options. This mandatory session fulfills Federal Decree-Law No. 4 of 2016 on Medical Liability requirements for informed consent.
3. How long do results take and what does the 2,800 AED cost include?
Results are delivered within three to four weeks at a total cost of 2,800 AED, including post-test telephonic clinical guidance with the ordering physician. The price covers home or clinic sample collection, DNA extraction, NGS sequencing, bioinformatic analysis, and a comprehensive clinical report. Direct insurance billing verification is available via WhatsApp at +971 54 548 8731 prior to the draw.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genetic testing and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139) and licensed by the Dubai Health Authority (DHA Facility License No. 1143). Physical address: Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | TMIE Gene (Deafness, Autosomal Recessive Type 6) NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA card sample |
| Methodology Used | Next-Generation Sequencing (NGS) with ISO-accredited bioinformatics analysis |
| ICD-10-CM Code | H90.3 (Sensorineural hearing loss, bilateral) |
| LOINC Code | 58122-8 (TMIE gene full sequencing) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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